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Инстенон®

Препарат Инстенон®. ЗАО "ФармФирма «Сотекс" Россия


Producer: CJSC Pharmfirma Soteks Russia

Code of automatic telephone exchange: C01EX

Release form: Liquid dosage forms. Solution for injections.

Indications to use: Dizziness. Disturbance of cerebral circulation.


General characteristics. Structure:

Active substances: Hexobendinum hydrochloride of 10 mg, этамиван 50 mg, этофиллин 100 mg,
Excipients: dinatrium эдетат 0,08 mg, propylene glycol of 416,00 mg, water for injections to 2,00 ml.

Description: transparent colourless liquid.




Pharmacological properties:

Инстенон® is the combined drug improving cerebral circulation and a metabolism. Etamivan due to activation of a reticular formation normalizes a functional condition of neural complexes of bark and subcrustal and trunk structures.

Hexobendinum increases utilization of glucose and oxygen due to activation of anaerobic glycolysis and pentozny cycles (are implemented only in the conditions of ischemia and a hypoxia when the cycle of aerobic oxidizing phosphorylation is broken).

Etofillin activates metabolism of a myocardium, increases the minute volume of heart that promotes increase in perfused pressure in vessels of a regional area of ischemia. At the same time system arterial pressure does not change.

Exciting action on a nervous system is shown also in stimulation of subcrustal educations, a mesencephalon, the trunk centers and kernels (respiratory, vasomotor, the centers of vegetative regulation, and also kernels craniocereberal, first of all - wandering).

Pharmacokinetics. Special researches for studying of pharmacokinetics of the drug Instenon® were not conducted, due to the lack of necessary pharmacokinetic methods.


Indications to use:

Chronic insufficiency of cerebral circulation, postinsultny conditions, dizzinesses of the central genesis.


Route of administration and doses:

Depending on weight of a state 1-2 times a day on 1 ampoule intramusculary, or intravenously slowly; or 1-2 times a day on one ampoule intramusculary, or intravenously slowly; or 1-2 times a day on one ampoule in the form of drop infusion together with 250 ml of 5% of solution of glucose.

In process of improvement of a state treatment can be continued by peroral forms of drug (a tablet, coated). In some cases at bystry introduction the arterial pressure therefore duration of introduction of one ampoule has to make not less than 3 min. can go down.


Features of use:

During treatment it is necessary to be careful at occupation potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.


Side effects:

Headache, hyperemia of the person, lowering of arterial pressure, tachycardia (passing).


Interaction with other medicines:

Strengthens action of antiagregant (acetylsalicylic acid, etc.).

Very high doses of caffeine can weaken action of Instenona® (it is necessary to avoid reception of large numbers of coffee and tea).


Contraindications:

The expressed excitement, spasms, epilepsy, the increased intracranial pressure, hemorrhage in a brain, hypersensitivity, pregnancy, the lactation period, children's age up to 18 years.

With care:
recently had stroke
stenosis of a carotid artery.


Overdose:

Symptoms: tachycardia, strengthening of expressiveness of side effects.

Treatment: gastric lavage, absorbent carbon, symptomatic therapy.


Storage conditions:

List B. At a temperature of 2-8 °C, in the place protected from light. To store in the place, unavailable to children. Period of validity: 3 years. Not to use after expiry date.


Issue conditions:

According to the recipe


Packaging:

Solution for intravenous and intramuscular administration. On 2,0 ml of drug in colourless glass ampoules of ORS the EP type I with a point of a break and three rings of gray, turquoise and gray color.

On 5 ampoules in a polystyrene strip packaging together with the application instruction in a cardboard pack.



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