Actovegin solution

General characteristics. Structure:

50 ml of solution contain:
active agent: blood components – deproteined hemoderivative of blood of calfs:
- dosage of 4 mg/ml: 25 ml (соотв. 1 g of dry weight),
- dosage of 8 mg/ml: 50 ml (соотв. 2 g of dry weight); excipients: sodium chloride, water for injections.

Description: transparent, from colourless till weak-yellow color solution.

Pharmacological properties:

Pharmacodynamics. Antigipoksant. АКТОВЕГИН® is hemoderivative which is received by means of dialysis and ultrafiltration (there take place connections with molecular weight less than 5000 дальтон). Positively influences transport and utilization of glucose, stimulates oxygen consumption (that leads to stabilization of plasma membranes of cells at ischemia and to decrease in formation of lactates) possessing, thus, anti-hypoxemic action which begins to be shown the latest in 30 min. after parenteral administration and reaches a maximum on average in 3 h (2-6 h).
АКТОВЕГИН® increases concentration of adenosinetriphosphate, adenosinediphosphate, phosphocreatinine, and also amino acids – a glutamate, aspartate and piperidic acid.

Pharmacokinetics. By means of pharmacokinetic methods it is impossible to study pharmacokinetic indicators of the drug AKTOVEGIN® as it consists only of physiological components which usually is present at an organism.
So far decrease in pharmacological effect of hemoderivatives at patients with the changed pharmacokinetics is not revealed (for example, a liver or renal failure, the metabolism changes connected with old age and also features of metabolism at newborns).

Indications to use:

• Metabolic and vascular disorders of a brain (including ischemic stroke, craniocereberal injury).
• Peripheral (arterial and venous) vascular disorders and their effects (arterial angiopatiya, trophic ulcers).
• Healing of wounds (ulcers of various etiology, burns, trophic disturbances (decubituses), disturbance of processes of healing of wounds).
• Prevention and treatment of radiation injuries of skin and mucous membranes at radiation therapy.

Route of administration and doses:

Intravenously kapelno or intra arterial struyno. On 250-500 ml a day. Speed of infusion has to make about 2 ml/min. Duration of a course of treatment is 10-20 infusions. Due to potentiality of development of anaphylactic reactions, it is recommended to carry out the test prior to infusion.
Metabolic and vascular disorders of a brain: at the beginning – 250-500 ml/days intravenously an extent of 2 weeks, further – on 250 ml intravenously several times a week.
Peripheral vascular disorders and their effects: 250 ml vnutriarterialno or intravenously, daily or several times a week.
Healing of wounds: 250 ml intravenously, daily or several times a week depending on healing speed. Sharing with АКТОВЕГИНом© in the form of medicines for topical administration is possible.
Prevention and treatment of radiation injuries of skin and mucous membranes: on average 250 ml intravenously a day before the beginning and daily during radiation therapy, and also within 2 weeks after its termination.

Features of use:

At repeated introductions it is necessary to control water and electrolytic balance of a blood plasma.
Infusion solution has slightly yellowish shade. Intensity of coloring can vary from one party to another depending on features of the used starting materials, however it has not an adverse effect on activity of drug or its portability.
Do not use the opaque solution or solution containing particles.
After opening of a bottle, solution cannot be stored.

Side effects:

Allergic reactions (skin rash, dermahemia, hyperthermia) up to an acute anaphylaxis.

Interaction with other medicines:

Now it is unknown.
However, in order to avoid possible pharmaceutical incompatibility, it is not recommended to add other medicines to AKTOVEGINA® infusion solution.

Contraindications:

Hypersensitivity to the drug AKTOVEGIN® or similar drugs, dekompensirovanny heart failure, a fluid lungs, an oliguria, an anury, a liquid delay in an organism. With care: hyperchloremia, hypernatremia.

Use at pregnancy and a lactation: use of drug did not cause negative impact on mother or a fruit in pregnant women. However at use for pregnant women it is necessary to consider potential risk for a fruit.

Storage conditions:

Period of validity of 5 years. Not to use after a period of validity. At a temperature not above 25 °C in the place protected from light. To store in the place unavailable to children!

Issue conditions:

According to the recipe

Packaging:

Solution for infusions [in solution of sodium of chloride of 0,9%] 4 mg/ml, 8 mg/ml.
On 250 ml in the bottle for infusions from colourless glass (Evr.farm.dtsh II) corked by a stopper and an aluminum cap under a running in, from above closed by the cover providing control of the first opening.
1 bottle together with the application instruction is placed in a cardboard pack. On a pack paste transparent protective stickers of a round form with holographic texts and control of the first opening.