Kaltsitonin-ratiofarm
Application instruction:
Kaltsitonin-ratiofarm – the antagonist of parathyroid hormone, exerts impact on a bone tissue and a homeostasis of calcium.
Form of release and structure
Dosage form – spray nasal dosed (on 14 or 28 doses in bottles).
Active ingredient – a calcitonin in the form of a calcitonin of a salmon, in 1 dose – 200 ME.
Auxiliary components: меглумин, трометамол, anhydrous citric acid, пропилпарагидроксибензоат, methylparahydroxybenzoate, water for injections.
Indications to use
- Ostealgia at ossifluence and/or osteosinging;
- Post-menopausal osteoporosis;
- Pedzhet's disease (deforming osteit);
- Zudek's syndrome or algodistrofiya – neurodystrophic pathologies which development is caused by reflex dystrophy, posttraumatic osteoporosis, a syndrome "shoulder brush", medicamentous neurotrophic disturbances, a kauzalgiya.
Contraindications
- Period of pregnancy and breastfeeding;
- Children's age;
- Hypersensitivity to drug components.
Route of administration and dosage
Kaltsitonin-ratiofarm will apply intranazalno.
The doctor makes purpose of drug on the basis of clinical indications.
The recommended dosing:
- Ossifluence and/or osteosinging: on 200 ME 1 times a day, at purpose of higher daily dose, it should be distributed on several injections. Full anesthesia can come after several days of therapy. The dose and frequency rate of introduction are adjusted individually;
- Post-menopausal osteoporosis: on 200 ME, or one injection, 1 time a day within 3 months and more. For prevention of a resorption of a bone tissue the concomitant use of vitamin D and drugs of calcium in acceptable doses is recommended;
- Pedzhet's disease: on 200-400 ME 1-2 times a day;
- Neurodystrophic pathologies: on 200 ME 1 times a day, the treatment period – 2-4 weeks. In case of need treatment is prolonged with purpose of 1 dose of drug of 1 times in 2 days, the period of therapy depends on dynamics of a condition of the patient, but no more than 6 weeks.
Side effects
Use of drug can cause side effects:
- Local reactions: xeromycteria, rhinitis, sinusitis, nasal bleeding;
- Others: often – nausea, dizziness, vomiting, rushes of blood to the person, an arthralgia; in isolated cases – a polyuria and a fever (passing), arterial hypertension, peripheral hypostases, reactions of hypersensitivity in the form of local or generalized skin rash.
Special instructions
The antibodies created as a result of prolonged use to a calcitonin do not influence its efficiency.
Treatment of patients with chronic rhinitis is recommended to be carried out under constant control of the doctor in connection with the raised resorption of active ingredient against the background of an inflammation of a mucous membrane of a nose.
It is necessary to carry out by the patient with suspicion on hypersensitivity to a calcitonin of a salmon before intranasal administration of drug skin tests by means of the diluted sterile solution of a calcitonin. The necessity of conducting skin tests is caused by the existing risk of development (at this category of persons) system allergic reactions, including an acute anaphylaxis.
During use of drug it is necessary to be careful at control of vehicles and mechanisms as action of Kaltsitonin-ratiofarma can cause dizziness in patients.
Medicinal interaction
Clinically significant interaction of drug with other medicines it is not established.
Terms and storage conditions
To store in the place, unavailable to children, at a temperature from 2 to 8 °C, after opening of a bottle – up to 25 °C.
The American scientists made experiments on mice and came to a conclusion that water-melon juice prevents development of atherosclerosis of vessels. One group of mice drank usual water, and the second – water-melon juice. As a result vessels of the second group were free from cholesteric plaques.
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