Актовегин®

General characteristics. Structure:

1 ml of solution contains 40 mg of dry deproteined hemoderivative of blood of calfs as active agent and excipients: sodium chloride, water for injections.

Description. Transparent, from colourless till weak-yellow color solution, almost free from particles.

Pharmacological properties:

Pharmacodynamics. Antigipoksant. АКТОВЕГИН® is hemoderivative which is received by means of dialysis and ultrafiltration (there take place connections with molecular weight less than 5000 дальтон). Positively influences transport and utilization of glucose, stimulates oxygen consumption (that leads to stabilization of plasma membranes of cells at ischemia and to decrease in formation of lactates) possessing, thus, anti-hypoxemic action which begins to be shown the latest in 30 min. after perenteralny introduction and reaches a maximum on average in 3 h (2-6 h).

АКТОВЕГИН® increases concentration of ATP, ADF, phosphocreatinine, and also amino acids – a glutamate, aspartate and GAMK.

Use of the drug AKTOVEGIN® for acceleration of healing of wounds is also based on the data mentioned above, at the same time improve not only morphological, but also biochemical parameters of granulations – concentration of DNA, hemoglobin and hydroxyproline increases.

Pharmacokinetics. By means of pharmacokinetic methods it is impossible to study pharmacokinetic indicators of the drug AKTOVEGIN® as it consists only of physiological components which usually are present at an organism.

So far decrease in pharmacological effect of hemoderivatives at patients with the changed pharmacokinetics is not revealed (for example, a liver or renal failure, the metabolism changes connected with old age and also features of metabolism at newborns).

Indications to use:

- Metabolic and vascular disorders of a brain (acute and chronic forms of disturbances of cerebral circulation, dementia, craniocereberal injury);
- Peripheral (arterial and venous) vascular disorders and their effects (angiopatiya, trophic ulcers);
- Healing of wounds (ulcer of various etiology, trophic disturbances (decubituses), disturbance of processes of healing of wounds);
- Thermal and corrosive burns;
- Radiation damages of skin, mucous membranes, radiation neuropathy.

Route of administration and doses:

Intravenously, intramusculary, vnutriarterialno, and also in the form of infusions.

Instructions for use of ampoules with one point of a break:

a) to arrange an ampoule tip a point up!
b) carefully tapping with a finger and stirring up an ampoule to allow solution to flow down from a tip of an ampoule down.
c) to break off an ampoule tip.

General recommendations about dosing:

Depending on weight of a clinical picture, the initial dose makes 10-20 ml intravenously or vnutriarterialno in days; at further treatment of 5-10 ml intravenously or 5 ml intramusculary.

At introduction in the form of infusions 10-20 ml АКТОВЕГИНа® add to 200-300 ml of the main solution (isotonic solution of sodium chloride or 5% glucose solution). Rate of administering: about 2 ml/min.

Doses depending on indications:

Disturbances of cerebral blood circulation and metabolism: in an initiation of treatment of 10 - 20 ml intravenously daily within two weeks, further 5-10 ml intravenously 3-4 times a week within not less than 2 weeks.

Ischemic stroke: 20-50 ml in 200-300 ml of the main solution intravenously kapelno daily within 1 week, further on 10 - 20 ml intravenously kapelno - 2 weeks.

Angiopatiya: 20-30 ml of drug in 200 ml of the main solution vnutriarterialno or intravenously daily; duration of treatment is about 4 weeks.

The trophic and other badly healing ulcers, burns: 10 ml intravenously or 5 ml intramusculary daily or 3-4 times a week depending on healing process (in addition to topical treatment by the drug Actovegin in dosage forms for topical administration).

Prevention and treatment of radiation damages of integuments and mucous membrane: the average dose makes 5 ml intravenously daily in breaks of radiative effects.

Radiation cystitis: daily 10 ml transuretralno in combination with therapy by antibiotics.

Features of use:

In case of an intramuscular route of administration enter slowly no more than 5 ml.
Because of possibility of anaphylactic reaction it is recommended to carry out a trial injection (2 ml intramusculary).
It is necessary to meet asepsis conditions as Actovegin for injections does not contain preservatives.
Solution for injections has slightly yellowish shade. Intensity of coloring can vary from one party to another depending on features of the used starting materials, however it has not an adverse effect on activity of drug or its portability.
After opening of an ampoule solution it is impossible to store and use the stored solution.

Side effects:

Allergic reactions (for example, urticaria, hypostases, medicinal fever). In such cases treatment АКТОВЕГИНом® needs to be stopped. If necessary carry out standard therapy of allergic reactions (antihistamines and/or corticosteroids).

Contraindications:

Hypersensitivity to the drug AKTOVEGIN® or similar drugs.

With care:

Heart failure of the II-III degree, fluid lungs, oliguria, anury, overhydratation, diabetes mellitus, hyperglycemia; pregnancy, lactation period.

Use at pregnancy and a lactation is allowed.

Storage conditions:

Period of storage - 2 years. Not to use after a period of validity. Storage conditions. At a temperature of 18 - 25 °C in the place protected from light. To store in the place, unavailable to children!

Issue conditions:

According to the recipe

Packaging:

Solution for injections of 40 mg/ml. Ampoules on 2, 5 and 10 ml. On 5, 10 or 25 ampoules with the application instruction place in a cardboard box.