Simepar

General characteristics. Structure:

Gelatinous solid capsules, the size No. 3, with the case and a lid of brown color, with a text of "Simepar Mepha"; contents of capsules - powder of light brown color.

Active ingredient: extract of a thistle of spotty  90-133 mg,
     what corresponds to the maintenance of Silymarinum                        of 70 mg
thiamin hydrochloride (Vit. B1)                                                 4 mg
Riboflavinum (Vit. B2)                                                                4 mg
calcium pantothenate (Vit. B5)                                                    8 mg
pyridoxine hydrochloride (Vit. B6)                                          4 mg
cyanocobalamine (Vit. B12)                                                   1.2 mkg
niacinamide (Vit. PP)                                                             12 mg

Excipients: lactose 80, talc, lactose 200.

Structure of a cover: gelatin, titanium dioxide (E171), ferrous oxide red (E172), ferrous oxide black (E172).

Pharmacological properties:

Pharmacological action
The combined hepatoprotective drug. The complex of vitamins and extract of fruits of a thistle spotty is a part of drug. Extract contains Silymarinum - group of flavonoidny connections of fenilkhromanovy structure which includes isomers: силибидин, силиданин and силикристин.

Silymarinum protects hepatocytes from influence of hepatotoxic agents, prevents destruction of cellular membranes. Improves cellular metabolism. Has hepatoprotective effect at acute and chronic intoxications and antioxidant action due to binding of free radicals in liver tissue, has membrane stabilizing activity, stimulates protein synthesis, promotes regeneration of hepatocytes.

The vitamins which are a part of drug perform function of coenzymes in various reactions of carbohydrate and protein metabolism and accelerate recovery of the damaged liver cells. And also, compensate a vitamin deficiency in an organism.

Pharmacokinetics. After intake Silymarinum is generally allocated with bile, passing intra hepatic system. Silibininum is generally removed by kidneys while metabolites, in particular, sulfate and a glucuronide are also removed with bile. Silibininum is removed within 24 hours, total quantity of Silibininum which is allocated with bile makes 20-40%. Only 3-7% are removed by kidneys.

Indications to use:

— toxic and inflammatory damages of a liver (chronic hepatitises, including steatogepatita, fatty dystrophy of a liver) as a part of complex therapy;

— prevention of toxic damages of a liver (owing to influence of alcohol or medicines).

Route of administration and doses:

Adult

Capsules accept inside, after food, without chewing, with a small amount of water.

The recommended medical dose of drug makes on 1 капс. 3

At prolonged use and for prevention of toxic damages of a liver the dose of drug can be reduced to 1 капс. 2

Course of treatment - 1-3 months.

Features of use:

Drug should not be accepted to patients with a hereditary lactose intolerance, deficit of enzyme of lapp-lactase, malabsorption of a glucose/galactose since as a part of drug lactose contains.

Influence on ability to driving of motor transport and to control of mechanisms

Data on a negative impact of Simepar on ability to driving of motor transport and work with mechanisms are not known.

Side effects:

From the alimentary system: dyspepsia, diarrhea.

Allergic reactions: skin rash, itch.

Interaction with other medicines:

Data on medicinal interaction of the drug Simepar™ are not available.

Contraindications:

— children's and teenage age up to 18 years (there are no data on efficiency and safety);

— hypersensitivity to any of drug components.

 

Use of the drug SIMEPAR™ at pregnancy and feeding by a breast

Data on influence of drug on reproductive function are unknown. At pregnancy and in the period of a lactation drug can be accepted under observation of the doctor in cases when the expected advantage of therapy for mother exceeds potential risk for a fruit or the child.

Overdose:

Cases of overdose were not observed.

Treatment: at overdose the gastric lavage and symptomatic therapy is shown.

Storage conditions:

Drug should be stored in the place, dry, unavailable to children, at a temperature not above 25 °C. A period of validity - 5 years.

Issue conditions:

According to the recipe

Packaging:

10 - planimetric strip packagings (4) - packs cardboard.