Capsules: size No. 2, firm gelatinous, yellow color; in capsules – mix from granules and powder white with a yellowish shade or white color (on 10 pieces in a blister strip packaging, in a cardboard pack of 2, 3 or 6 packagings);
Solution for intravenous (in/in) and intramuscular introduction (in oil): in the form of the colourless or slightly painted transparent liquid (on 2 ml in glass ampoules of dark color, in a blister strip packaging on 5 ampoules, in a cardboard pack 1, 2 or 4 packagings).

Active ingredient of Meksikor – ethylmethylhydroxypyridine succinate:

1 capsule – 100 mg;
1 ml of solution – 50 mg.

Auxiliary components:

Capsules: lactose (sugar milk), cellulose microcrystallic, potato starch, magnesium stearate, povidone (polyvinylpirrolidone low-molecular medical 12600±2700);
Solution: succinic acid, dinatrium эдетат, water for injections.

In addition as a part of capsules: gelatin, dye quinolinic yellow (E104), titanium dioxide (E171), dye sunset yellow (E110).

Indications to use

Ischemic stroke;
Easy and moderate cognitive frustration of various etiology;
Distsirkulyatorny encephalopathy.

Besides, Meksikor's use is shown as a part of complex therapy:

Capsules: coronary heart disease;
Solution: since the first days of an acute myocardial infarction.

Contraindications

The expressed renal failure and/or a liver;
Period of pregnancy and breastfeeding;
Age up to 18 years;
Hypersensitivity to drug components.

Route of administration and dosage

Capsules:
Capsules accept inside. The recommended dosing at the beginning of therapy – on 1 capsule 3 times a day. Depending on portability and a clinical condition of the patient the dose of drug should be raised gradually, at the same time one-time reception should not exceed 2 capsules, and a daily allowance – 8 capsules.

Use duration as a part of complex therapy of disturbances of blood circulation of a brain and coronary heart disease has to make 1,5-2 months and more. Drug withdrawal is made gradually, by a daily dose decline of Meksikor on 1 capsule. It is desirable to plan carrying out the repeated courses recommended by the doctor for the spring and autumn period.

As a part of complex therapy of easy or moderate cognitive frustration and distsirkulyatorny encephalopathy drug is appointed on 1 capsule by 3-4 times a day, without restriction of the period of use.

Solution for intravenous and intramuscular administration:
Intravenously it is slowly struyno possible to administer the drug (5 and more minutes) or kapelno. For infusional introduction drug is mixed from 100-150 ml of normal saline solution or 5% of solution of a dextrose (glucose). Not to allow development of side effects duration of infusion has to make 0,5-1,5 hours. The recommended daily dosing is defined at the rate of 6-9 mg on 1 kg of weight of the patient, but no more than 800 mg a day. The received dose shares on 3 (in/in or in oil) introductions in days, every 8 hours, at the same time the single dose of Meksikor should not exceed 250 mg.

From the first days of an acute myocardial infarction use of drug is shown within 14 days as a part of the traditional therapy consisting of co-administration of beta adrenoblockers, nitrates, antiagregant and anticoagulants, inhibitors of an angiotensin-converting enzyme (APF), trombolitik and the appropriate symptomatic means. For achievement of clinical effect the first 5 days it is recommended in/in introduction then it is possible to pass to administration of solution in oil.

The recommended dosing at an ischemic stroke (as a part of complex treatment): on 200-300 mg 2-3 times a day in a look in/in drop introductions for the first 2-4 days of therapy, then – on 100 mg 3 times in days in oil. A course of treatment – 10-14 days with the subsequent transfer of the patient into oral administration of drug on 1 capsule 2 times a day during the first 14 days and 1 capsule 3 times a day during the next 7 days. Duration of repeated courses and frequency of their appointment are determined by the doctor on the basis of clinical indications.

For treatment of distsirkulyatorny encephalopathy in a phase of a decompensation 2-3 times a day within 14 days, then on 100 mg of 1 times days in oil during the next 14 days are shown in/in jet or drop introduction of Meksikor on 100 mg. 1 capsule 2-4 times a day is recommended to continue treatment by administration of drug inside in a dose. Duration and frequency of repeated courses are determined by the attending physician. For prevention of distsirkulyatorny encephalopathy to the patient appoint administration of solution in oil on 100 mg 2 times a day.

The recommended dose for easy and moderate cognitive frustration – on 100-300 mg in days in oil within 14 days. In case of need therapy can be continued by administration of drug inside on 1 capsule 2-4 times a day. Frequency rate of reception is recommended by the doctor, at the same time the course of treatment has no temporary restrictions.

Side effects

Prolonged use of Meksikor can cause side effects:

Nervous system – sleep disorders in the form of drowsiness or disturbance of backfilling;
The alimentary system – a meteorism; at use of solution for in/in and injections in oil – nausea.

Reception of capsules is usually transferred well, seldom their action can become the reason of the following states:

Alimentary system: dryness in a mouth, dyspepsia, nausea, diarrhea (side effects have passing character);
Others: allergic reactions.

High speed in/in administrations of drug, especially jet, can cause the following by-effects of tranzitorny character:

Respiratory system: feeling of shortage of air and discomfort in a thorax, irritation in a throat;
Alimentary system: metal smack and dryness in a mouth;
Others: feeling of the spreading heat in all body.

Special instructions

Parenteral use of Meksikor at treatment of an acute myocardial infarction and ischemic stroke, a chronic form of disturbance of cerebral circulation (distsirkulyatorny encephalopathy) always should be continued by administration of drug inside (on 1 capsule 3 times a day), it allows to provide preservation of the reached clinical effect. Duration of reception of capsules is determined by the doctor.

During reception of capsules the patient needs to be careful at control of vehicles and occupation potentially dangerous types of activity which performance demands the increased speed of psychomotor reactions and concentration of attention.

Medicinal interaction

Simultaneous use of Meksikor promotes strengthening of effect of benzodiazepine anxiolytics, protivoparkinsonichesky means (including a levodopa), carbamazepine and other anticonvulsants.

Drug exponentiates hypotensive activity of beta adrenoblockers and APF inhibitors, anti-anginal effect of nitrates.

Antioxidant effect of drug leads to decrease in toxic effect of ethanol.