Safotsid

Composition of drug

Safotsid is the drug containing a combination of three operating dosage forms in the form of separate tablets. At the moment Safotsid has no structural analogs. According to Safotsid's instruction, the following active ingredients are a part of drug:

• Flukonazol. 1 tablet containing active ingredient флуконазол - 150 mg, excipients: calcium phosphate double-base (anhydrous), sodium of a kroskarmelloz, magnesium stearate, silicon dioxide colloid, "crimson varnish 4R" dye;
• Azithromycin. 1 tablet coated, containing active ingredient azithromycin (in the form of a dihydrate) 1 g. Auxiliary components: sodium lauryl sulfate, croscarmellose sodium, silicon dioxide colloid (anhydrous), K30 povidone, magnesium stearate. Cover: a gipromelloza, diethyl phthalate, magnesium hydrosilicate the purified (talc), titanium dioxide, a macrogoal 4000, "crimson varnish 4R" dye;
• Seknidazol. 2 tablets, coated, containing active ingredient секнидазол 1 g. Auxiliary components: starch corn, MKTs, silicon dioxide colloid (anhydrous), the talc purified sodium starch glycollate, povidone 30, magnesium stearate. Cover: a gidroksipropilmetiltsellyuloza, the diethyl phthalate, talc purified titanium dioxide, a macrogoal 4000.

As Safotsid's analog it is possible to advise to buy separately all active ingredients: azithromycin, секнидазол and флуконазол.

Active ingredients of Safotsid

The medicinal substances which are contained in drug Safotsid concern to different pharmacological groups.

Flukonazol is an antifungal drug. Inhibits synthesis of sterol in a mushroom cell. It is applied to treatment of the opportunistic fungal infections caused by Cryptococcus neoformans, Candida spp., Trichophyton spp., Microsporum spp. Also it is used for treatment of high-contagious mycoses.

Azithromycin belongs to antibiotics of a broad spectrum of activity. Group of macroleads. It is inclined to accumulation in the inflammation center. It is active concerning a set of gram-positive cocci, a number of gram-negative bacteria, some anaerobic activators. Important property – activity concerning Mycoplasma pneumoniae, Chlamydia trachomatis, Ureaplasma urealyticum, Borrelia burgdoferi.

Seknidazol is a bactericidal antimicrobic drug. It is active concerning obligate anaerobic bacteria, activators of a number of protozoan infections.

Indications for appointment Safotsid

Safotsid's use is possible for treatment of the combined infections of an urinogenital path, sexually transmitted: gonorrhoeas, trichomoniasis, clamidiosis, bacterial vaginosis, fungal infections. As well as analogs, Safotsid can be applied also to treatment of the accompanying specific and nonspecific cystitis, uretrit, a vulvovaginitis, tservitsit.

Contraindications

• hypersensitivity to the operating Safotsid's components, and also any drug of their pharmacological groups;
• Safotsid's use is contraindicated along with astemizoly, terfenadiny or other drugs capable to extend QT interval;
• pregnancy;
• feeding by a breast;
• children's age;
• organic diseases of TsNS.

Safotsid's use with care

According to the instruction, Safotsid's use with care is possible at a concomitant use with rifabutiny, tsizapridy or other drugs which are metabolized system P450 cytochrome.

Side effects of Safotsid

• From a liver and a GIT: digestion disturbances, nausea, vomiting, diarrhea, meteorism, abdominal pains, lack of appetite;
• From system of a hemopoiesis: leukopenia;
• From cardiovascular system: extremely seldom there can be disturbances of a heart rhythm;
• Allergic reactions as a small tortoiseshell, anaphylactic reactions;
• From sense bodys: seldom taste disturbances.

According to the instruction and reviews of Safotsida, other side effects meet very seldom: stomatitis, headache, dizziness.

Special instructions

At use at the same time of a flukonazol (Safotsid) and peroral glucose-lowering drugs careful control of a glycemia since it флуконазол can reduce sugar level in blood is necessary.

On Safotsid's instructions, joint reception of a flukonazol and high doses of theophylline can lead to overdose of the last since флуконазол slows down theophylline removal.

At a concomitant use of azithromycin (Safotsid) and warfarin control of a prothrombin time is necessary.

At Safotsid's use and antacids the insufficient positive effect since antiacid drugs slow down azithromycin absorption can be observed.

According to Safotsid's instruction, simultaneous use of azithromycin with dihydroergotamine or ergotamine strengthens their toxic action (it is shown by a vasospasm, a dizesteziya).

Azithromycin (Safotsid) can increase concentration in plasma and, as a result, increases toxicity of Cycloserinum, indirect anticoagulants, a felodipin, Methylprednisolonum, and also drugs which metabolism in an organism proceeds with participation of a microsomal oxidation (carbamazepine, cyclosporine, терфенадин, hexobarbital, valproic acid, ergot alkaloids, Disopyramidum, Phenytoinum, Bromocriptinum, peroral hypoglycemic means, theophylline and other xanthines). It occurs at the expense of inhibition of process of a microsomal oxidation in liver cells azithromycin.

According to the instruction, Safotsid at a concomitant use with ethanol can cause spasms in a stomach, nausea, vomiting, rush of blood to the person, a headache (due to disulfiramopodobny reaction with seknidazoly).

Overdose

There are no data on overdose in the instruction and according to reviews about Safotsida.

Conditions and Safotsid period of storage

To store in the unavailable to children, protected from light, dry place. Temperature of storage is no more than 30 °C.

Period of validity: 3 years.