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medicalmeds.eu Medicines Histamine drug. Vestikap

Vestikap

Препарат Вестикап. ООО "Озон" Россия


Producer: LLC Ozon Russia

Code of automatic telephone exchange: N07CA01

Release form: Firm dosage forms. Capsules.

Indications to use: Menyer's disease. Dizziness. Nausea. Vomiting. Decrease in hearing. Sonitus.


General characteristics. Structure:

Active agent: a betagistina dihydrochloride - 24,0 mg.

Excipients: lactoses monohydrate (sugar milk) - 129,0 mg; cellulose microcrystallic - 70,5 mg; potato starch - 30,0 mg; коповидон - 27,0 mg; sodium carboxymethylstarch - 15,0 mg, silicon dioxide colloid - 1,5 mg, magnesium stearate - 3,0 mg.




Pharmacological properties:

Agonist of H1-histamine receptors of vessels of an inner ear and antagonist of H3-histamine receptors of vestibular nuclei of the central nervous system (CNS). Due to relaxation of precapillary sphincters of vessels of an inner ear improves blood circulation in a vascular stripe of an inner ear.
Dozozavisimo reduces generation of action potentials in neurons of lateral and medial vestibular nuclei.
Accelerates recovery of vestibular function after a unilateral vestibular neurectomy, accelerating and facilitating the central vestibular compensation (due to antagonism with H3-histamine receptors).
Facilitates symptomatology at Menyer's syndrome and vestibular dizziness. The stable therapeutic effect occurs in 14 days.

Pharmacokinetics. Communication with proteins of plasma - 5% is absorbed quickly. Time of achievement of the maximum concentration in a blood plasma (TCmax) - 1 h.
It is metabolized to inactive metabolites: 2-piriiluksusny acid (main metabolite) and demitilbetagistina. 85-90% are removed by kidneys in the form of 2-pyridylacetic acid during 24 h removal of a betagistin and demitilbtagistin kidneys slightly. Intestines remove only a small part of a betagistin and its metabolites. At administration of drug with food the maximum concentration of a betagistin is lower, than at reception on an empty stomach. However the total bsorbation of a betagistin is identical in both cases that it indicates that meal only slows down absorption of a betagistin.


Indications to use:

The treatment of a syndrome of Menyer who is characterized by dizziness (which is followed by nausea and vomiting). decrease in hearing and sonitus.
Symptomatic treatment of vestibular dizziness (вертиго).


Route of administration and doses:

Inside, during food, on 1 capsule (24 mg) 2 times a day. Lecheiye long. The course of treatment is defined individually. Dose adjustment is not required from elderly people.


Features of use:

The therapeutic effect in some cases increases within several months from an initiation of treatment.
Influence on ability to driving and other mkhanizm: influence is absent or is insignificant.


Side effects:

- From the alimentary system: nausea, dispensiya, vomiting. abdominal pain, abdominal distention.
- Allergic reactions: hypersensitivity, including anaphylactic reactions.
- From integuments: Quincke's disease, small tortoiseshell, itch, rash.
- From a nervous system: headache.


Interaction with other medicines:

Interaction of a betagistin blockers of H1-histamine of receptors at odnovreme-menny use can theoretically influence an effektinost of one of these means.


Contraindications:

Hypersensitivity to components of lekartvenny drug, pregnancy, the lactation period, children's age up to 18 years, a pheochromocytoma, a lactose intolerance, deficit of lactase, a glyukozo-galaktozny malyabsorbation.
WITH CARE
Peptic ulcer of a stomach or 12-perstny gut (in the anamnesis), bronchial asthma.


Overdose:

Symptoms: nausea, abdominal pain. drowsiness (at reception in a dose to 640 mg); spasms, cardiopulmonary complications (at reception in a dose to 640 mg or in combination with other medicines).
Treatment: symptomatic.


Storage conditions:

In the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children.


Issue conditions:

According to the recipe


Packaging:

Capsules of 24 mg.
On 10, 20, 30 capsules in a blister strip packaging from a film and the polivinlkhloridny and printing aluminum foil varnished.
On 10, 20, 30, 40, 50 or 100 capsules in a container polymeric for medicines. One container or 1, 2, 3, 4 or 5 blister strip packagings together with the application instruction place in a pack from a cardboard.



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