Solvin

General characteristics. Structure:

Active agent: Bromhexine hydrochloride of 4 mg

Excipients: propylene glycol, the benzoic acid, citric acid, sorbitol solution, sodium saccharin, menthol, vanillin, dye a sunset, essence pineapple, essence sweet orange, the water purified.

Pharmacological properties:

Pharmacodynamics. Drug renders, mucolytic (sekretolitichesky) and expectorant action. The mucolytic effect is connected with a depolymerization and fluidifying of mucoprotein and mukopolisakharidny fibers. The effect is shown in 2-5 days from an initiation of treatment. Stimulates production of the endogenous surfactant providing stability of alveolar cells in the course of breath.

Pharmacokinetics. At intake almost completely (99%) it is soaked up in digestive tract within 30 minutes. Bioavailability - about 80%. Also the blood-brain barrier gets through placental. In a liver is exposed to demethylation and oxidation, it metabozizirutsya to Ambroxol. T1/2 - 15 hours (owing to slow reversible diffusion from fabrics). It is removed by kidneys. At a chronic renal failure allocation of metabolites is broken. At repeated use can kumulirovat.

Indications to use:

The acute and chronic diseases of lungs which are followed by formation of a phlegm of the increased viscosity (bronchial asthma, a mucoviscidosis, tuberculosis, pneumonia, a tracheobronchitis, obstructive bronchitis, bronchiectasias, emphysema of lungs, a pneumoconiosis); thorax injuries.

Route of administration and doses:

Elixir:

Age of the patient	Dose, teaspoons
Children up to 2 years	1/2
from 2 to 6 years	1/2-1
from 6 to 14 years	1-2
Teenagers (since 14 years) and adults	2-3

At children treatment should be combined with postural drenazhy or vibration massage of a thorax. facilitating evacuation of a secret from bronchial tubes.

Features of use:

Solvin should apply with care the weakened patients, and also patients with the diseases of bronchial tubes which are followed by excessive accumulation of a secret; gastric bleeding in the anamnesis, a renal and/or liver failure.
Influence on ability to manage vehicles and to service mechanisms.
There are no data on an adverse effect of Bromhexine on ability to manage vehicles and to service mechanisms.

Side effects:

Seldom, at long administration of drug nausea, vomiting, the dispepsichesky phenomena, an aggravation of a peptic ulcer, allergic reactions are possible (skin rash, a face edema, rhinitis, etc.). increase in level of transaminases in blood serum. In these cases it is necessary to cancel drug.
If you have similar or others, the symptoms which are not stated above, consult with the doctor about further administration of drug!

Interaction with other medicines:

Solvin it is possible to appoint along with other drugs used at treatment of bronchopulmonary diseases Solvin do not appoint along with the medicines containing codeine as it complicates expectoration of the liquefied phlegm.
Solvin promotes penetration of antibiotics (erythromycin, cefalexin. Oxytetracyclinum) into pulmonary fabric.
Combined use of Solvin with some non-steroidal anti-inflammatory drugs (for example, salicylates. phenylbutazone or Butadionum) can cause irritation mucous a stomach.
Solvin is not compatible to alkaline solutions.
Before Solvin's reception consult with the doctor if you accept other medicines.

Contraindications:

- Hypersensitivity to drug components; including to lactose.
- pregnancy;
- lactation period;
- peptic ulcer of a stomach;
- the children's age up to 3 years (for tablets) If any of the specified cases concerns to you. consult about it with the doctor even prior to administration of drug.

Overdose:

Symptoms: nausea, vomiting, diarrhea, dispepsichesky frustration.
Treatment: artificial vomiting, a gastric lavage (in the first 1-2 h after reception).

Storage conditions:

Elixir: In protected from revenge light at a temperature not above 25 °C.
To protect from children.

Issue conditions:

Without recipe

Packaging:

Elixir - 60 or 120 ml in bottles from amber glass with a measured cap.