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medicalmeds.eu Medicines Immunoexcitant. Цитовир®-3

Цитовир®-3

Препарат Цитовир®-3. ЗАО "Цитомед" МБ НПК Россия


Producer: CJSC Tsitomed of MB of NPK Russia

Code of automatic telephone exchange: L03AX

Release form: Liquid dosage forms. Powder for preparation of solution for intake.

Indications to use: Prevention of flu. Flu. SARS. Prevention of a SARS.


General characteristics. Structure:

Active ingredients: 0,15 mg alpha глутамил - tryptophane (тимоген sodium in terms of тимоген), 12 mg of ascorbic acid, 1,25 mg of Bendazolum of a hydrochloride [Dibazolum].

Excipients: in drug without fragrance: fructose; in drug with fragrance: fructose; fragrance identical natural "Orange" or "Cranberry", or "Strawberry".




Pharmacological properties:

Pharmacodynamics. Drug is means of the etiotropic and immunostimulating therapy, possesses the mediated antiviral action concerning influenza viruses And yes In and other viruses causing acute respiratory viral diseases.

Bendazolum induces production of endogenous interferon in an organism, possesses immunomodulatory action (normalizes an immune response of an organism). Enzymes which production is induced by interferon in cells of various bodies inhibit replication of viruses.

Alpha глутамил - tryptophane (тимоген) is synergist of immunomodulatory action of Bendazolum, normalizing the T-cellular link of immunity.

Ascorbic acid activates a humoral link of immunity, normalizes permeability of capillaries, reducing thereby an inflammation, and shows antioxidant properties, neutralizing the oxygen radicals accompanying inflammatory process increases resistance of an organism to an infection.

Pharmacokinetics. At intake drug is completely soaked up from digestive tract. Bioavailability of Bendazolum - about 80%, alpha глутамил - tryptophane - no more than 15%, ascorbic acid - to 70%. Ascorbic acid is absorbed in a GIT (preferential in a jejunum). Communication with proteins of plasma - 25%. Tmax after intake is 4 h. Easily gets into leukocytes, thrombocytes, and then into all fabrics, gets through a placenta. Gastrointestinal diseases (a peptic ulcer of a stomach and a 12-perstny gut, disturbance of motility of intestines, a helminthic invasion, a lambliasis), the use of fresh vegetable and fruit juice, alkaline drink reduce binding of ascorbic acid in intestines. Ascorbic acid preferential in a liver in dezoksiaskorbinovy, further in oxalacetic and diketogulonic acids is metabolized.

It is removed by kidneys, through intestines, with then, breast milk in not changed look and in the form of metabolites. Bendazolum biotransformation products in blood are two conjugates which are formed owing to methylation and a karboetoksilirovaniye of iminogroup of an imidazolny ring of Bendazolum: 1-methyl-2-benzylbenzimidazole and 1-karboetoksi-2-benzylbenzimidazole. Metabolites of Bendazolum are removed with urine. Alpha глутамил - tryptophane under the influence of peptidases is split on L-glutaminic acid and L-tryptophane which are used by an organism in protein synthesis.


Indications to use:

Prevention and complex therapy of flu and acute respiratory viral infections at children of one year.


Route of administration and doses:

Schemes of medical and preventive use are identical.

Inside in 30 min. prior to food.

For children aged from 1 up to 3 years - on 2 ml of solution 3 times a day;

For children aged from 3 up to 6 years - on 4 ml 3 times a day;

For children aged from 6 up to 10 years - on 8 ml 3 times a day;

For children 10 years - on 12 ml 3 times a day are aged more senior.

Use course - 4 days. The preventive course is repeated if necessary in 3-4 weeks.

Rules of preparation of solution: with powder to add 40 ml of water to a bottle (boiled, cooled to room temperature), it is good to shake up. Contents have to be dissolved completely. Solution volume after water addition - 50 ml.


Features of use:

Pregnancy and lactation. During pregnancy administration of drug is not shown in connection with insufficient clinical data. During breastfeeding use is possible if the estimated advantage for mother exceeds potential risk for the child.

At repeated courses periodic control of concentration of glucose in blood is recommended.


Side effects:

Short-term lowering of arterial pressure. Allergic reactions are possible: small tortoiseshell. In these cases use of drug is stopped and appoint a symptomatic treatment, antihistamines.


Interaction with other medicines:

Interactions alpha глутамил - tryptophane with medicines is not revealed.

Bendazolum - prevents the increase in OPSS caused by non-selective beta adrenoblockers. Strengthens hypotensive action of hypotensive and diuretic HP. Phentolamine strengthens hypotensive action of Bendazolum.

Ascorbic acid - increases concentration in blood of benzylpenicillin and tetracyclines. Improves absorption in intestines of the drugs Fe. Reduces efficiency of heparin and indirect anticoagulants.

Acetylsalicylic acid (ASK), oral contraceptives, fresh juice and alkaline drink reduce its absorption and assimilation. At simultaneous use with ASK allocation with urine of ascorbic acid increases and allocation of ASK decreases. ASK reduces absorption of ascorbic acid approximately by 30%. Ascorbic acid increases risk of development of a crystalluria at treatment by salicylates and streptocides of short action, slows down removal by kidneys of acids, increases removal of the HP having alkali reaction (including alkaloids), reduces concentration in blood of oral contraceptives. At simultaneous use reduces chronotropic action of an izoprenalin.

Reduces therapeutic action of antipsychotic HP (neuroleptics) - derivatives of a fenotiazin, a canalicular reabsorption of amphetamine and tricyclic antidepressants.

Barbiturates and Primidonum increase removal of ascorbic acid with urine.


Contraindications:

Hypersensitivity to drug components, a diabetes mellitus, pregnancy, children's age till 1 year.


Overdose:

Cases of overdose are noted.


Storage conditions:

To store in the dry place at a temperature not above 25 °C. To store in the place, unavailable to children. To store the prepared solution in the place protected from light at a temperature from 0 °C to 8 °C. A period of validity of the prepared solution of 10 days. A period of validity - 3 years. Not to use after the period of validity specified on packaging.


Issue conditions:

According to the recipe


Packaging:

Powder for приготов. solution for intake (for children) 20 g. Packaging: on 20 g in a bottle of dark glass or a polymeric bottle. The bottle is corked a plastic cover with control of the first opening or a plastic cover with control of the first opening and protection against children. On one bottle place in a pack from a cardboard. The application instruction is put in a pack or in the form of the put leaf placed under the opening part of the label. Put the portioning device in a pack (a measured glass or a spoon dosing, or a pipette dosing). It is allowed to put in a pack two portioning devices (a measured glass and a spoon dosing or a measured glass and a pipette dosing).



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