Antisklerol

General characteristics. Structure:

Active ingredient: 300 mg of a biyen. 

Structure of a cover of the capsule of soft gelatinous: gelatin, glycerin, methylparahydroxybenzoate.

Biyen — a complex of ethyl ethers of the polyunsaturated fatty acids received from lipids of a micellar mushroom of Entomophthora virulenta. Biyen for 90 — 95% consists of higher fatty acids. Are a part of a biyen: ethyl ether of α-linolenic acid of acid (ω-3), ethyl ether of linolic acid (ω-6), ethyl ether of γ-linolenic acid of acid (ω-6), ethyl ether of arachidonic acid (ω-6), ethyl ether of eicosadienoic acid (ω-6), ethyl ether of eykozatriyenovy acid (ω-6), ethyl ether of palmitic acid (ω-7), ethyl ether of palmitoleic acid (ω-9), ethyl ether of oleic acid (ω-9), ethyl ether of stearic acid, ethyl ether of myristic acid.

Pharmacological properties:

Pharmacodynamics. The active beginning of Antisklerol is биен, rendering hypolipidemic, gipokholesterinemichesky, reparantny, cytoprotective action.

The unsaturated fatty acids which are Antisklerol's part, including essential (linoleic, α-linolenic and arachidonic) are important components of biomembranes and sources of autokoid — universal bioregulators of functional activity of cells and fabrics. Antisklerol is characterized by the balanced ratio of polyunsaturated fatty acids of families ω-6 and ω-3 rows.

Antisklerol's use provides decrease in concentration of cholesterol and triglycerides in blood serum. Antisklerol's ability to prevent formation of atherosclerotic plaques in vessels of elastic type and development of dystrophic changes in a liver and kidneys, necrotic processes in a myocardium is experimentally established.

Active ingredient of Antisklerol — биен — has reparative and cytoprotective properties, exerts the stimulating impact on process of healing of wounds, burns of skin and mucous membranes, is effective at treatment of a peptic ulcer of a stomach and duodenum.

Pharmacokinetics. Arachidonic acid is a predecessor of biologically active connections - eicosanoids: diene prostanoid (PGA2, PGV2 prostaglandins..., PGI2; PG-I2 prostacyclins, TOA2, TOB2 thromboxanes), tetrayenovy LTA4, LTV4 leukotrienes,…, LTF4; tetrayenovy lipotriyen, lipoksin, gidroperoksi-and hydroxyeicosahalf-yen acids.

Дигомо-γ-линоленовая acid through a 5-desaturaza turns into arachidonic acid, or itself directly participates in synthesis of eicosanoids.

α-linolenic acid acid in the course of biotransformation through a number of intermediate stages forms the long-chain derivatives – eykozapentayenovy acid and dokozageksayenovy acid. Besides, she can take part in formation of prostaglandins and leukotrienes through a number of intermediate stages. Triyenovy prostanoida are formed of α-linolenic acid of acid (PGA3, PGV3 prostaglandins..., PGI3; PG-I3 prostacyclins, TOA3, TOB3 thromboxanes), pentayenovy LTA5, LTV5, LTF5 leukotrienes; pentayenovy lipotriyena, lipoksina, gidroperoksi-and hydroxyeicosahalf-yen acids.

Linolic acid is a predecessor of biosynthesis of monoyenovy prostanoid (PGA1, PGV1 prostaglandins..., PGI1; PG-I1 prostacyclins, TOA1, TOB1 thromboxanes), and also triyenovy LTA3, LTV3, LTF3 leukotrienes; triyenovy lipotriyen, lipoksin.

Indications to use:

Hypercholesterolemia, gipertriglitseridemiya in the absence of effect of a dietotherapy, atherosclerosis (in complex therapy).

Route of administration and doses:

Inside, on 2 capsules (600 mg) 3-4 times a day in 30 minutes prior to food. The course of treatment makes not less than 8 weeks.

Features of use:

The expressed gipokholesterinemichesky, hypolipidemic effect is noted usually in 4-8 weeks of reception of Antisklerol.

Due to the moderate increase in a bleeding time (at reception of a high dose) observation of the patients receiving anticoagulating therapy is necessary (dose adjustment of anticoagulants can be required).

It is necessary to consider a possibility of increase in a bleeding time at patients with the increased risk of a hemorrhage (as a result of a severe injury, surgery).

At patients with a liver failure (especially at reception of high doses) regular control of function of a liver (ACT and ALT) is necessary.

The available experience of the research of a secondary endogenous gipertriglitseridemiya (which is especially not giving in to control of a diabetes mellitus) is limited.

Clinical experience of use for children, at patients is more senior than 70 years, at a liver failure, and also treatments of a gipertriglitseridemiya in combination with fibrata is absent.

Side effects:

At reception of a biyen the dispepsichesky phenomena (nausea, heartburn, a meteorism, an eructation bitterness or oil, smack of oil or bitterness in a mouth) which are not demanding special intervention and drug withdrawal can be noted. Besides, are possible lock/diarrhea; pains in epigastriums or in right hypochondrium; headaches; pains in lumbar area; increase of pains in precardiac area; exacerbations of gout.

The specified phenomena, as a rule, pass after drug withdrawal.

Interaction with other medicines:

Perhaps combined use of Antisklerol with nitrates, Amiodaronum, sotaloly, atenololy, metoprololy, verapamil, diltiazem, APF inhibitors (captopril, enalapril, fozinoprily), diuretics (hypothiazid, furosemide, indapamidy), nifedipine, Dipiridamolum, tiklopidiny, Mildronate, trimetazidiny, terazoziny, Phenazepamum, vitamins.

Drug reduces side effect by a mucous membrane of a GIT of non-steroidal anti-inflammatory drugs.

Peroral anticoagulants - risk of increase in a bleeding time.

The concomitant use with warfarin does not lead to development of hemorrhagic complications (however, at the combined reception or after the termination of a course of treatment drug it is necessary control of a prothrombin time.

The concomitant use from fibrata is not recommended.

Contraindications:

Hypersensitivity, exogenous gipertriglitseridemiya (hyper chylomicronemia of type 1), pregnancy, lactation period.

With care: chronic pancreatitis, diarrhea, the expressed liver failure, gout, a concomitant use from fibrata, peroral anticoagulants, severe injuries, surgeries (risk of increase in a bleeding time), age up to 18 years (efficiency and safety are not established), advanced age (70 years are more senior).

Overdose:

Cases of overdose of Antisklerol in capsules it is not installed.

Storage conditions:

In the place protected from moisture and light at a temperature from 8 °C to 15 °C. To store in the place, unavailable to children. Period of validity 2 years. Not to use after the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

Capsules on 300 mg in packaging No. 25 (in banks), No. 50 (No. 10х5 in blister strip packagings).