Резалют® Missile defense

General characteristics. Structure:

Active agent: Lipoid PPL of 600 - 600 mg consisting from: phospholipids polyunsaturated of soy lecithin - 300,0 mg, a glitserola mono / диалконат (C14-C18) - 120,0 mg, triglycerides of an average chain - 40,5 mg, oil soy cleared - 138,5 mg, and - tocopherol - 1,0 mg;
excipient: oil soy cleared;
capsule cover: gelatin, глицерол 85%.

Description. Transparent colourless gelatin capsules of oblong shape. Contents of capsules: viscous liquid from golden-yellow till yellowy-brown color.

Pharmacological properties:

Pharmacodynamics. Extract of soy phospholipids consists of phosphatidylsincaline and phosphoglycerides (on average, for 76%); at the same time from fatty acids linolic acid prevails. Hepatoprotective effect of drug is caused by acceleration of process of regeneration of cells of a liver and stabilization of cellular membranes, braking of process of oxidation of lipids and suppression of synthesis of collagen in a liver. Drug normalizes lipidic exchange, reducing cholesterol level by increase in formation of its ethers and linolic acid.

Pharmacokinetics. Researches of pharmacokinetics of phosphatidylsincaline showed that it breaks up in intestines to lizo-phosphatidylsincaline and is soaked up, preferential, in the same form. In a gut wall partially there is its resynthesis to phospholipid which then on absorbent vessels gets to a circulator bed, a part of lizo-phosphatidylsincaline breaks up in a liver to fatty acids, sincaline and glycerin-3-phosphate. In plasma phosphatidylsincaline and other phosphoglycerides strongly contact lipoproteins and/or albumine. The most part of the entered soy phospholipids with high content in them (Z-sn-fosfatidil) - sincaline combines in the form of metabolites, with own phospholipids of an organism within several hours. Their removal corresponds to excretion of own phospholipids of an organism or their metabolites.

Indications to use:

• fatty degeneration of a liver of various etiology; chronic hepatitises; toxic damages of a liver, cirrhosis;
• a hypercholesterolemia, at inefficiency of a diet and other non-drug measures (physical activity and actions for decrease in body weight).

Route of administration and doses:

Drug is intended for intake.
If there are no other instructions, it is necessary to accept 2 Missile defense Rezalyuta® capsules 3 times a day before food, without chewing and washing down with enough liquid. Duration of a course of treatment depends on the course of a disease.

Features of use:

One Missile defense Rezalyuta® capsule contains less than 0,1 GU (grain unit). Influence of drug on ability to driving of motor transport and to control of mechanisms is not known.

Side effects:

From digestive tract: the discomfort in epigastric area, diarrhea can sometimes take place.
Allergic reactions: in rare instances skin rash, small tortoiseshell.
From system of a hemopoiesis: extremely seldom - petekhialny rashes, bleedings at women during the intermenstrual period.

Interaction with other medicines:

Incompatibility cases are not known so far. However it is impossible to exclude interaction of Rezalyuta® of Missile defense with coumarinic anticoagulants (for example, fenprokumony, warfarin). In case of inevitability of the corresponding combination therapy there can be a need for medicine dose adjustment.

Contraindications:

• hypersensitivity to phospholipids, a peanut, soy and other components of drug;
• anti-phospholipidic syndrome.

With care: children's age up to 12 years.

Use at pregnancy and a lactation
Data on safety of use of drug at pregnancy are absent. Therefore it is necessary to apply Rezalyut® of Missile defense only if the estimated advantage for mother exceeds possible risk for a fruit.
There are no data on penetration of Rezalyuta® of Missile defense into breast milk therefore in need of use of Rezalyuta® of Missile defense in the period of a lactation breastfeeding for administration of drug should be stopped.

Overdose:

Messages on overdose and intoxication drug did not arrive so far.

Storage conditions:

At a temperature not above 25 °C. To store medicine in the place, unavailable to children! Period of validity 2 years. Not to apply after the expiry date specified on packaging.

Issue conditions:

Without recipe

Packaging:

Capsules of 300 mg. On 10 capsules in blister strip packagings (blisters) [aluminum PVC / PVDH / foil]. On 1, 3 or 5 blisters together with the application instruction in a cardboard pack.