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Sulfaguanidine

The prices in Internet drugstores:

from 60 rub.

Sulfaguanidine – antibacterial drug, derivative substance of streptocide.Сульгин

Active ingredient of medicine – Sulfaguanidinum.

Release form – tablets of white color. Are a part of one tablet: Sulfaguanidinum (0,5 g) and excipients (примдгель, calcium stearate, potato starch).

Pharmacological effect of Sulfaguanidine

According to the instruction to Sulfaguanidine, drug is effective concerning gram-negative, gram-positive microorganisms and causative agents of intestinal infections. The mechanism of action of Sulfaguanidinum is caused by oppression of a digidropteroatsintetaza that leads to disturbance of formation of tetrahydrofolic acid which is necessary for synthesis of pyrimidines and purines.

Feature of Sulfaguanidine consists in slow absorption of active ingredient from digestive tract at the expense of what drug is late in an organism, providing high concentration of Sulfaguanidinum in intestines. According to reviews Sulfaguanidine is effective medicine for treatment of intestinal infections, similar in action to Ftalazolum.

Indications to Sulfaguanidine use

Drug is appointed at acute, subacute and chronic bacillar (bacterial) dysentery, a coloenteritis, colitis (with a diarrhea), a carriage of sticks of a typhoid, and also by preparation for surgical interventions on a large and small intestine.

Contraindications

Sulfaguanidine is not recommended to be accepted with hypersensitivity to components of drug, a hyperbilirubinemia, a nefrourolitiaza, deficit glyukozo-6-fosfatdegidrogenazy, B12-scarce anemia. According to the instruction Sulfaguanidine is forbidden to be applied to pregnant women, nursing mothers, and also the children who are in chest age.

Side effects of Sulfaguanidine

Active ingredient of Sulfaguanidine can drop out in uric ways in the form of Sulfaguanidinum crystals. In responses to Sulfaguanidine it is said that it is possible to avoid this side effect during treatment by means of a profound diuresis. It is for this purpose recommended to drink not less than 2-3 liters of liquid a day.

Besides, use of Sulfaguanidine can cause the hypovitaminosis connected with oppression of synthesis of vitamins of group B (Riboflavinum, thiamin, niacin) because of suppression of the colibacillus participating in synthesis of these substances. Also as side effects, according to responses to Sulfaguanidine, vomiting, nausea and skin rash are noted.

Interaction with other drugs

According to the instruction to Sulfaguanidine medicine reduces efficiency of peroral contraceptives. Procainum, benzocaine, novocaine, anaesthesin reduce antimicrobic activity of drug. Such antidiabetic medicines as coumarinic anticoagulants, dipheninum increase probability of emergence of side effects of drug, and combined use of Sulfaguanidine with ascorbic acid and hexamethylenetetramine increases acidity of urine, promoting emergence of a crystalluria.Таблетки Сульгин

Route of administration of Sulfaguanidine and dosage

According to responses to Sulfaguanidine, the course of treatment drug at acute intestinal infections proceeds 5-7 days, being followed by reception of medicine on 2-4 tablets 3-4 times a day if other is not appointed by the doctor.

For prevention of complications Sulfaguanidine is recommended to the use in a dose of 0,05 g/kg of body weight each 8 hours in 5 days prior to operation and within a week after surgical intervention.

The maximum single dose for administration of drug (for adults) makes 2 g, daily - 7 g.

Storage of drug is carried out in unavailable to children, the dry place, at a temperature not above 25 degrees Celsius.

The instruction to Sulgin is submitted only in the fact-finding purposes. Before use of medicine consult with the doctor.

The prices in Internet drugstores:

Name of drug

Price

Drugstore

Aveksim's sulfaguanidine таб. 500 mg of n10

60 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Aveksim's sulfaguanidine тбл 500 mg No. 10, Irbit HFZ (Irbit)

65 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC

Aveksim's sulfaguanidine тбл 500 mg No. 20, Irbit HFZ (Irbit)

104 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC
 
 
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