Serum antibotulinic type E the horse cleared concentrated

General characteristics. Structure:

Active ingredient: 10 000 ME of serum antibotulinic type E.

Pharmacological properties:

Pharmacodynamics. Serum antibotulinic type E represents protein fraction of blood serum of horses, immunizirovanny botulinic anatoxin or toxin like E, containing specific immunoglobulins.

Drug contains the antitoxins neutralizing botulinum toxins like E.

Indications to use:

— treatment and prevention of botulism.

Route of administration and doses:

Serum antibotulinic is applied with the medical and preventive purpose.

With the medical purpose serum is entered into the earliest terms from the moment of emergence of the first symptoms of botulism. Before administration of serum it is necessary to take blood of 10 ml from the patient, urine, washing waters of a stomach (emetic masses) for a research on botulinum toxin and the causative agent of botulism. Also the foodstuff which caused a disease is sent to a research.

For treatment of the diseases caused by unknown type of toxin (activator) of botulism use mix of monovalent serums (type A, B and E). At the known type of toxin (activator) use monovalent serum of the corresponding type.

Regardless of degree of manifestation of clinical symptomatology intravenously kapelno enter one medical dose of drug which is parted in 200 ml of sodium of chloride of the solution for injections 0.9% which is warmed up before introduction in warm water up to the temperature (37±1) of °C. Rate of administering of 60-90 drops in a minute. In exceptional cases, at impossibility of implementation of drop infusion, slow jet introduction of a medical dose of serum by the syringe without preliminary cultivation is allowed. In order to avoid possible allergic reactions prior to intravenous injection, serum to the patient struyno enter 60-90 mg of Prednisolonum.

Serum is entered once.

With the preventive purpose serum is entered to the people using products which caused a disease of botulism along with the patient. Enter a half of a medical dose (a half of contents of an ampoule) of serum of the same type, as type of the toxin which caused a disease. If the type of toxin is not established, enter on a half of a medical dose of all types of monovalent serums. The drug is administered intramusculary

Before use the ampoule with drug is carefully examined. Drug in ampoules with the broken integrity, lack of marking is not suitable for use, at change of physical properties, drug (discoloration, existence of not breaking flakes), at the expired period of validity, the wrong storage. Before introduction the ampoule with serum is heated, keeping in water at a temperature (37±1) of °C of 5 min.

Opening of ampoules with serum, the procedure of administration of drug and storage of the opened ampoule (no more than an hour) is carried out at strict observance of rules, asepsises and antiseptic agents.

Administration of serum is carried out under observation of the doctor.

Before administration of serum of sensitivity, antibotulinic for identification, to a foreign protein without fail carry out an intracutaneous test with serum horse cleared divorced 1:100 which is complete with drug.

Ampoules with serum horse cleared divorced 1:100 are marked red, and with serum antibotulinic - blue or black color.

Serum horse cleared divorced 1:100 enter in a dose 0.1 ml vnutrikozhno into the flexion surface of a forearm.

Test is considered negative if in 20 minutes reddening on site of introduction less than 1 cm swelled or. Test is considered positive if hypostasis or reddening reach 1 cm and more.

At a negative intracutaneous test subcutaneously enter 0.1 ml of serum antibotulinic. In the absence of reaction to the last in 30 min. enter intravenously or intramusculary all appointed serum dose.

At a positive intracutaneous test with serum horse cleared divorced 1:100 or in cases of emergence of allergic reactions, on a subcutaneous injection of not divorced serum, serum antibotulinic enter only in the medical purposes under observation of the doctor and with special precautions: in the beginning, after intramuscular introduction of 60 mg of Prednisolonum and antihistaminic drugs, enter subcutaneously serum horse cleared divorced 1:100, intended for an intracutaneous test, at an interval of 20 min. in a dose of 0.5 ml, 2.0 ml and 5.0 ml. In the absence of reaction to these doses subcutaneously enter 0.1 ml of serum antibotulinic. In the absence of reactions in 30 min. intramusculary enter all dose of serum.

In case of positive reaction to one of the above-stated doses, to the patient intravenously struyno enter 180-240 mg of Prednisolonum and, 5-10 min. later, intramusculary all medical dose of serum.

Features of use:

Use at pregnancy and feeding by a breast. Use of drug is allowed to lifelong indications taking into account possible advantage for mother and risk for a fruit or the child.

Special instructions. Precautionary measures at use. Considering possibility of an acute anaphylaxis, it is necessary to provide medical observation for privitsh within 30 min. after the end of administration of drug.

Rooms in which administration of serum antibotulinic is carried out have to be provided with means of antishock therapy, first of all adrenaline (Epinephrinum).

Administration of serums (antibotulinic й divorced) has to be registered in the history of a disease with the obligatory indication of a dose, way and time of introduction, reaction of the patient, number of a series, the name of the enterprise which made drug.

Influence on ability to driving of motor transport and to control of mechanisms. Data are absent.

Side effects:

Administration of serum antibotulinic can be followed by development of allergic reactions of immediate type, including an acute anaphylaxis, and also a serum disease.

Interaction with other medicines:

It is not revealed.

Contraindications:

Contraindications to use of specific means of the emergency prevention of a botulinizm:

— existence in the anamnesis of system allergic reactions and complications on the previous administration of serum horse divorced 1:100, mixes of monovalent serums (type A, B and E), or on monovalent serum antibotulinic or hypersensitivity to drugs;

— a contraindication to administration of serum antibotulinic at patients with botulism is development of an acute anaphylaxis when determining sensitivity to horse protein.

Overdose:

It is not established.

Storage conditions:

To store and transport according to the joint venture 3.3.2.1248-03 at a temperature from 2 °C to 8 °C in the place, unavailable to children. Freezing is not allowed. A period of validity - 2 years.

Issue conditions:

According to the recipe

Packaging:

1 dose - ampoules (1) complete with serum horse cleared divorced 1:100 (amp. 1 pieces) - a set (5) - packs cardboard.