Actovegin
Producer: Nycomed Austria GmbH (Nikomed Austria Gmbh) Austria
Code of automatic telephone exchange: B06AB
Pharm group: a href="javascript:if(confirm(%27medicalmeds.eu/preparats_title.php?name=-1&mnn=-1&atc=8 \n\nThis file was not retrieved by Teleport Pro, because it is linked too far away from its Starting Address. If you increase the in-domain depth setting for the Starting Address, this file will be queued for retrieval. \n\nDo you want to open it from the server?%27))window.location=%27medicalmeds.eu/preparats_title.php?name=-1&mnn=-1&atc=8%27" tppabs="medicalmeds.eu/preparats_title.php?name=-1&mnn=-1&atc=8">Other hematologic drugs
Release form: Firm dosage forms. Tablets.
General characteristics. Structure:
1 tablet coated contains:
Kernel: active agent: blood components: deproteined hemoderivative of blood of calfs – 200 mg, magnesium stearate, povidone (To 90), talc, cellulose.
Cover: acacias gum, wax mountain glycolic, gipromelloza phthalate, diethyl phthalate, dye quinolinic yellow aluminum a varnish, a macrogoal (6000), povidone (To 30), sucrose, talc, titanium dioxide.
Description: chartreuse brilliant round coated tablets.
Pharmacological properties:
Pharmacodynamics. Antigipoksant. АКТОВЕГИН® is hemoderivative which is received by means of dialysis and ultrafiltration (there take place connections with molecular weight less than 5000 дальтон). Positively influences transport and utilization of glucose, stimulates oxygen consumption (that leads to stabilization of plasma membranes of cells at ischemia and to decrease in formation of lactates) possessing, thus, anti-hypoxemic action which begins to be shown the latest in 30 min. after peroral introduction and reaches a maximum on average in 3 h (2-6 h).
АКТОВЕГИН® increases concentration of adenosinetriphosphate, adenosinediphosphate, phosphocreatinine, and also amino acids – a glutamate, aspartate and piperidic acid.
Pharmacokinetics. By means of pharmacokinetic methods it is impossible to study pharmacokinetic indicators of the drug AKTOVEGIN® as it consists only of physiological components which usually are present at an organism.
So far decrease in pharmacological effect of hemoderivatives at patients with the changed pharmacokinetics is not revealed (for example, a liver or renal failure, the metabolism changes connected with old age and also features of metabolism at newborns).
Indications to use:
• Complex therapy of metabolic and vascular disorders of a brain (various forms of insufficiency of cerebral circulation, dementia, craniocereberal injury);
• Peripheral (arterial and venous) vascular disorders and their effects (angiopatiya, trophic ulcers).
Route of administration and doses:
Inside, on 1-2 tablet 3 times a day, without chewing, before food, washing down with a small amount of liquid. Duration of treatment has to make from 4 to 6 weeks.
Side effects:
Allergic reactions (for example, urticaria, hypostases, medicinal fever). In such cases treatment АКТОВЕГИНом® needs to be stopped. If necessary carry out standard therapy of allergic reactions (antihistamines and/or corticosteroids).
Interaction with other medicines:
Now it is unknown.
Contraindications:
Hypersensitivity to the drug AKTOVEGIN® or similar drugs.
With care:
Heart failure of II and III degrees, fluid lungs, oliguria, anury, overhydratation; pregnancy, lactation period.
Use at pregnancy and a lactation is allowed.
Storage conditions:
Period of validity 3 years. Not to use after a period of validity. At a temperature not above 25 °C in the place protected from light. To store in the place unavailable to children!
Issue conditions:
According to the recipe
Packaging:
Tablets coated 200 mg, On 50 tablets in bottles of dark glass (type III, Evr.farm.) with the screw mouth and the screwing-up cover providing control of the first opening. 1 bottle with the application instruction is placed in a cardboard pack. In case of packaging and/or packaging of drug on CJSC Pharmfirma Soteks: On 10, 30, or 50 tablets in bottles of brown glass of the hydrolytic class ISO 720-HGA 3 with a screw mouth corked by caps aluminum on TU 9299-158-00008064-98 with control of the first opening, with sealing laying. 1 bottle with the application instruction is placed in a pack from a cardboard.