Aveksim's asparkam

General characteristics. Structure:

Active ingredients: 175 mg of potassium of asparaginate of a gemigidrat, 175 mg of magnesium of asparaginate of a gemigidrat.

Excipients: potato starch, stearic acid, macrogoal 4000, silicon dioxide colloid.

Pharmacological properties:

Pharmacodynamics. Aveksim's asparkam is a source of potassium ions and magnesium, regulates metabolic processes. The mechanism of action is presumably connected with an asparaginate role as carrier of ions of magnesium and potassium in intracellular space and participation of asparaginate in metabolic processes. Thus, Aveksim's Asparkam eliminates an imbalance of electrolytes, reduces excitability and conductivity of a myocardium (moderate antiarrhytmic effect).

Pharmacokinetics. It is easily soaked up at intake and rather quickly removed by kidneys.

Indications to use:

Apply in complex therapy:

— chronic heart failure;

— coronary heart disease;

— hypopotassemias;

— disturbances of a cordial rhythm (including at a myocardial infarction, overdose of cardiac glycosides).

Route of administration and doses:

Appoint inside after food. The adult on 1-2 таб. 3 times/days. A course of treatment - 3-4 weeks. If necessary the course is repeated.

Features of use:

Use at renal failures. Use is forbidden to patients with an acute and chronic renal failure.

Use for children. Use of drug for children aged up to 18 years is forbidden.

Control of maintenance of potassium ions in a blood plasma is necessary.

Influence on ability to manage vehicles and the work demanding the increased concentration of attention. Clinical trials on drug impact assessment on ability to control of vehicles and mechanisms it was not carried out.

Side effects:

Nausea, vomiting, diarrhea, unpleasant feelings or burning in pancreatic area (at patients with anacid gastritis or cholecystitis), AV blockade, paradoxical reaction (increase in number of extrasystoles), a hyperpotassemia (nausea, vomiting, diarrhea, parasthesias), a gipermagniyemiya (erubescence of the person, feeling of thirst, decrease in the ABP, muscular weakness, increased fatigue, paresis, a coma, an areflexia, respiratory depression, spasms) are possible.

Interaction with other medicines:

Pharmakodinamicheskiye: combined use with kaliysberegayushchy diuretics (Triamterenum, Spironolactonum), beta adrenoblockers, cyclosporine, heparin, inhibitors of an angiotensin-converting enzyme, non-steroidal anti-inflammatory drugs increases risk of development of a hyperpotassemia up to development of arrhythmia and an asystolia.

Use of drugs of potassium together with glucocorticosteroids eliminates the hypopotassemia caused by the last. Due to the maintenance of potassium ions undesirable effects of cardiac glycosides decrease. Due to the maintenance of ions of magnesium reduces effect of Neomycinum, polymyxin B, tetracycline and streptomycin. Can strengthen the neuromuscular blockade caused by the depolarizing muscle relaxants (an atrakuriya bezilaty, a dekametoniya bromide, succinylcholine (chloride, bromide, iodide). Calcitriol increases concentration of ions of magnesium in a blood plasma, drugs of calcium reduce effect of magnesium.

Pharmacokinetic: the knitting and enveloping means reduce absorption of drug in zheludochno GIT (it is necessary to observe a 3-hour interval between their reception).

Contraindications:

— hypersensitivity to drug;

— disturbance of exchange of amino acids;

— acute and chronic renal failure;

— hyperpotassemia;

— gipermagniyemiya;

— insufficiency of bark of adrenal glands;

— AV conductivity disturbance (AV blockade of the I-III Art.);

— heavy myasthenia;

— hemolysis;

— arterial hypotension (systolic ABP less than 90 mm hg);

— age up to 18 years.

With care: pregnancy, lactation period.

Overdose:

Symptoms: hyperpotassemia, gipermagniyemiya.

Treatment: in/in Calcii chloridum, if necessary - a hemodialysis and peritoneal dialysis.

Storage conditions:

Drug should be stored in the place, dry, unavailable to children, at a temperature not above 25 °C. Period of validity 3 years. After a period of validity not to use drug.

Issue conditions:

Without recipe

Packaging:

8 pieces - packagings planimetric cell (6) - packs cardboard.
8 pieces - packagings planimetric cell (7) - packs cardboard.
10 pieces - packagings planimetric cell (5) - packs cardboard.
12 pieces - packagings planimetric cell (4) - packs cardboard.
12 pieces - packagings planimetric cell (5) - packs cardboard.
50 pieces - banks polymeric (1) - packs cardboard.
10 pieces - packagings bezjyacheykovy planimetric (1) - packagings group