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medicalmeds.eu Medicines Antimicrobic means. Antigerpin

Antigerpin

Препарат Антигерпин. АО "Химфарм" Республика Казахстан


Producer: JSC Himfarm Republic of Kazakhstan

Code of automatic telephone exchange: D06BB03

Release form: Soft dosage forms. Ointment.

Indications to use: (Deprive) the surrounding herpes. Genital herpes. Herpes infection (Herpes).


General characteristics. Structure:

Active agent - an acyclovir (in terms of 100% substance) - 0,50 g.
Excipients: проксанол (half-oxameasures), propylene glycol, macrogoal (poly(ethylene oxide) 400), emulsifier No. 1.




Pharmacological properties:

Pharmacokinetics. At external use it is practically not soaked up in a system blood stream and has no systemic action. When putting ointment on an affected area of skin in it therapeutic concentration of drug which is maintained at the constant level not less than 5 hours is created.

Pharmacodynamics. Антигерпин® - antiviral drug, effective concerning viruses of the simple and surrounding herpes (depriving). Is an analog of a purine nucleoside of a dezoksiguanidin, the DNA component.

Similarity of structures of an acyclovir and dezoksiguanidin allows an acyclovir to interact with virus enzymes that leads to interruption of reproduction of a virus. After implementation of an acyclovir in the cell affected with herpes under the influence of the thymidinekinase allocated by a virus, the acyclovir turns into an acyclovir monophosphate which enzymes of a host cell turns into an acyclovir diphosphate, and then into an active form an acyclovir triphosphate which blocks replication of virus DNA. The acyclovir triphosphate practically does not influence DNA replication of a host cell (a cell of the person).

Антигерпин® at herpes prevents formation of new elements of rash, reduces probability of skin dissimination and visceral complications, accelerates formation of crusts, weakens pain in an acute phase of the surrounding herpes.


Indications to use:

- shingles, herpes of lips, the external genitals caused by a herpes simplex virus;

- primary and recurrent herpes infections at patients with an immunodeficiency.


Route of administration and doses:

Outwardly, ointment is applied a thin layer on affected areas of skin of 5 times a day by each 4 hours (as soon as possible after the beginning of an infection). For prevention of spread of an infection it is recommended to use rubber gloves or wadding sticks. Before putting ointment the struck surface needs to be washed up water with soap and to dry up carefully.

Prior to a procedure of treatment and after it it is necessary to wash up carefully hands to prevent additional infection of affected areas of skin (for example, bacteria) or transfer of a virus on healthy sites of skin.

Treatment should be begun at emergence of the first symptoms of a herpes infection.

Drug should be applied on areas not only with strong indications of defeat by herpes (bubbles, hypostasis, reddening), but also on the neighboring sites of skin.

It is regularly necessary to apply ointment; in cases of the admission of the next application it is not necessary to double a dose during the following use of drug.

Course of treatment of 5-10 days.


Features of use:

Ointment should not be applied on mucous membranes of an oral cavity, an eye, a nose and a vagina.

Efficiency of treatment by that will be higher, than earlier it is begun (at the first symptoms of an infection).

For implementation of medical effect of Antigerpina® the condition of immune system of an organism matters. Patients with reduced immunity (at HIV/AIDS or after transplantation of marrow) against the background of topical administration of Antigerpina® ointment should appoint system administration of drug, the same as in cases of a heavy recurrent current of a herpes infection.

Considering a possibility of transfer of a virus sexually, sexual contacts with a virus carrier or the patient it is necessary to avoid or apply individual means of protection.

Considering side effects of medicine, it is necessary to be careful at control of motor transport and moving mechanisms.


Side effects:

Are possible:

- skin rash which quickly passes after drug withdrawal;

- a peeling in the place of its drawing at prolonged use of ointment.

In some cases:

- local irritation of a mucous membrane, burning sensation and pain, itch.


Interaction with other medicines:

Strengthening of effect of Antigerpina® is noted at co-administration of immunostimulators.

Probenetsid slows down removal of Antigerpina® – the elimination half-life is extended.

Researches on interaction of Antigerpina® with other medicines were not conducted.


Contraindications:

- hypersensitivity to drug

- the infectious diseases with similar symptoms but caused by other activators;

- children's and teenage age up to 18 years in view of lack of data on safety and efficiency;

- pregnancy and period of a lactation.


Overdose:

It is not described.


Storage conditions:

To store in the dry, protected from light place, at a temperature not over 20 ºС.  To store in the place, unavailable to children!


Issue conditions:

Without recipe


Packaging:

On 10 g in tubas aluminum for medical ointments from bushona with an internal covering it is delicious.

Each tuba together with the approved instruction on a medical use in the state and Russian languages is placed in a pack from a cardboard for a retail container.

It is allowed information from the approved instruction on a medical use in the state and Russian languages to apply on a pack.



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