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Valerian forte

Препарат Валериана форте. ОАО "Борисовский завод медицинских препаратов" Республика Беларусь


Producer: JSC Borisovsky Plant of Medical Supplies Republic of Belarus

Code of automatic telephone exchange: N05CM09

Release form: Firm dosage forms. Tablets.

Indications to use: Neurasthenia. Nervous irritability. Sleep disorders.


General characteristics. Structure:

Active ingredient: 150 mg of extract of a valerian dense (with humidity of 25% that corresponds to the content of esters of carboxylic acids in terms of ethyl ether of acid valerenovy – not less than 2,25 mg).

Excipients: magnesium carbonate the main, potato starch, talc, gelatin, croscarmellose sodium.




Pharmacological properties:

Pharmacodynamics. Drugs of a valerian possess sedative action, facilitate approach of a dream and improve quality of a dream. These effects cannot be explained with action of any one component of a valerian. Some mechanisms of action which cause these clinical effects, were defined for various components of a root of a valerian (sesquiterpenoids, lignana, flavonoids) and adenosine receptors and 5-HT1A receptors include influence on GAMK-system, A1.

Sedation when using a valerian is shown slowly, but rather steadily and completely develops only at systematic and prolonged course treatment.

Pharmacokinetics. The pharmacokinetics of a valerian is studied insufficiently that it is connected with impossibility of exact identification of an effective agent of medicine.


Indications to use:

Apply as a calmative at the increased nervous irritability and sleep disorders.


Route of administration and doses:

To adults and children 12 years are more senior appoint inside 300-600 mg (2-4 tablets) 1-3 times a day after food.

At the increased nervous irritability reception to 3 times a day is recommended. At sleep disorders reception in 0,5 – 1 hour prior to a dream, and also, in case of need, additional administration of drug previously in the evening is recommended.

In cases of the emergency need of reduction of symptoms of a hyperphrenia and sleep disorders it is not recommended to use valerian drugs because of gradual development of effect. The recommended duration of treatment makes 2-4 weeks. If symptoms remain or worsen after 2 weeks of continuous use, it is necessary to see a doctor.


Features of use:

Use for children. Safety of use for children is younger than 12 years is not established.

Pregnancy and lactation. Safety of use during pregnancy and a lactation is not established. Due to the lack of sufficient data it is not recommended to apply during pregnancy and a lactation.

Influence on ability to driving of motor transport and control of mechanisms. During treatment it is necessary to refuse driving of motor transport and work with moving mechanisms.


Side effects:

Development of allergic reactions (skin rash, itch, hyperemia, cutaneous dropsy) is possible; developing of a headache, general weakness, decrease in working capacity, drowsiness, irritability, uneasiness, gastrointestinal frustration (nausea, abdominal pains). High doses can lead to bradycardia and arrhythmia, and also to decrease in motility of intestines (lock).

In case of the side reactions including which are not specified in the application instruction it is necessary to see a doctor.


Interaction with other medicines:

The valerian exponentiates action of others sedative and hypnagogues, anesthetics, psychotropic drugs, and also antispasmodics.

The combination of drugs of a valerian with synthetic sedatives demands medical observation.


Contraindications:

Hypersensitivity to a valerian or its components, pregnancy, the lactation period, children's age up to 12 years.


Overdose:

When using excessively high doses (more than by 20 times exceeding most recommended dose) there can be nonspecific symptoms connected with oppression of TsNS: slackness, block, drowsiness. In hard cases emergence of bradycardia and arrhythmia, abdominal pains of spastic character, feeling of constraint in breasts, dizzinesses, a tremor of hands and expansion of pupils is possible. The specific antidote does not exist.

Measures of the help include drug withdrawal, carrying out gastrointestinal lavage with use of absorbent carbon, magnesium sulfate reception inside for prevention of intestinal absorption of drug and ensuring laxative effect.


Storage conditions:

In the place protected from light and moisture, at a temperature not above 25 °C. To store in the place, unavailable to children. A period of validity - 2 years. Not to apply medicine after the termination of a period of validity.


Issue conditions:

Without recipe


Packaging:

On 10 tablets in a blister strip packaging; in packaging No. 10х3, No. 10х6.



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