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medicalmeds.eu Medicines Antibiotic of group of tetracyclines. Minoleksin

Minoleksin

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General characteristics. Structure:

Active agent: minocycline hydrochloride of 50 mg; 100 mg.




Pharmacological properties:

Antibiotic of group of tetracyclines. Has bacteriostatic action due to suppression of synthesis of protein by reversible linkng with a ribosome subunit 30S of sensitive microorganisms.
It is active concerning gram-positive bacteria: Staphyloccocus aureus, Streptococcus spp., Nocardia spp., Listeria spp., Bacillus anthracis; gram-negative bacteria: Neisseria meningitidis, Bartonella bacilliformis, Vibrio cholerae, Esherichia coli, Klebsiella spp., Shigella spp., Acinetobacter spp., Haemophilus spp.; anaerobic bacteria: Clostridium spp., Bacteroides spp.
Minocycline is active also concerning Mycobacterium spp. (including Mycobacterium leprae), Chlamydia spp., Ureaplasma urealyticum, Treponema pallidum.


Indications to use:

Acne rash, nocardiosis, leprosy (as a part of a combination therapy); the infectious and inflammatory diseases caused by activators, sensitive to minocycline (including pneumonia, bronchitis, a pleura empyema, quinsy, cholecystitis, pyelonephritis, intestinal infections, an endocarditis, an endometritis, prostatitis, syphilis, gonorrhea, a brucellosis, rickettsioses, purulent infections of soft tissues, osteomyelitis, trachoma).


Route of administration and doses:

At intake the daily dose for adults makes 100-200 mg.
For children 8 years a dose are more senior makes 4 mg/kg, then 2 mg/kg each 12 h.


Features of use:

At reception with milk and dairy products minocycline absorption is broken.

Minocycline causes discoloration of teeth, a hypoplasia of enamel and a growth disorder of bones of a skeleton of a fruit and the child therefore minocycline is not applied at children up to 8 years.


Side effects:

Perhaps: vestibular frustration (dizziness, instability), xanthopathy and mucous membranes, hepatotoxic action, nausea, vomiting, candidiasis.


Interaction with other medicines:

It is not described.


Contraindications:

Abnormal liver function, children's age up to 8 years, hypersensitivity to tetracyclines.

Use at pregnancy and feeding by a breast
Minocycline gets through a placental barrier and is emitted with breast milk.
Do not apply in the second half of pregnancy and in the period of a lactation since minocycline causes discoloration of teeth, a hypoplasia of enamel and a growth disorder of bones of a skeleton of a fruit and the child.

Use at abnormal liver functions
It is contraindicated at an abnormal liver function.

Use for children
Minocycline causes discoloration of teeth, a hypoplasia of enamel and a growth disorder of bones of a skeleton of a fruit and the child therefore minocycline is not applied at children up to 8 years.


Overdose:

It is not described.


Storage conditions:

In the dry, protected from light place, at a temperature not above 25 °C.
To store in the place, unavailable to children.


Issue conditions:

According to the recipe


Packaging:

Капс. 50 mg; 100 mg: 20 or 30 pieces.



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