Peritolum

Peritolum – the drug having antihistaminic, antiserotoninovy and antiallergic effect.

Form of release and structure

Dosage forms of release of Peritolum:

• Syrup: light orange, transparent, has a fruit smell (tutti-frutt) and sweet taste (on 100 ml in dark glass bottles, on 1 bottle in a cardboard pack complete with a dosing cap);
• Tablets: flat, round, with a facet, white or grayish-white, on one of the parties – risk, on another – the arc-shaped engraving of "PERITOL", almost without or inodorous (on 10 pieces in blisters, on 2 blisters in a cardboard pack).

Is a part of 1 ml of syrup:

• Active ingredient: a cyproheptadine hydrochloride – 0,4 mg (cyproheptadine hydrochloride sexivihydrat – 0,43 mg);
• Additional components: 96% ethanol, sorbic acid, sucrose, sodium hydroxide, acetic ice acid, aromatic additive of a tutti-frutta, dye a sunset yellow C.I.15895 E.110 (ariavit sanst yellow), the purified water.

Is a part of 1 tablet:

• Active ingredient: a cyproheptadine hydrochloride – 4 mg (cyproheptadine hydrochloride sexivihydrat – 4,3 mg);
• Additional components: potato starch, magnesium stearate, talc, gelatin, monohydrate of lactose.

Indications to use

• Skin diseases: neurodermatitis, contact dermatitis and toksikodermiya, eczema;
• Diseases of allergic genesis: Quincke's disease of Quincke, hay fever, small tortoiseshell, serum disease;
• Vasculomotor rhinitis;
• Anorexia of various genesis;
• The headaches having a vascular etiology (a histamine headache, migraine);
• Allergic reactions to hemotransfusion, administration of drugs, administration of radiopaque substances.

Contraindications

• Closed-angle glaucoma;
• Urination delay;
• Predisposition to hypostases;
• Prostate adenoma;
• Simultaneous use with monoamine oxidase inhibitors;
• Age up to 6 months (syrup) or 2 years (tablet);
• Pregnancy and period of a lactation;
• Hypersensitivity to drug components.

Route of administration and dosage

Peritolum has sedative effect, especially in an initiation of treatment therefore it is recommended to accept the first dose of drug after a dinner.

Syrup
The recommended dosing mode for children (daily dose):

• 6-24 months: 0,4 mg/kg;
• 2-6 years: 6 mg (on 2 mg 3 times a day, as much as possible – 8 mg);
• 7-14 years: 12 mg (on 4 mg 3 times a day).

At anorexia to children usually appoint from 6-8 mg a day.

The average adult daily dose of Peritolum makes 12 mg (on 4 mg 3 times a day), maximum – 32 mg.

The scheme of administration of drug depending on a disease (daily dose):

• Chronic small tortoiseshell: 6 mg in 3 receptions;
• Anorexia: 12 mg in 3 receptions;
• Attacks of acute migraine: 4 mg once. If the effect is absent, the single dose can be accepted repeatedly in 30 minutes. Within 4-6 hours the general dose of Peritolum should not exceed 8 mg.

As a maintenance therapy, as a rule, appoint 3 times a day 4 mg.

At functional disturbances of a liver the dose of Peritolum should be reduced.

Behind a condition of elderly patients during therapy carrying out systematic observation is recommended.

5 ml of syrup correspond to 2 mg of Peritolum.

Tablets
The recommended dosing mode for children (daily dose):

• 2-3 years: 0,25 mg/kg;
• 3-6 years: 4-6 mg in 2-3 receptions, as much as possible – 12 mg; at anorexia – from 6 to 8 (as much as possible) mg in 3 receptions;
• 7-14 years: 8-12 mg in 2-3 receptions, as much as possible – 16 mg.

The adult daily dose usually makes 12 mg in 3 receptions.

The scheme of administration of drug depending on a disease (daily dose):

• Chronic small tortoiseshell: on 1/2 tablets 3 times a day;
• Anorexia: on 1 tablet 3 times a day;
• Attacks of acute migraine: 1 tablet once. If the effect is absent, the single dose can be accepted repeatedly in 30 minutes. Within 4-6 hours the general dose of Peritolum should not exceed 8 mg.

As a maintenance therapy, as a rule, appoint 3 times a day on 1 tablet.

Side effects

Syrup

• Cardiovascular system: tachycardia, hypotonia;
• Central nervous system: ataxy, drowsiness, headache, visual hallucinations, dizziness, concern, tremor;
• Hemopoietic system: leukopenia, hemolitic anemia, agranulocytosis;
• Alimentary system: vomiting, nausea, dryness in a mouth, diarrhea;
• Allergic reactions: Quincke's edema, dieback, small tortoiseshell, photosensitivity.

Tablets
During therapy development of tranzitorny drowsiness is possible (the therapy termination in some cases is required).

Development of such side reactions as is less often noted: a headache, an ataxy, nausea, an enanthesis, dryness in a mouth, uneasiness, confusion of consciousness, visual hallucinations, dizziness, excitement.

Special instructions

At treatment of children and patients of advanced age the special attention as this group of patients shows big sensitivity to side effects of antihistaminic drugs is required.

It is necessary to be careful at purpose of Peritolum the patient with cardiovascular diseases, and also in the presence of anamnestic instructions on bronchial asthma, a hyperthyroidism or arterial hypertension.

The use of the drinks containing alcohol during therapy contraindicated.

When carrying out complex preoperative training of patients Peritolum under strict control of the doctor can be applied along with narcotic analgetics, anxiolytics (Peritolum exponentiates action jointly of the applied means and prevents development of undesirable actions of a histamine (in the form of arterial hypotension, a bronchospasm) which will be allocated during operation as a result of traumatization of body tissues).

128 mg of lactose are a part of 1 tablet that patients need to consider with a lactose intolerance, a galactosemia or a syndrome of glyukozo-galaktozny malabsorption.

During use of Peritolum in any dosage form to manage vehicles and the equipment, and also to perform the works connected with the increased risk does not follow.

Medicinal interaction

At the combined use of Peritolum with some drugs / substances the following effects can be observed:

• Fluoxetine and other inhibitors of the return neyronalny serotonin reuptake: decrease in efficiency of antidepressants;
• Caffeine, Phenaminum: decrease in the oppressing effect of cyproheptadine on the central nervous system;
• The ethanol, somnolent, sedative, anxiolytic means and other substances oppressing the central nervous system: the additive action (constant observation of a condition of patients is required, if necessary therapy is cancelled);
• Monoamine oxidase inhibitors, and also tricyclic antidepressants: prolongation and strengthening of m-holinoblokiruyushchego of effect of cyproheptadine and strengthening of the oppressing influence on the central nervous system (the combined use with monoamine oxidase inhibitors is contraindicated).

Terms and storage conditions

To store in the place, unavailable to children, at a temperature of 15-25 °C.

Period of validity:

• Syrup – 3 years;
• Tablets – 5 years.