Ringer

General characteristics. Structure:

Active ingredient: 8,6 g of sodium of chloride, 0,3 potassium of chloride, 0,25 g Calcii chloridum in terms of anhydrous.

Excipients: water for injections. Theoretical osmolarity - 307 ¼Äß¼/l.

Pharmacological properties:

Pharmacodynamics. Regidratiruyushchy means, has disintoxication effect, stabilizes water and electrolytic composition of blood. When using as means of completion of the volume of the circulating blood (VCB), because of a bystry exit from a circulatory bed in ekstravazalny space, effect remains within only 30-40 min. (in this connection solution is suitable only for short-term completion of OTsK).

Indications to use:

Shock, thermal injury, acute blood loss; dehydration; intestinal fistula; acute intestinal infections; medical plasma exchange; correction of water and salt balance at acute diffuse peritonitis and intestinal impassability.

Route of administration and doses:

Ringer enter intravenously kapelno, with a speed of 60-80 of caps/mines, or struyno.

The daily dose for adult 5-20 ml/kg, if necessary can be increased to 30-50 ml/kg.

Daily dose for children of 5-10 ml/kg, rate of administering of 30-60 caps/min., at shock dehydration 20-30 ml/kg originally enter. Course of treatment of 3-5 days.

At a medical plasma exchange enter in the volume twice exceeding the volume of remote plasma (1,2 – 2,4 l) in case of the expressed hypovolemia – in combination with colloidal solutions. The maximum volume of the entered solution – 3 l/days

Features of use:

In case of bystry introduction of large volume it is necessary to control an acid-base condition and level of electrolytes. Change рН leads blood to redistribution of potassium ions (decrease рН leads to increase in potassium ions in blood serum).

Freezing of drug on condition of preservation of tightness is not a contraindication to drug use. At opacification not to use contents of a bottle.

At a combination in sdrugy HP it is necessary to control compatibility visually.

Side effects:

Overhydratation, hypopotassemia, allergic reactions.

Interaction with other medicines:

Increase in a delay of sodium in an organism at a concomitant use of the following drugs is possible - NPVP, androgens, anabolic hormones, estrogen, corticotropin, mineralokortikoid, vazodilator, ganglioblokator.

At reception with kaliysberegayushchy diuretics, inhibitors of an angiotensin-converting enzyme and drugs of potassium the risk of development of a hyperpotassemia amplifies.

In a combination with cardiac glycosides the probability of their toxic effects increases.

Contraindications:

Hypersensitivity, hypernatremia, hyperchloremia, acidosis, heavy heart failure, wet brain, fluid lungs, chronic renal failure, the accompanying therapy by glucocorticosteroids, a hypopotassemia.

With care - heart failure, arterial hypertension, an abnormal liver function and kidneys.

Overdose:

At overdose there can be a disturbance of balance of water and electrolytes (a hypervolemia, a hypernatremia, a hyperpotassemia, a hypercalcemia, a hyperchloremia) and acid-base equilibrium. In most cases it is enough to stop administration of solution.

Storage conditions:

Period of storage 2 years. Not to use after the period of validity specified on packaging. In the place, dry, unavailable to children, at a temperature not above 25 °C.

Issue conditions:

According to the recipe

Packaging:

Solution for infusions on 200 and 400 ml in bottles glass for blood, infusional and transinfusional drugs, corked by rubber bungs and rolled by metal caps. For hospitals: on 28 bottles with a capacity of 250 ml and 15 bottles with a capacity of 450 ml stack in boxes from corrugated fibreboard, together with the application instruction in quantity. To the corresponding number of bottles