Uregitum

Uregitum – diuretic means.

Pharmacological action of Uregitum

Active active ingredient of drug - Acidum etacrynicum. It quickly renders the expressed diuretic effect, irrespective of acid-base balance. It is effective both at an alkalosis, and at acidosis. A point of application of Uregitum at the level of nephron – the ascending department of a Henle's loop, proximal and distal renal tubules therefore it is carried to group of loopback diuretics. It practically does not influence a renal blood stream and glomerular filtering, excepting cases of reduction of content of liquid because of too big increase in a diuresis. In these cases Uregitum reduces system arterial pressure. The mechanism of its action consists in oppression of active transport of ions of chlorine and sodium in nephron. It is accompanied by the strengthened potassium loss for which completion it is necessary to accept along with diuretic potassium the containing drugs.

In comparison with thiazide analogs of Uregitum the diuretic effect of this drug is expressed several times more as Acidum etacrynicum suppresses the return absorption of sodium in renal tubules much stronger that allows to use drug at the expressed renal failure. The effect of Uregitum dozozavisimy is also directly connected with water delay degree in an organism.

If to accept drug long, removal of ions of chlorine will decrease, and potassium ions and hydrogen on the contrary, can increase.

Uregitum is well soaked up from a digestive tract, bioavailability makes it 100%. Diuretic action begins in half an hour after reception, reaching a maximum in 2 hours, and lasts till 8 o'clock. In a liver conjugation of Uregitum is carried out, it is brought out of an organism with urine and a stake, in partially not changed look.

Release form

Uregitum is issued in tablets on 50 mg.

Indications to use of Uregitum

According to the instruction Uregitum is appointed at hypostases of various origin – renal, cardial, posttraumatic, at portal hypertensia. In case of inefficiency of thiazide or other analogs of Uregitum it is also choice diuretic.

Contraindications

Do not use drug in case of total absence of urine - an anury, at the expressed disturbances of an acid-base and water balance, at a hepatic coma, a lactose intolerance, deficit of enzyme of lactase, during pregnancy and breastfeeding, aged up to 2 years, at intolerance of components. Carefully apply this means at elderly, at primary hyper aldosteronism (disturbances in work of bark of adrenal glands), at diseases of connecting fabric (for example, a system lupus erythematosus).

Application instruction of Uregitum

According to the instruction Uregitum is accepted inside once a day, in the morning after a breakfast, washing down with water. Before an initiation of treatment it is necessary to specify a functional condition of a liver and kidneys. Begin therapy with a dose of 50 mg/days (1 tablet), if necessary gradually raising it to desirable effect, but no more than 200 mg/days (4 tablets). The recommended dose has to be the smallest, causing gradual decrease in body weight by 0,5 – 1 kg/days.

During therapy control of level of a diuresis is required. The maintenance dose averages 25 – 200 mg/days, we will allow the admission of some doses for maintenance of activity of drug. So, Uregitum can be used, passing 1 – 3 day between receptions. Elderly people need a smaller dose for achievement of diuretic effect.

To children 2 years Uregitum are more senior appoint to short term only in the conditions of a hospital 25 mg/days at a nephrotic syndrome or inborn heart diseases.

The combination with Uregitum drug analog from other pharmacological groups of diuretics is allowed.

Side effects

Uregitum most often causes disturbances of water and electrolytic balance (excess loss of potassium, sodium, water, an alkalosis, increase in level of uric acid). Such unpleasant symptoms as abdominal pains, vomiting, diarrhea, a sonitus and a hearing disorder, vision disorders, headaches, changes in the general blood test (decrease in maintenance of thrombocytes, lack of neutrophils), skin rashes, fever are possible.