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medicalmeds.eu Medicines Immunoexcitant. Гепон®

Гепон®

Препарат Гепон®. ООО "Иммафарма" Россия


Producer: LLC Immafarm Russia

Code of automatic telephone exchange: L03AX

Pharm group: Immunostimulators

Release form: Liquid dosage forms. Powder for preparation of solution for intake.

Indications to use: HIV infection. Immunodeficiency. Candidiasis of mucous membranes. Skin candidiasis.


General characteristics. Structure:

Active ingredient: the synthetic peptide consisting of 14 amino-acid remains (formula Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu) about a pier. weighing 1818 дальтон.

Гепон® - highly effective and harmless medicine for strengthening of the weakened immunity and treatment of a wide range of infectious and inflammatory diseases.




Pharmacological properties:

Pharmacodynamics. Gepon is an immunomodulator and has antiviral effect. Immunopharmacological and antiviral mechanisms of effect of drug Gepon consist in the following:

  • Gepon causes products alpha and beta интерферонов
  • Gepon will mobilize and activates macrophages
  • Gepon limits production of cytokines of an inflammation (an interleykina 1, 8 and a factor of a necrosis of a tumor)
  • Gepon stimulates products of antibodies to various antigens of the infectious nature
  • Gepon suppresses replication of viruses
  • Gepon increases resistance of an organism concerning the infections caused by viruses, bacteria or mushrooms.

At the patients infected with HIV, Gepon reduces concentration of HIV in blood cells and in plasma, at the same time activates the immune responses specific concerning HIV. At most of the patients infected with HIV, treatment by Gepon leads to the following positive changes: the maintenance of CD4+T-and NK-cells increases, functional activity of neutrophils and CD8+ T increases - the cells which are key links of protection of an organism against bacteria, viruses and mushrooms development of the antibodies specific to HIV antigens, and also to antigens of causative agents of the opportunistic infections urgent for this patient amplifies.

The clinical effect of a course of treatment Gepon consists in the prevention of a recurrence of opportunistic infections within 3-6 months.

The short course of topical administration of Gepon allows to treat recurrent infections mucous and the skin caused by Candida mushrooms.

Gepon's use has antiinflammatory effect. Within 1-2 days after Gepon's use inflammation signs, in particular, reddening and puffiness, and also feeling of morbidity, burning, an itch in the field of inflamed mucous and skin significantly decrease. Gepon's use eliminates dryness of mucous.

The pharmacokinetics of drug was not studied in connection with its peptide nature.


Indications to use:

- for correction of the weakened immunity at immunodeficiency

- for treatment of HIV infection

- for increase in a host defense from infections, treatment and prevention

- the opportunistic infections caused by bacteria, viruses or mushrooms

- for treatment of infections mucous and the skin caused by Candida mushrooms

- for prevention of candidiasis mucous and skin as a result of therapy by antibiotics

- for reduction of an inflammation (reddening, hypostasis, an itch, burning, pain) mucous and skin and also dryness of mucous.


Route of administration and doses:

The recommended dose for adults and children of 12 years is also more senior makes 10 mg inside (per os) once a day, or 1-2 mg in the form of 0,02-0,04% of solution for local processing mucous and skin once a day.

For treatment of opportunistic infections at HIV infection or at other immunodefitsitiy states — carrying out a course of treatment with daily reception of Gepon on 10 mg inside within 1-3 months is recommended.

For treatment and prevention of infections mucous and the skin caused by Candida mushrooms — topical administration of Gepon by irrigation of affected areas mucous and skin of 0,02-0,04% by solution, a course 3 irrigations with an interval of 1-3 days between irrigations is recommended.

At a vulvovaginitis, an urethritis, a cervicitis at women apply irrigations of 0,02-0,04% Gepon's solution of a mucous vulva, vagina, a tserviks, and also lotion of the affected areas of skin adjacent to an entrance to a vagina.

At an urethritis and a balanoposthitis at men apply instillations of 0,02-0,04% Gepon's solution in an urethra and lotions on affected areas of skin. Mucous and skin repeat processing three times with an interval of 1-3 days.

For prevention of candidiasis mucous and skin as a possible complication at an intensive care antibiotics recommend to carry out irrigations (lotion) of 0,02-0,04% by Gepon's solution during a course of treatment an antibiotic.

For decrease in intensity of an inflammation mucous membranes should be irrigated with 0,02-4,04% Gepon's solution, and on the inflamed sites of skin to put gauze napkins, the moistened 0,02-0,04% Gepon's solution.


Features of use:

Pregnancy and feeding by a breast. There are no data on Gepon's impact on pregnant women. As well as in case of other medicines, Gepon it is not necessary to apply during pregnancy if only the advantages got by the patient do not exceed possible risk for a fruit. Gepon is not recommended for reception by nursing mothers.


Side effects:

Are not found.


Interaction with other medicines:

It is not described.


Contraindications:

Drug cannot be used at persons with hypersensitivity to Gepon. Children up to 12 years.



Storage conditions:

Drug is stored in the dry, protected from light place at a temperature not above +8 °C. List B. Period of storage 2 years. To store medicine in the place, unavailable to children!


Issue conditions:

According to the recipe


Packaging:

Drug is produced in the form of the sterile, lyophilized powder of white color on 1 mg, 2 mg or 10 mg in a bottle. Before the use contents of a bottle are dissolved in 5 ml. water or normal saline solution of 0,85% of NaCl.



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