Potassium chloride of 1%

General characteristics. Structure:

Acting вещесвто: 10 g of potassium of chloride, 50 g of glucose anhydrous in 1 l of solution.

Excipients: water for injections.

Pharmacological properties:

Pharmacodynamics. ABS (acid-base state) of blood normalizes, fills shortage of potassium. Activates many cytoplasmatic enzymes, regulates the intracellular osmotic pressure, protein synthesis, transport of amino acids, carrying out nervous impulses, reduction of skeletal muscles. Potassium ions cause urezheny ChSS, reduce sokratitelny activity, reduce conductivity, automatism and excitability of a myocardium. In small doses they expand coronary vessels, in big - narrow.

Potassium promotes increase in maintenance of acetylcholine and excitement of sympathetic department of TsNS. Has moderate diuretic effect. Increase in level of potassium reduces risk of development of toxic effect of cardiac glycosides on heart.

Pharmacokinetics. Potassium ions are allocated generally with urine, in a small amount with a stake, and also with saliva, bilious and pancreatic juice.

Indications to use:

Hypopotassemia (including connected using Hydrochlorthiazidum and other saluretics, with pernicious vomiting, a profuse diarrhea, etc.), intoxication drugs of a foxglove, arrhythmia of various origin (connected generally with electrolytic disturbances and an absolute or relative hypopotassemia), a gipokaliyemichesky form of a paroxysmal mioplegiya.

Route of administration and doses:

Solution of potassium of chloride is entered intravenously kapelno with a speed of 20-30 thaws a minute.

The dose and the scheme of treatment are established individually.

Features of use:

Apply with care at disturbances of AV of conductivity. In the course of treatment control of level of potassium in blood and an ECG is necessary, and at treatment of states, scarce on potassium, it is necessary to control carefully BRAIDS. At too bystry intravenous administration development of a hyperpotassemia which can potentially lead to a lethal outcome is possible.

Toxicity of drug increases at insufficiency of adrenal glands.

In need of use during pregnancy it is necessary to weigh the expected advantage for mother and potential risk for a fruit. In the period of a lactation it is necessary to resolve an issue of the breastfeeding termination.

Side effects:

Nausea, vomiting, diarrhea are possible. Seldom – a hyperpotassemia: arrhythmia, confusion of consciousness, feeling of alarm, feeling of numbness or a pricking in hands, ступнях or lips, an asthma or the complicated breath, unusual feeling of fatigue, weakness, heavy feeling or weaknesses in legs.

Interaction with other medicines:

At simultaneous use of salts of potassium about potassium saving diuretics and APF inhibitors the risk of development of a hyperpotassemia increases. Under the influence of drugs of potassium side effect of cardiac glycosides decreases, effect of quinidine on heart, and also undesirable action of Disopyramidum on cardiovascular system amplifies.

Contraindications:

Disturbance of secretory function of kidneys, total block of heart, hyperpotassemia of various etiology.

Overdose:

Precursory symptom of intoxication potassium are paresthesias. Clinical manifestations of a hyperpotassemia usually appear at potassium concentration in serum from 7 to 8 ¼Ý¬ó/l. Heavier symptoms (including paralysis of muscles and a cardiac standstill) develop at potassium concentration 9-10 ¼Ý¬ó/l. At overdose of drugs of potassium enter chloride sodium solution inside or intravenously; or intravenously 300-500 ml of solution of a dextrose with the maintenance of 10-20 PIECES of insulin in 1000 ml. If necessary carry out a hemodialysis and peritoneal dialysis.

Storage conditions:

In the dry, protected from light place at a temperature not above + 25 °C. Period of validity 2 years.

Issue conditions:

According to the recipe

Packaging:

Solution for infusions on 250 ml and 500 ml in polymeric containers.