Комбилипен®

General characteristics. Structure:

Active ingredient: Benphothiaminum - 100 mg; a pyridoxine a hydrochloride - 100 mg; cyanocobalamine - 2 mkg

Excipients (kernel): Karmelloza (carboxymethylcellulose) povidone (коллидон 30), cellulose microcrystallic, talc, calcium stearate (calcium октадеканоат), polysorbate – 80 (twin-80), sucrose (sugar).

Excipients (cover): Hypro rod (hydroxypropyl cellulose), macrogoal (poly(ethylene oxide) 4000), povidone (polyvinylpirrolidone low-molecular medical), titanium dioxide, talc.

Description. Round biconvex tablets, film coated, white or almost white color.

Pharmacological properties:

The combined polyvitaminic complex. Effect of drug is defined by properties of the vitamins which are its part.

Benphothiaminum – a fat-soluble form of thiamin (B1 vitamin). Participates in carrying out nervous impulse.

Pyridoxine the hydrochloride (B6 vitamin) – participates in exchange of proteins, carbohydrates and fats, is necessary for a normal hemopoiesis, functioning of the central and peripheral nervous system. Provides synoptic transfer, processes of braking in the central nervous system, participates in transport of the sphingosine which is a part of a cover of a nerve participates in synthesis of catecholamines.

Cyanocobalamine (B12 vitamin) – participates in synthesis of nucleotides, is an important factor of normal growth, a hemopoiesis and development of epithelial cells; it is necessary for metabolism of folic acid and synthesis of a myelin.

Indications to use:

It is applied in complex therapy of the following neurologic diseases:

• epileptiform neuralgia;
• neuritis of a facial nerve;
• the pain syndrome caused by backbone diseases (intercostal neuralgia, a lumbar ishialgia, a lumbar syndrome, a cervical syndrome, a cervicobrachial syndrome, the radicular syndrome caused by degenerative changes of a backbone).
• polyneuropathy of various etiology (diabetic, alcoholic).

Route of administration and doses:

Pill should be taken after food, without chewing and washing down with a small amount of liquid. The adult on 1 tablet 1-3 times a day.
Course duration – according to the recommendation of the doctor. Treatment by high doses of drug within more than 4 weeks is not recommended.

Side effects:

Allergic reactions (itch, urtikarny rash), the sweating in some cases increased, nausea, tachycardia.

Interaction with other medicines:

The levodopa reduces effect of therapeutic doses of B6 vitamin. B12 vitamin is incompatible with salts of heavy metals. Ethanol sharply reduces thiamin absorption. During administration of drug reception of the polyvitaminic complexes including group B vitamins in structure is not recommended.

Contraindications:

Hypersensitivity to drug components, severe and acute forms of dekompensirovanny heart failure, children's age.

Use during pregnancy and breastfeeding
^{Комбилипен®} табс contains 100 mg of B6 vitamin and therefore in these cases drug is not recommended to be used.

Overdose:

Symptoms: strengthening of symptoms of side effect of drug.
Treatment: gastric lavage, reception of absorbent carbon, purpose of symptomatic therapy.

Storage conditions:

Tablets, film coated. 15 tablets in a blister strip packaging. 2 or 4 blister strip packagings together with the application instruction in a pack from a cardboard.

Issue conditions:

According to the recipe

Packaging:

In dry protected from light, the place, unavailable to children, at ^{a temperature not higher than 25 ° C}. A period of validity - 2 years. Not to use after a period of validity.