Bikalutamid

General characteristics. Structure:

Active ingredient: 50 mg or 150 mg of a bikalutamid in 1 tablet.

The drug possessing anti-androgenic and antineoplastic action.

Pharmacological properties:

Pharmacodynamics. Contacting androgenovy receptors on a surface of cells of bodies-misheny, does them unavailable to androgens, increasing at the same time concentration of hormones in a blood plasma.

After intake it is quickly and completely soaked up (food does not influence completeness of absorption). In blood contacts proteins of plasma for 96%. Is exposed to stereospecific biotransformation in a liver. Inactive S-enantiomer, glyukuronidirutsya and is quickly brought out of an organism. Active R-enantiomer is also exposed to a glyukuronidation with formation of an inactive metabolite.

Pharmacokinetics. T1/2 makes about 7 days. It is excreted by kidneys and with bile in equal ratios.

Indications to use:

Prostate cancer.

Route of administration and doses:

Inside, irrespective of meal. Adult — 1 tab. (50 or 150 mg) once.

Features of use:

Use at pregnancy and feeding by a breast. Category of action on a fruit on FDA — X.

Side effects:

Stenocardia attack, hypertensia, heart failure, cough, pharyngitis, bronchitis, pneumonia, rhinitis, dispeptic phenomena, xerostomia, gastric bleedings, melena, alarm, depression, decrease libido, drowsiness, nervousness, myasthenia, mialgiya, arthritis, convulsive twitchings of muscles of extremities, contractures, stethalgia, diabetes mellitus, polyuria, dysuria, ischuria, hypostases, fever, perspiration, allergic reactions.

Interaction with other medicines:

Strengthens effects of indirect anticoagulants.

Contraindications:

Hypersensitivity, children's age, it is contraindicated to women.

Restrictions to use. Abnormal liver function.

Storage conditions:

To store at a temperature of 15-25 °C, in dry, protected from light and the place, unavailable to children. Period of validity 3 years. Not to use after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Tablets on 50 mg, 20 tablets in each blister, on one, two or three blisters together with the application instruction in cardboard packaging.

Tablets on 150 mg, 10 tablets in the blister, on one, two or three blisters together with the application instruction in cardboard packaging.