Oxacillinum

Oxacillinum – antibiotic drug of group of penicillin.

Form of release and structure

Dosage forms of release of Oxacillinum:

• Powder for preparation of solution for intramuscular and intravenous administration: hydroscopic, white or almost white (in bottles, on 1, 5, 10 or 50 bottles in a cardboard pack);
• Powder for preparation of solution for intramuscular introduction: hydroscopic, white or almost white (in bottles, on 1, 5 or 10 bottles in a cardboard pack);
• Tablets (on 10 pieces in blister strip packagings, on 2 packagings in a cardboard pack; on 20 pieces in dark glass jars, after 1 bank in a cardboard pack).

The structure of 1 bottle with powder for preparation of solution for in oil and in/in introductions includes active agent: Oxacillinum – 0,25, 0,5 or 1 g (in the form of sodium salt).

Active agent is a part of 1 bottle with powder for preparation of solution for introduction in oil: Oxacillinum – 0,25 or 0,5 g (in the form of sodium salt).

Active agent is a part of 1 tablet: sodium Oxacillinum – 0,25 g.

Indications to use

Oxacillinum is appointed for treatment of the infectious diseases caused by gram-positive microorganisms which produce and do not produce a penicillinase, namely the postoperative and wound fevers, sepsis, meningitis, a pyelitis, abscess, cholecystitis, phlegmons, cystitis, osteomyelitis infected burns, sinusitis, a bacterial endocarditis.

Contraindications

Contraindication to use of Oxacillinum is existence of hypersensitivity to drug components, and also to others beta лактамным to antibiotic means.

Care is demanded by purpose of Oxacillinum from patients with such diseases / states as:

• Bronchial asthma and/or allergic reactions (anamnestic data);
• Renal failure in a chronic current;
• Coloenteritis against the background of use of antibiotics (anamnestic data).

Women during pregnancy and chest feeding can appoint Oxacillinum only according to vital indications after a ratio of the expected advantage for health of mother with potential risk for the fruit/child. In the period of a lactation for the period of therapy breastfeeding needs to be interrupted.

Route of administration and dosage

Injection solution
Oxacillinum is applied intramusculary or intravenously.

The recommended mode of dosing (daily dose):

• Adults and children of 6 years: 2-4 g;
• Children of 2-6 years: 2 g;
• Children from 3 months to 2 years: 1 g;
• Children up to 3 months – 0,06-0,08 g/kg;
• Premature and newborn children: 0,02-0,04 g/kg.

It is necessary to enter solution of Oxacillinum each 4-6 hours (4 times a day).

The average duration of a course – 7-10 days, at treatment of severe forms of a disease (sepsis, a septic endocarditis) its increase up to 2-3 weeks and longer is possible.

Way of preparation and administration of solutions:

• Intramusculary: 0,25 g of powder / 1,5 water ml for injections, 0,5 g of powder / 3 water ml for injections;
• Intravenously struyno: 0,25 or 0,5 g of powder / 5 water ml for injections or 0,9% of solution of sodium chloride; the drug needs to be administered slowly (for 5-10 minutes);
• Intravenously kapelno: cultivation to concentration of 0,0005-0,002 g/ml of 0,9% solution of sodium chloride or 5% dextrose solution; Oxacillinum is entered with a speed of 60-100 thaws a minute for 1-2 hours.

Tablets
Oxacillinum is accepted inside.

The doctor sets the dosing mode individually.

The recommended scheme of administration of drug (single dose):

• Adults and children weighing more than 40 kg: on 0,5-1 g of 4-6 times a day (each 4-6 hours);
• Children weighing up to 40 kg: on 0,0125-0,025 g/kg 4 times a day (each 6 hours).

Side effects

• Alimentary system: dyspepsia in the form of nausea, diarrheas, vomitings, oral cavity candidiasis, a pseudomembranous coloenteritis, a hepatotoxic action in the form of a hyperthermia, nausea, vomitings, yellownesses of skin or scleras, increases in activity of hepatic transaminases (develops at purpose of high doses more often – from 6 g a day);
• Urinogenital system: vaginal candidiasis, hamaturia, intersticial nephrite, proteinuria;
• Allergic reactions: urticaria, skin itch; more rare – a bronchospasm, a Quincke's disease; in rare instances – an eosinophilia, an acute anaphylaxis.

Special instructions

It is inexpedient to apply Oxacillinum at treatment of the infections caused by microorganisms, sensitive to effect of benzylpenicillin.

Medicinal interaction

During therapy increase in doses of a folinat of calcium (is an antidote of antagonists of folic acid) and its more long use can be required.

Oxacillinum combination to ampicillin or benzylpenicillin is rational as the action spectrum increases.

The combined use with other drugs having a hepatotoxic action should be avoided.

At the combined use of Oxacillinum with some drugs the following effects can be observed:

• Laxative medicines and antacids: reduction of absorption of Oxacillinum;
• Methotrexate: increase in its toxicity;
• Bacteriostatic antibiotics: decrease in efficiency (the combined use is not recommended);
• Drugs which block canalicular secretion: increase in concentration of Oxacillinum in blood.

Terms and storage conditions

To store in the place, dry, unavailable to children, at a temperature up to 25 °C.

Period of validity – 2 years.