Heparin

General characteristics. Structure:

Active ingredient: 100 PIECES of heparin, 40 mg of anaesthesin.

Pharmacological properties:

Pharmacodynamics. Heparin ointment when drawing has antiinflammatory effect on skin, interferes with formation of blood clots and possesses local analgeziruyushchy action.

Pharmacokinetics. Heparin after absorption biotransformirutsya in a liver (partially by enzyme a hepatic haparinase) and in reticuloendothelial system.

Indications to use:

Unguentum Heparini is applied at thrombophlebitis of extremities (preferential superficial) and fibrinferment of hemorrhoidal veins.

Route of administration and doses:

At thrombophlebitis of extremities heparin (from calculation for 0,5 — 1 g on the site with a diameter of 3 — 5 cm) grease with a thin layer of ointment area of defeat and carefully rub ointment in skin. At fibrinferment of hemorrhoidal veins ointment is applied on byazevy or linen laying which is imposed directly on the restrained nodes and fixed a bandage.

With the same purpose it is possible to use the tampon impregnated with Unguentum Heparini which is entered into an anus. Ointment is applied by 2 — 3 times a day daily before disappearance of the inflammatory phenomena, on average from 3 to 14 days.

Features of use:

Use at pregnancy is possible only according to indications, under medical control. Use at a lactation is possible — according to indications.

Side effects:

Local allergic reactions are in some cases possible.

At use of drug in the recommended doses of toxic effects it is not revealed.

Interaction with other medicines:

Anticoagulative effect of heparin amplifies at simultaneous use of anticoagulants, antiagregant and NPVS. Ergot alkaloids, thyroxine, tetracycline, antihistamines and nicotine reduce effect of heparin.

Contraindications:

Use of ointment is contraindicated at ulcer and necrotic processes in a thrombophlebitis zone, and also at the lowered coagulability of blood.

Overdose:

Symptoms: at prolonged use on big surfaces hemorrhagic complications are possible.

Treatment: drug withdrawal. If necessary apply the antagonist of heparin — protamin sulfate (1% solution).

Issue conditions:

According to the recipe

Packaging:

Ointment for external use 100ME/g on 25 g in aluminum tubas or banks.