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Polyvinylpirrolidone

Polyvinylpirrolidone – water soluble polymer from N-vinylpyrrolidone monomer, В сухом виде поливинилпирролидон имеет вид белого порошка also known as поливидон or povidone.

Polyvinylpirrolidone was for the first time synthesized by Walter Reppe, and the patent for it was registered in 1939 as on one of the most interesting derivatives of acetylene in chemistry. Polyvinylpirrolidone was originally used as blood plasma substitute, and then found application in the most various industries of medicine, pharmacy, cosmetology and industrial production.

Properties of polyvinylpirrolidone

We will dissolve polyvinylpirrolidone in water and other polar solvents. Polyvinylpirrolidone in a dry form has an appearance of the white or light yellow puff hydroscopic powder which is easily absorbing up to 40% of the weight in atmospheric water.

Molecular formula of polyvinylpirrolidone – C6H9NO, molar weight – 2.500 - 2.500.000 grams/mol, density – 1,2 g/cm ³, melting temperature – 150-180 °C.

Polyvinylpirrolidone use

In medicine polyvinylpirrolidone was used as blood plasma substitute after 1950. Now it is used as binding substance in many pharmaceutical tablets, it is easily dissolved in water and alcohol, and also due to formation of water-soluble complexes improves solubility and bioavailability of medicinal substances (chemotherapeutic means, analgetics and antibiotics).

Polyvinylpirrolidone with addition of iodine forms a complex, the called povidone-iodine having disinfecting properties. This complex is used in various medicines and hygienic means, such as solutions, ointments, vaginal suppositories, liquid soaps and surgical srubs.

Polyvinylpirrolidone also has broad use in quality:

Glue in glue pencils and thermofusible glues;
Special additive for batteries, ceramics, fiber glasses, ink and papers for an inkjet printing;
Emulsifier and baking powder for polymerization in solution;
Permission enlarger in photoresist of electron beam tubes;
Element for production of membranes, such as dialysis and filters for water purification;
The binding agent and kompleksoobrazovatel in the agro-industrial industry, such as culture of protection, treatment and covering of seeds;
Thickener in the bleaching tooth gels;
Supportive application for increase in solubility of drugs in liquid and semi-fluid dosage forms (syrups, soft gelatin capsules) and as recrystallization inhibitor.

Polyvinylpirrolidone is also used in solutions for contact lenses and in personal hygiene means, such Поливинилпирролидон используется в растворах для контактных линз as shampoos, shower gels, hair conditioners, body scrubs, toothpastes, varnishes and hair gels.

In the food industry the stabilizing properties polyvinylpirrolidone allow to use it as E1201 nutritional supplement which is a glazirovatel, sweetener, a baking powder and the regulator of acidity.

The adsorbing properties polyvinylpirrolidone allow to use it as a part of means for an organism detoxication.

Polyvinylpirrolidone is applied to processing of wine materials and can be applied to bodying of drinks, clarification of white wine and some grades of beer.

In molecular biology polyvinylpirrolidone is used as the blocking agent in Sauzern-blot the analysis as a component of solution of Denkhardt.

Harm polyvinylpirrolidone

As a rule, polyvinylpirrolidone is considered safe and does not cause serious side effects, however cases of allergic reactions to polyvinylpirrolidone, especially concerning its hypodermic use and situations when polyvinylpirrolidone comes into contact with autologous serum and mucous membranes were recorded.

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