Pradzhisan

Pradzhisan – the hormonal medicine containing progesterone which is applied at lyuteinovy insufficiency.

Pharmacological action of Pradzhisan

Progesterone (active component of Pradzhisan) – the hormone of a yellow body causing transition of a mucous membrane of a uterus from a proliferation phase in secretory.

Pradzhisan promotes:

• To reduction of excitability and contractility of muscles of a uterus and uterine tubes;
• To increase in utilization of glucose;
• To development of a normal endometria;
• To increase in development of Aldosteronum;
• To accumulation in a glycogen liver.

At vaginal use of Pradzhisan progesterone contacts in a vagina a mucous membrane, being continuously released for at least three days.

Release form

Pradzhisan release in a look:

• Homogeneous white vaginal gel which 1 g contains 80 mg of active agent (progesterone). In vaginal plastic applicators 1,35 disposable;
• Light yellow oval capsules with oily suspension of white color. Each capsule contains progesterone in number of 100 mg and 200 mg. On 10 capsules in the blister.

Pradzhisan's analogs

On active component Progesterone, Iprozhin, Kraynon, Utrozhestan, and on the action mechanism – Medroksiprogesteron-LENS and Pregnenoldione капронат treat Pradzhisan's analogs.

Indications to Pradzhisan's use

Pradzhisan according to the instruction is shown to use at treatment:

• The infertility caused by lyuteinovy insufficiency;
• Secondary amenorrhea and dysfunctional uterine bleedings which are caused by deficit of progesterone.

Besides, Pradzhisan is effective for maintenance of a lyuteinovy phase in usage time of additional methods of a reproduction and as replaceable hormonal therapy in a postmenopause along with oestrogenic medicines.

Contraindications

Pradzhisan according to the instruction it is contraindicated to apply at:

• Vaginal bleedings of the obscure etiology;
• Malignant tumors of generative organs or mammary glands, and also in suspicion cases on them;
• Porphyrias;
• Incomplete abortions;
• Acute fibrinferments or thrombophlebitises, and also clotting diseases and acute disorders of cerebral circulation;
• Hypersensitivity to progesterone or auxiliary components of medicine.

Besides, capsules Pradzhisan should not be accepted against the background of a serious illness of a liver, including hepatocellular cancer, hepatitis, cholestatic jaundice. This caution belongs both to the current diseases, and in the anamnesis in cases when indicators of function of a liver did not return to normal values.

With care appoint Pradzhisan against the background of:

• Bronchial asthma;
• Diseases of cardiovascular system;
• Chronic renal failure;
• Depressions;
• Arterial hypertension;
• Diabetes mellitus;
• Migraines;
• Epilepsies;
• Giperlipoproteinemiya.

Pradzhisan's use at pregnancy and in the period of a lactation

Pradzhisan's use at pregnancy is not contraindicated, however in the instruction it is specified the existing risk at reception of a medicine in the first four months of pregnancy. Cases of anomalies in development of the child by results of numerous epidemiological researches were not revealed.

However it is necessary to consider that Pradzhisan at pregnancy in the second and third trimesters can cause development of diseases of a liver in future mother.

There are no reliable data about influence of a medicine on the child during breastfeeding.

Pradzhisan route of administration

At Pradzhisan's use in the form of capsules inside against the background of insufficiency of progesterone, as a rule, appoint a daily dose of 200-300 mg which is divided into 2 receptions (in morning and evening). Duration of therapy is determined by the attending physician.

Against the background of insufficiency of a lyuteinovy phase which includes a fibrous and cystous mastopathy, a premenstrual syndrome, a dysmenorrhea and a premenopauza the daily dose of Pradzhisan varies from 200 to 400 mg which is accepted for ten days, as a rule, from the seventeenth to the twenty sixth day of a cycle.

In peri-and a postmenopause at replaceable hormonal therapy accept on one capsule of Pradzhisan (200 mg) a day for 10-12 days against the background of reception of estrogen.

Capsules Pradzhisan apply Vaginalno:

• At absolute deficit of progesterone at women with the absent ovaries – for two months according to the individual scheme;
• During preparation for extracorporal fertilization for support of a lyuteinovy phase – on 200-600 mg a day throughout the first two trimesters of pregnancy. At threat of abortion and for prevention of the usual abortions connected with insufficiency of progesterone – on 200-400 mg;
• For support of a lyuteinovy phase against the background of the spontaneous or induced menstrual cycle, and also at infertility which is connected with dysfunction of a yellow body – for 10 days on 200-300 mg a day.

At Pradzhisan's use in the form of gel usually appoint on one applicator a day (90 mg of progesterone). The medical course depends on indications:

• At the lyuteinovy insufficiency causing infertility – 10 days;
• In the course of use of additional reproductive technologies for maintenance of a lyuteinovy phase – for 12 weeks after pregnancy confirmation.

Cases of overdose by Pradzhisan in the instruction are not described.

Medicinal interaction of Pradzhisan

At Pradzhisan's use in its efficiency can reduce barbiturates, hydantoin, griseofulvin, carbamazepine, absorbent carbon and rifampicin.

Active component of a medicine increases pharmacological and therapeutic effects, and also toxic effect of theophylline, cyclosporine and troleandomitsin.

At vaginal use of Pradzhisan it is not recommended his combination to any other drugs to avoid disturbance of release and absorption of progesterone.

Side effects of Pradzhisan

In the first month of treatment of the capsule Pradzhisan, according to reviews, can cause tension in mammary glands and reduction of a normal menstrual cycle.

In several hours after reception drowsiness, insignificant dizziness and nausea can be observed. Expressiveness of these effects, as a rule, decreases when changing a dosage form of a medicine.

Besides, capsules Pradzhisan, according to reviews, can cause:

• Migraine;
• Jaundice;
• Feeling of fatigue;
• Liquid delay;
• Skin rash;
• Headache;
• Itch.

At Pradzhisan's use in the form of vaginal gel there can be following disturbances:

• Abdominal pains (alimentary system);
• Drowsiness and headache (nervous system);
• Intermenstrual bleedings, morbidity of mammary glands, irritation of a mucous membrane of a vagina in the place of application (reproductive system).

The most typical allergic reaction during Pradzhisan's use, according to reviews, is skin rash.

Storage conditions

Pradzhisan treats a number of gestagenny medicines of a prescription issue with a period of validity to 24 months on condition of observance of standard storage conditions at a temperature of 15-25 degrees Celsius.