Kromofarm

Kromofarm – antiallergic drug.

Form of release and structure

The Kromofarm is released in the following dosage forms:

• Drops eye (on 10 ml in bottles, on 1 bottle in a cardboard pack);
• Spray nasal: transparent slightly yellowish or colourless liquid (on 15 ml in bottles, on 1 bottle in a cardboard pack).

Eye and spray nasal enters into structure of 1 ml of drops:

• Active agent: кромогликат sodium – 20 mg (in terms of 100% dry matter);
• Auxiliary components: sodium chloride, chloride a benzalkoniya, polysorbate 80, эдетат dinatrium, dodecahydrate dinatrium phosphate, a dihydrate dihydrosodium phosphate, water for injections.

Indications to use

The Kromofarm is appointed for treatment and prevention of the following diseases:

• Drops are eye: acute and chronic allergic conjunctivitis, including hay conjunctivitis and a spring keratoconjunctivitis;
• Spray nasal: acute and chronic seasonal or year-round allergic rhinitis, pollinosis.

Contraindications

• Age up to 4 years (for drops eye), up to 5 years (for spray nasal);
• Hypersensitivity to drug components.

Additional contraindications to use of Kromofarm in the form of spray nasal are:

• Heavy liver and/or renal failure;
• Polyps of a nasal cavity.

To pregnant women (in particular in the first trimester) and to the feeding women the Kromofarm is appointed only in cases when the expected advantage for health of mother is higher than risk for a fruit or the child.

Route of administration and dosage

Drops eye are appointed to adults and children 4 years on 1 drop in each eye, frequency rate of use – 4 times a day are more senior (if necessary increase up to 6-8 times a day is possible). After improvement of a state the frequency of an instillation can be reduced.

Therapy is continued before the termination of contact of the patient with allergen which caused development of a disease.

At seasonal allergic conjunctivitis therapy needs to be begun right after emergence of the first symptoms of a disease. It is also possible to apply Kromofarm preventively before emergence of pollen.

Duration of treatment is defined by a look and weight of disease.

The cap of a bottle should be screwed up as much as possible before the first use (the thorn located inside at the same time punctures an opening).

Spray nasal is appointed to adults and children 5 years on 1 injection in each nasal course, frequency rate of use – 3-4 times a day are more senior (adults in case of need can increase the frequency of use to 6 times a day). Before use of drug it is necessary to clean a nose accurately.

At seasonal allergic rhinitis therapy is recommended to be begun right after emergence of the first symptoms of a disease. Also perhaps preventive use of Kromofarm before contact of the patient with the known allergen. After improvement perhaps gradual lengthening of breaks between drug use.

The bottle during injection needs to be held vertically, a nozzle up. During injection it is recommended to make a small breath through a nose.

Duration of treatment is defined by a look and weight of disease. Drug withdrawal is recommended to be carried out gradually for 1 week.

Just before use of drops eye or spray nasal it is necessary to take a bottle with Kromofarm in hands to warm drug to body temperature.

Side effects

During use of drops eye development of the following side effects is possible:

• Organ of sight: a chemosis, a vision disorder, a blepharitis, irritation of a mucous membrane of an eye, feeling of a foreign body in an eye, the conjunctiva hyperemia, dacryagogue, dryness, skin rash around eyes, feeling of a pricking and burning and to clinically significant deviations or pathological changes of a conjunctiva do not bring in eyes which in 1-3 minutes pass independently;
• Respiratory disturbances: диспноэ;
• Allergic reactions: hypersensitivity reactions (at patients with hypersensitivity).

At use of Kromofarm in the form of spray nasal there can be following side effects:

• Respiratory system: burning or irritation of a mucous membrane of a nasal cavity, cough, frequent sneezing, rhinorrhea; seldom – nasal bleeding, easy dryness in a throat, the suffocation complicated or stidor breath, an ulceration of a mucous membrane of a nasal cavity;
• Immune system: extremely seldom – a Quincke's disease, anaphylactic reactions, the complicated swallowing, an arthralgia, puffiness of lips, faces, a century or language;
• Skin and hypodermic cellulose: skin itch, small tortoiseshell, skin rash, dieback;
• Digestive tract: a dysphagy, change of flavoring feelings, nausea, pain in a stomach;
• Central nervous system: headache, dizziness, migraine;
• Cardiovascular system: lowering of arterial pressure;
• Others: dacryagogue.

Chloride a benzalkoniya which can cause side effects in the form of hypersensitivity to it and taste changes is a part of drug as preservative.

At development during use of Kromofarm of side effects it is necessary to consult with the attending physician.

At long therapy it is regularly necessary to control a functional condition of a liver and kidneys.

Special instructions

In the period of an aggravation of chronic process and at an acute inflammation the Kromofarm should be applied along with antihistaminic drugs or corticosteroids.

The Kromofarm needs to be applied regularly. Treatment is recommended to be begun before contact with allergen and to continue throughout all period of validity of allergen.

Before use of drops eye rigid contact lenses need to be removed. Again it is possible to use them 15 minutes later.

The accidental proglatyvaniye of Kromofarm is safe, and no special measures, except medical observation, in this case are required.

At disturbance of integrity of a bottle with drops or spray, and also in case of solution opacification the Kromofarm should not be used.

For some time after the Kromofarm instillation in eyes it is necessary to abstain from performance of work, requiring special attention (development of a short-term vision disorder is possible).

Medicinal interaction

The Kromofarm mutually strengthens effect of other antiasthmatic and antiallergic means: glucocorticoids, beta-adrenergic agonists, antihistaminic drugs and theophylline. At co-administration the dose of the last can be lowered.

Terms and storage conditions

To store in protected from light, the place, unavailable to children, at a temperature of 15-25 °C.

Period of validity – 3 years.

After opening of a bottle the Kromofarm can be applied within 28 days.