ФлюЗиОЗ

General characteristics. Structure:

Active вещества:Парацетамол - 0,5 gkislot ascorbic - 0,15 g; Auxiliary a veshchestva:kislota lemon, sugar, aspartame, fragrance with a fruit smell of natural.

Pharmacological properties:

The combined drug. Paracetamol - analgetic non-narcotic means, the mechanism of action is connected with braking of synthesis of prostaglandins and preferential influence on the center of thermal control in a hypothalamus. Ascorbic acid (vitamin C) plays an important role in regulation of oxidation-reduction processes, carbohydrate metabolism, fibrillation, an angenesis; participates in synthesis of glucocorticosteroids, collagen and procollagen; normalizes permeability of capillaries. Increases body resistance that is connected with stimulation of immune system.

Indications to use:

For decrease in the increased body temperature at infectious - inflammatory diseases (including "catarrhal").

Route of administration and doses:

Inside - on 1-2 bags 2-3 times a day. Drug should be dissolved completely in a glass of warm water and at once to drink the received solution. It is better to accept drug between meals. The interval between administrations of drug has to be not less than 4 hours. At patients with abnormal liver functions or kidneys and at elderly patients the interval between administrations of drug has to make not less than 8 hours. Reception duration without consultation with the doctor no more than 5 days at appointment as anesthetic and 3 days as an antipyretic.

Features of use:

At reception of Metoclopramidum, domperidon or Colestyraminum it is also necessary to consult with the doctor. Distortion  of indicators of laboratory researches  at  quantitative definition of concentration of uric acid and glucose in plasma is possible. In order to avoid toxic damage of a liver paracetamol should not be combined with reception of alcoholic beverages, and also to accept to the persons inclined to chronic consumption of alcohol. The risk of development of injuries of a liver increases at patients with an alcoholic hepatosis. At long use of drug control of a picture of peripheral blood and a functional condition of a liver is necessary.

Side effects:

Allergic reactions (skin rash, itch, small tortoiseshell, Quincke's edema), nausea, pain in epigastric area; anemia, thrombocytopenia; dryness in a mouth, accommodation paresis, an ischuria, drowsiness.

At prolonged use in high doses - a hepatotoxic action, hemolitic anemia, aplastic anemia, a methemoglobinemia, a pancytopenia; erosive cankers of digestive tract, bleeding in digestive tract; nephrotoxicity (papillary necrosis); formation of oxalic stones in kidneys.

Interaction with other medicines:

Ethanol strengthens sedative effect of antihistaminic drugs. Inductors of a microsomal oxidation in a liver (Phenytoinum, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase products of hydroxylated active metabolites that causes a possibility of development of heavy intoxications at small overdoses. Ethanol promotes development of acute pancreatitis. Inhibitors of a microsomal oxidation (including Cimetidinum) reduce risk of a hepatotoxic action. At reduction in the rate of gastric emptying (пропантелин) effect of drug is slowed down, at acceleration (Metoclopramidum) begins to work quicker. Increases toxicity of chloramphenicol. Paracetamol reduces efficiency of uricosuric drugs.

Contraindications:

• Hypersensitivity to paracetamol, ascorbic acid or any other component of drug
• Gastrointestinal bleeding
• Renal failure
• Portal hypertensia
• Alcoholism
• Deficit glyukozo-6-fosfatdegidrogenazy
• Children's age (up to 15 years).
• Pregnancy and period of a lactation

With care - a liver failure, digestive tract erosive cankers (in an aggravation phase), closed-angle glaucoma, a prostate hyperplasia, inborn hyperbilirubinemias (Gilbert's syndromes, the Cudgel Johnson and the Rotor), a viral hepatitis, alcoholic hepatitis, advanced age.

Overdose:

Symptoms: pallor of integuments, loss of appetite, nausea, vomiting; гепатонекроз (expressiveness of a necrosis owing to intoxication directly depends on extent of overdose). Toxic action at adults perhaps after reception over 10-15 g of paracetamol: increase in activity of "hepatic" transaminases, increase in a prothrombin time (in 12-48 h after reception); the developed clinical picture of damage of a liver is shown in 1-6 days. Seldom liver failure develops immediately and can be complicated by a renal failure (a tubular necrosis).

Treatment: in the first 6 h after overdose - a gastric lavage, introduction of donators of SH-rpynn and predecessors of synthesis of glutathione - methionine in 8-9 h after overdose and N-Acetylcysteinum - in 12 h. Need for holding additional therapeutic actions (further administration of methionine, in/in introduction of N-Acetylcysteinum) is defined by concentration of paracetamol in blood, and also time which passed after its reception.

Storage conditions:

In the dry place at a temperature not above +25 °C, unavailable to children.

Issue conditions:

Without recipe

Packaging:

On 5 g in the packages thermowelded from material of film combined. On 5,10 or 50 bags together with the application instruction in a pack cardboard.