Indigo carmine

General characteristics. Structure:

Active ingredient - indigo carmine (in terms of dry matter) 4,0 mg.

Excipients - formaldehyde sulphoxylate sodium a dihydrate of 0,5 mg, hydrocitrate sodium sexivihydrat of 1,0 mg, water for injections to 1,0 ml.

Pharmacological properties:

Pharmkakodinamika. Diagnostic means. Use is based on ability of this dye to be allocated quickly in not changed view with urine, without causing a renal failure.

Pharmacokinetics. Drug is removed preferential by kidneys, keeping blue color. Elimination begins within 10 min. after introduction. An elimination half-life - about 4-5 min.

Indications to use:

Research of secretory function of kidneys and dynamic activity of a renal pelvis and ureters. For identification of disturbances of integrity of a cavity and extent of the fistular courses.

Route of administration and doses:

Intravenously slowly, in the look which is warmed up to 37 °C - 0.4% aqueous solution, the adult - on 5-20 ml, children - on 1-3 ml, at impossibility to enter solution intravenously, enter intramusculary in number of 20 ml. With urine observe release of indigotin of a carmine by means of the cystoscope. At normal function of kidneys paint begins to be emitted from ureters in 2-3 min., the maximum removal is noted in 6-8 min., comes to an end in 1-1.5 h. Patients with an impaired renal function have an allocation less intensively and more in a slowed-up way. Vnutripolostno - 0.4% solution or part 5 ml of solution in 400 ml of 0.9% of solution of sodium of chloride.

Features of use:

At some patients increase in arterial pressure can be observed.

Side effects:

Allergic reactions. Increase in arterial pressure.

Interaction with other medicines:

Pharmaceutical it is incompatible with other drugs means, except for 0,9% of solution of sodium of chloride.

Contraindications:

Hypersensitivity to drug components, side effects on administration of indigo carmine in the anamnesis, pregnancy and the period of feeding by a breast, children's age up to 18 years.

Overdose:

Cases of overdose are noted.

Storage conditions:

In the dry, protected from light place, at a temperature from 15 °C to 25 °C.

To store in the places unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Solution for injections of 4 mg/ml on 5 ml in ampoules.

1, 2, 3, 4 or 5 ampoules in a blister strip packaging from a film polyvinyl chloride.

1 or 2 blister strip packagings together with the application instruction and the scarificator ampoule place in a cardboard pack.

10 ampoules together with the application instruction and the scarificator ampoule place in a cardboard pack with a corrugated insert.

When using ampoules with a point or a ring of a break the scarificator ampoule is not put.