Deakura

General characteristics. Structure:

Active ingredient: 2,5 mg or 5 mg of biotin in 1 tablet.

Excipients: lactose, monohydrate; cellulose microcrystallic; povidone; кросповидон; magnesium stearate.

Pharmacological properties:

Pharmacodynamics. Biotin is vital for development and growth of cells. As a coenzyme plays an important role in a gluconeogenesis, a lipogenesis, biotransformation of propionates and splitting of a leucine.

Insufficiency of a bioyotin can arise at unbalanced food, long diets and the use of crude ovalbumin; at parenteral food; at a malabsorption sinyodroma, after a resection of a small intestine; at the mnozheyostvenny insufficiency associated with biotin a carboxymanhole; at patients who are on a hemodialysis.

Biotin (vitamin N, B7 vitamin) water-soluble vitamin of group B. In an organism biotin plays an important role in exchange of carbohydrates, fats and proteins and also the razyovitiya of cells is vital for normal growth. At hit in an organism biotin deyyostvut a carboxymanhole as a coenzyme, has insulinopodobny action and takes part in process of a gluconeogenesis (thanks to participation in synthesis of a glucokinase) owing to what it promotes stabilization of content of sugar in blood, improves function of nervyony system. Biotin is synergist of other vitamins of group B, folic acid, pantothenic acid, cyanocobalamine. There are data on a biotin uchayostiya in synthesis of purine nucleotides. Biotin is also a source of sulfur which priniyomat participation in protein synthesis - collagen, and thus positively influences structure of skin and its appendages (hair, nails).

Biotin comes to a human body with food stuffs, and also is synthesized by intestinal microflora. Absorption of free biotin begins already in an upper part of a small bowel. Here the molecule of biotin gets through a gut wall in a neizmenenyony look. Absorption happens mainly due to diffusion.

Pharmacokinetics. Extent of linkng of biotin with proteins of a blood plasma makes 80%. Concentration free or only slabosvyazanyony biotin in blood makes, as a rule, from 200 to 1200 mkg/l. Biotin is removed with urine (from 6 to 50 mkg/days) and a stake. Biotin is removed in not changed look (about 50%), and also in the form of biologically inert metabolites. The period of a poluyovyvedeniye depends on the size of the entered dose and makes nearly 26 h after introduction in a dose of 100 mkg/kg of body weight. At patients with insufficiency of biotinidase the elimination half-life after introduction of the same dose is reduced to 10–14 h.

Indications to use:

Treatment of the diseases caused by deficit of biotin: diseases of skin, nails, hair. Treatment of genetically caused enzymopathies associated with biotin (a multiple nedostayotochnost a carboxymanhole).

Route of administration and doses:

The recommended dose at treatment of diseases nogyoty, a hair, skin 1 tablet a day (that sootvetyostvut 2, 5 mg of biotin). For obtaining bystry effect it is recommended to double a day dose for the first week of treatment (the day dose makes 5 mg of biotin).

For treatment of genetically caused enzymopathies associated with biotin (multiple insufficiency a carboxymanhole), appoint 4-8 tableyotok (a day dose - to 20 mg of biotin) for 1-2 receptions a day. Duration of a course of treatment depends on character and the course of a disease and usually makes 1 month.

Features of use:

Drug contains lactose therefore patients who suffer from a rare hereditary neperenoyosimost of a galactose shortage of lactase or malabsorption of a glyukozygalaktoza should not use drug.

Use during pregnancy or a kormleyoniya a breast. Before use it is necessary to see a doctor.

Side effects:

Allergic reactions on skin are very seldom observed (urticaria). In case of any undesirable reakyotion it is recommended to stop treatment and to see a doctor.

Interaction with other medicines:

There is information that antikonvulsant reduce biotin level in plasma.

The use of a large number of crude eggs for 2-3 weeks can result in deficit of biotin.

Pantothenic acid in high doses konyokurirut with biotin therefore slenut to avoid their simultaneous use.

Contraindications:

The known hypersensitivity to biotin or to other components of drug.

Overdose:

About cases of overdose it is not reported.

Storage conditions:

Period of validity 3 years. To store in the place, unavailable to children, at a temperayotura it is not above 25 °C.

Issue conditions:

Without recipe

Packaging:

Glass bottle on 50, 100 and 200 tablets.