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Naphthyzinum

Препарат Нафтизин. ФГУП "Московский эндокринный завод" Россия


Producer: Federal State Unitary Enterprise Moscow Endocrine Plant Russia

Code of automatic telephone exchange: R01AA08

Release form: Liquid dosage forms. Drops are nasal.

Indications to use: Rhinitis (cold). Allergic rhinitis (cold). Rinoskopiya. Nasal bleeding.


General characteristics. Structure:

Active ingredient: 0,5 mg or 1 mg of Naphthyzinum (nitrate naphazoline) in 1 ml of solution.

Excipients: boric acid, 1 M hydroxide sodium solution to pH 4,5, the water purified.




Pharmacological properties:

Pharmacodynamics. Vasoconstrictor. Excites alfa1-and alfa2-adrenoceptors, possesses antiedematous action. The vasoconstrictive effect is shown at local application on a mucous membrane of a nose.

At rhinitises facilitates nasal breath, reducing inflow of blood to venous sine.

Pharmacokinetics. The vasoconstrictive effect occurs in a few minutes and proceeds within several hours.


Indications to use:

At acute rhinitises, allergic rhinitises, for simplification of carrying out a rinoskopiya, for a stop of nasal bleedings.


Route of administration and doses:

Medicine is appointed intranazalno.

- At acute and allergic rhinitises the adult appoint on 1-3 drops 0,05-0,1% of solution 3-4 times a day. To children appoint 0,05% aqueous solution (or 0,025% solution, diluting 0,05% solution with the distilled water): from 1 го yes - up to 6 years - on 1-2 drops, from 6 to 15 years - on 2 drops 1-3 times a day.

- At a rinoskopiya apply to prolongation of surface anesthesia on 2-4 drops 0,1% of solution with 1 ml of anesthetic.

- At nasal bleedings enter into a nasal cavity tampons, the moistened 0,05% Naphthyzinum solution.


Features of use:

Pregnancy and lactation. It is not recommended to apply at pregnancy. Only in the period of a lactation (breastfeeding) use of drug is possible if the advantage for mother exceeds potential risk, for the child. It is necessary to consult with the doctor.

Can have resorptive effect.

At prolonged use expressiveness of vasoconstrictive action gradually decreases (the tachyphylaxis phenomenon), in communication with what it is recommended to take in 5-7 days of use a break for several days.

Influence on ability to manage vehicles and mechanisms. During treatment it is necessary to be careful at control of vehicles.


Side effects:

From the central nervous system: headache.

From cardiovascular system: tachycardia, increase in arterial pressure, reactive hyperemia.

From the alimentary system: nausea.

Local reactions: irritation, swelling of a mucous membrane of a nasal cavity, at use more than 1 week - hypostasis of a mucous membrane of a nasal cavity, atrophic rhinitis.

If the side effects specified in the instruction are aggravated, or you noticed any other side effects which are not specified in the instruction, report about it to the doctor.


Interaction with other medicines:

It is not necessary to apply along with monoamine oxidase inhibitors or within 14 days after the end of their use.


Contraindications:

Hypersensitivity, arterial hypertension, the expressed atherosclerosis, thyrotoxicosis, children's age till 1 year (for 0,05% of solution), chronic rhinitis, a serious illness of eyes, a diabetes mellitus, tachycardia, a concomitant use of monoamine oxidase inhibitors and> the period to, 14 days after the end of their use, age up to 18 years (for 0,1% of solution).


Overdose:

Symptoms: decrease in body temperature, bradycardia, increase in arterial pressure.

Treatment: symptomatic.


Storage conditions:

In the place protected from light at a temperature not above 15 °C (for drug in a tube droppers, a bottle droppers); in the place protected from light at a temperature not above 25 °C (for drug in bottles). To store in the places unavailable to children. A period of validity - 1 years in a tube droppers and in a bottle droppers. 2 years in bottles. After opening a tube dropper, a bottle dropper and a bottle - 1 month. Not to use after the expiry date specified on packaging.


Issue conditions:

Without recipe


Packaging:

Drops nasal 0,05% and 0,1%. 1,3 ml, 1,5 ml, 2 ml or 5 ml in a tube dropper polymeric. 1, 2, 4, 5 or 10 tube droppers with the application instruction of drug and the application instruction a tube dropper in a pack from a cardboard with partitions or without partitions. 5 ml or 10 ml in a bottle dropper polymeric. The 1 or 2 bottle dropper with the application instruction of drug and the application instruction a bottle - droppers in a pack from a cardboard. 5 ml in bottles glass. 1 bottle complete with a cover dropper in sterile execution and the application instruction of drug in a pack from a cardboard. 5 bottles in a blister strip packaging from a film polyvinyl chloride. A blister strip packaging complete with 5 covers droppers in sterile execution and the application instruction of drug in a pack from a cardboard.



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