Cytochrome C
General characteristics. Structure:
Active ingredient: 10 mg of cytochrome C.
Excipient: 0,9% of sodium of chloride.
Metabolic means, has anti-hypoxemic, cytoprotective effect, stimulates processes of regeneration in fabrics.
Pharmacological properties:
Pharmacodynamics. The fermental drug received by way of extraction from tissues of hearts of cattle. At the cellular level is the catalyst of tissue respiration, normalizes exchange processes and utilization of oxygen in fabrics, reduces a hypoxia of fabrics at various morbid conditions.
Pharmacokinetics. At intramuscular introduction by Tsitokhr With is defined in a system blood-groove in 15 min. and it is quickly distributed. At intravenous the sposobevvedeniya effect of drug comes within the several first minutes.
In 24 hours Tsitokhr With found in a system blood-groove in trace quantities.
The maximum concentration of drug in tissues of heart and liver is reached in 30 min., in tissues of a brain, lungs and kidneys — in 1 hour.
Cytochrome C in fabrics is characterized by semi-removal time about 5,5 hours.
Absolute bioavailability is maximum in a blood plasma, a brain, a liver, heart, lungs and kidneys (in decreasing order).
Indications to use:
Apply in complex therapy as the means improving tissue respiration at the states which are followed by disturbance of oxidation-reduction processes in an organism: asphyxia of newborns; severe injuries; before an operative measure (for the purpose of the prevention of shock); at patients with a chronic obstructive pulmonary disease and heart failure; at the viral hepatitis complicated by a hepatic coma; at poisoning with somnolent drugs and carbon monoxide.
Route of administration and doses:
Drug is used intravenously and intramusculary. Before use of Tsitokhroma-S it is necessary to dissolve contents of a bottle in 4 ml of water for injections and to define individual sensitivity to it. For this purpose vnutrikozhno enter 0,1 ml of drug (0,25 mg). If at the same time within 30 minutes there does not come reaction (face reddening, a skin itch, a small tortoiseshell), then it is possible to start treatment by drug. Before purpose of a repeated course surely repeat a bioassey.
The drug is administered intravenously slowly or intramusculary in number of 10-20 mg by 1-2 times a day. The course of treatment makes 10-14 days.
At heart failure drug is dissolved in 200 ml of isotonic solution of sodium chloride or 5% of solution of glucose and entered intravenously kapelno (30-40 drops a minute) within 6-8 hours. The daily dose makes 30-80 mg.
In the postoperative period (operation for the inborn and acquired heart diseases) the drug is administered intravenously by 2 times a day on 10 mg on an injection. B a case of serious condition (an injury, shock, a hepatic coma, poisoning with somnolent drugs and carbon monoxide), appoint drug in number of 50-100 mg. At asphyxia of newborns the drug is administered in an umbilical vein for the first two minutes after the birth in a dose 10 mg.
At bronchial asthma drug is appointed intramusculary by 2 times a day in a dose of 5-10 mg to an injection. The course of treatment proceeds from 14 to 25 days depending on weight of a hypoxia.
Side effects:
At bystry administration of drug there can be a fever with temperature increase, allergic reactions. At prolonged use are possible: change of a picture of peripheral blood, indicators of coagulant system of blood, function of a liver.
Interaction with other medicines:
It is not described.
Contraindications:
Hypersensitivity to drug, pregnancy, the lactation period.
Storage conditions:
In the dry, protected from light place at a temperature not above +20 degrees Celsius. To protect from children!
Issue conditions:
According to the recipe
Packaging:
Lyophilisate for preparation of solution for intravenous and intramuscular administration in the bottles with a capacity of 5 ml containing 10 mg of drug. On 5 bottles in the blister from PVC and aluminum, on 1 or 2 blisters in a cardboard box.
