Deficit of a protein of S
Contents:
- Description
- Symptoms of Deficit of a protein of S
- Reasons of Deficit of a protein of S
- Treatment of Deficit of a protein of S
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Description:
Protein of C - the vitamin-to-dependent protein synthesized in a liver which contacts thrombomodulin (protein on endothelial cells) and turns thrombin into active protease (fig. 60.5). Interacting with S protein, the activated protein With destroys a factor of Va and a factor of VIIIa, stopping formation of fibrin.
Symptoms of Deficit of a protein of S:
Deficit of a protein of S is shown by recurrent venous fibrinferments and TELA and autosomal is usually inherited it is prepotent. Structural anomalies of this protein are found in some patients with fibrinferments.
Level of a protein of S is not so rigidly connected with bent to fibrinferments as antithrombin III level.
At last, a part of a protein of S contacts the C4b-connecting protein, losing functional activity. Perhaps, it is necessary to measure more precisely level as the general, and a free protein of S or at the same time to determine the level of the C4b-connecting protein.
Reasons of Deficit of a protein of S:
The mode of inheritance is autosomal and dominant.
Treatment of Deficit of a protein of S:
Patients with heterozygous deficit of a protein of S at acute fibrinferments have to receive heparin, and later - to pass to indirect anticoagulants. At the same time, however, the following complexity is possible: indirect anticoagulants can reduce level not only a factor of II, a factor of VII, a factor of IX and a factor of X, but also a protein With and S protein that will nullify their antitrombotichesky action.