Ladasten

General characteristics. Structure:

Active ingredient: адамантилбромфениламин (adamantylphenyl amine) - 0,05 g and 0,10 g. Excipients: potato starch, cellulose microcrystallic, magnesium stearate.

Description. Tablets of color, white or white with a creamy shade, a round form, ploskotsilindrichesky with a facet. A dosage of 100 mg - with risky.

Pharmacological properties:

Pharmacodynamics. ^{Ладастен®} the adamantana, positively influencing indicators of physical and intellectual effeciency is derivative. In an action spectrum of drug the activating, anxiolytic, immunostimulating actions and elements of aktoprotektorny activity are combined. Ladastena® have no gipnosedativny and miorelaksantny properties, drug has no addiktivny potential. At its use, unlike action of typical psychostimulants, the hyper stimulation phenomena, and also after-effects in the form of exhaustion of functionality of an organism practically do not develop.

Terapevstichesky action. ^{Ладастена®} at patients with asthenic and alarming and asthenic frustration it is shown from the first days of its use in the form of a clear reduction of asthenic symptomatology, indicators of emotional pressure, somatovegetativny manifestations; drug promotes recovery of activity and increase in endurance.

The mechanism of action of Ladasten is connected with strengthening of emission of dopamine from presynaptic bombways, blockade of its return capture and strengthening of the biosynthesis caused by a gene expression tyrosine hydroxylase and also with its modulating influence on GAMK-benzodiazepinovy-hlorionoformny рецепторньш the complex eliminating decrease in the benzodiazepine reception developing at a stress. ^{Ладастен®} strengthens GAMK-ergichesky mediation, reducing an expression of the gene controlling synthesis of the GAMK-conveyor which is carrying out the return capture of a mediator.
^{Ладастен®} it is non-toxical (LD50 at rats exceeds 10000 mg/kg and more than by 100 times surpasses effective doses).

Pharmacokinetics. Time of achievement of the maximum concentration (Ttakh) makes 2-4 hours, the maximum concentration (Cmax) makes 363,3 ng/ml, an elimination half-life of drug (T1/2) - 11,21 hours.

Indications to use:

Asthenic conditions of various genesis, including at somatopathies and after the postponed infectious diseases.
Neurasthenia.

Route of administration and doses:

It is applied inside, irrespective of meal. Optimum single doses of drug of-50-100 mg; daily - 100-200 mg distributed on 2 receptions during the day. Drug should not be used after 16 o'clock in the afternoon. Duration of course use of drug makes 2-4 weeks.

Side effects:

Manifestations of excess activation and disorder of backfilling which do not demand drug withdrawal can be noted, reduction of its dose is reasonable. At the increased individual sensitivity to drug development of allergic reactions is possible.

Interaction with other medicines:

^{Ладастен®} reduces hypnotic effect of thiopental of sodium, does not weaken anxiolytic effect of benzodiazepines.

Contraindications:

Pregnancy, the lactation period, children's age up to 18 years, individual intolerance of drug.

Overdose:

At considerable overdose development of sedation is possible.

Treatment: nonspecific disintoxication therapy.

Storage conditions:

In the dry, protected from light place at a temperature not above 25 °C. To store in the places unavailable to children.

Period of validity 2 years. Not to use after the term specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Tablets of 50 mg and 100 mg. On 25 tablets in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished.
1 or 2 blister strip packagings together with the application instruction in a pack from a cardboard.