Siliborum 35, the tab. on 35 mg No. 25

General characteristics. Structure:

Main physical and chemical properties: tablets, coated, from orange till brownish-orange color, with a biconvex surface. On a surface of tablets the mramornost and impregnations is allowed. On cross section two layers are visible; structure: 1 tablet contains Silymarinum (in terms of 100% the maintenance of flavolignan [Silymarinum]) – 35 mg; excipients: potato starch, sodium starch glikolit, calcium stearate, lactoses monohydrate, a gipromeloz (gidroksipropilmetiltsellyuloz), titanium dioxide, dye yellow "Sunset" E 110.

Pharmacological properties:

Siliborum contains the sum of flavonoids (Silibininum, силикристин, силидианин) from fruits of a thistle spotty – Silybum marianum (L.).
Pharmacodynamics. Hepatoprotective means which mechanism of action is caused by antioxidant and membrane stabilizing activity. Improves a metabolism in hepatocytes: normalizes exchange of phospholipids, stimulates synthesis of structural and functional proteins, RNA and glycogen. Interferes with penetration of gepatotoksichny substances into cells of a liver and accelerates processes of regeneration of hepatocytes.

Pharmacokinetics. It is slowly soaked up from digestive tract (the semi-absorption period – 2,2 h), metabolized in a liver by conjugation. To 40% of Silymarinum which is allocated with bile it reabsorbirutsya again and comes to a cycle of enterogepatichesky circulation. It is removed preferential with bile in the form of glucuronides and sulfates, to a lesser extent – with urine. An elimination half-life – 6 h. In an organism does not collect.

Indications to use:

Chronic hepatitises of various etiology, cirrhosis (as a part of complex therapy), states after postponed acute infectious and toxic hepatitises, liver steatoses. As prophylactic at long professional intoxications and long consumption of the medicines having hepatotoxic effect.

Route of administration and doses:

Accept inside to food, without chewing, washing down with a small amount of water. To adults and children 12 years are aged more senior appoint 2–3 tablets 3 times a day. Patients with severe forms of a disease if necessary can increase a daily dose to 4 tablets 2–3 times a day. To children aged from 4 up to 6 years appoint on 1 tablet 2 times a day, from 6 to 12 years – on 1 tablet 3 times a day. A course of treatment – 1 month; if necessary it is possible to increase up to 3 months and more. The course of treatment can be repeated in 1–2 months. As prophylactic is accepted on 2–3 tablets in days from 1 to 3 months.

Features of use:

During pregnancy and feeding by a breast drug can be used only provided that the advantage of treatment of mother is more, than risk for the child. At use of drug the increase in a diuresis caused by insignificant diuretic effect, characteristic of flavonoids, can be observed.

Side effects:

The dispeptic phenomena and allergic reactions in the form of skin rashes and an itch are seldom possible. In such cases the dose is reduced or drug is cancelled. At long courses of use of drug strengthening of the existing disturbances of vestibular function can be observed.

Interaction with other medicines:

Siliborum can be applied in a complex with other medicines which are usually applied at diseases of a liver and biliary tract.

Contraindications:

Hypersensitivity to drug components. Children under 4 years.

Overdose:

So far cases of overdose of Siliborum are not described. At overdose of drug it is necessary to cause vomiting, to wash out a stomach, to appoint absorbent carbon, to carry out symptomatic therapy.

Storage conditions:

To store in the dry, protected from light place at a temperature from 8ºС to 30ºС. To store in the place, unavailable to children.
Period of validity – 2 years.

Issue conditions:

Without recipe

Packaging:

Tablets No. 25, No. 10х3, No. 10х8 in blister strip packagings in packs; No. 25 in blister strip packagings without investment in a pack.