Gemostabil

General characteristics. Structure:

Active ingredients: 10 g of a dextran 40000, 7,5 g of sodium of chloride.

Excipients: water for injections.

Pharmacological properties:

Pharmacodynamics. Gemostabil — the complex drug representing hypertonic salt solution. Under the influence of a hypertensive component (high concentration of sodium chloride, osmolarity of 2567 мОсм) water, preferential from intersticial space quickly moves to a vascular bed, increasing the volume of intravascular liquid. Action of hypertonic saline solution is short in connection with elimination of ions of sodium and chlorine from vessels. The dextran 40 within 3-4 hours holds liquid in a blood channel, supports the volume of the circulating blood, having, thus, hemodynamic effect. The maximum influence on volume of the circulating blood is a cooperative effect of hypertonic salt solution and a dextran 40. Drug possesses volemichesky action within 150-200% of the entered volume which remains within 30-60 minutes. Infusion of 250 ml of Gemostabil gives increase in intravascular volume of liquid up to 1000 ml within 5 minutes.

Pharmacokinetics. The combination of sodium chloride and a dextran 40 does not change pharmacokinetic properties of each component. Content of sodium in a blood plasma after Gemostabil's introduction increases to 9-12 mmol/l, being returned to normal values less than in 4 hours. The elimination half-life "the Dextran 40" — 3-4 hours, is allocated with kidneys with urine in an invariable look.

Indications to use:

It is intended for initial completion of deficit of volume of the circulating blood for prevention and treatment of a hypovolemia and shock with hypotension at acute blood losses, injuries, wounds, surgical interventions, burns, infectious diseases.

Route of administration and doses:

Gemostabil appoint in the form of intravenous infusions in peripheral or central veins. Introduction is carried out once, struyno in a dose of 250 ml, within 2-4 min. 250 ml of drug Gemostabil is an optimum dose.

Increase in volume of the circulating blood and stabilization of a hemodynamics reduces risk of development of irreversible pathological reactions of an organism in response to an acute hypovolemia.

After drug transfusion Gemostabil infusional therapy is continued with use of crystalloidal and colloidal solutions, blood preparations in necessary volumes. Preferably after Gemostabil's introduction to apply isotonic solutions.

Features of use:

With care appoint drug at heavy disturbances of blood coagulation (except life-threatening states), dehydrations. As Gemostabil considerably increases within a short period of time the volume of intravascular liquid, it is necessary to pay attention to the patient with heart failure. At patients with a diabetes mellitus at the expressed hyperglycemia and hyper osmolarity, Gemostabil it is necessary to apply with care.

In the course of treatment it is necessary to control ionic composition of blood serum, balance of liquid and function of kidneys.

At administration of drug in peripheral veins emergence of burning sensation and morbidity in an extremity on the course of a vein to which drug infusion is carried out is possible.

Side effects:

Individuals can have reactions of intolerance, and in exceptional cases allergic reactions of various type up to the anaphylactic/anaphylactoid phenomena. In this case it is necessary to stop immediately administration of drug and to hold necessary urgent events.

Interaction with other medicines:

Interaction with other medicines and drugs is not revealed.

Contraindications:

The known hypersensitivity / allergy to drug or its components, late durations of gestation and a lactation, heavy cardiopulmonary insufficiency; renal failure, overhydratation. Children's age.

Overdose:

Symptoms of overdose it is not established.

Storage conditions:

In the dry place at a temperature from 10 to 30 °C. Freezing when transporting is allowed. To store in the places unavailable to children. A period of validity - 2 years. Not to use after the date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Solution for infusions on 100, 250, 600 ml in polymeric containers for infusion solutions of single use. Each container is packed into a secondary package of the put application instruction.