Glikodin

General characteristics. Structure:

Active agents: dextromethorphan hydrobromide of 10 mg, terpin hydrate of 10 mg, left menthol of 3,75 mg.

Excipients: sucrose, methylparahydroxysodium benzoate, пропилпарагидроксибензоат sodium, citric acid monohydrate, glycol, глицерол, sodium saccharinate, caramel, the alim (VVA), silicon purified the water distilled is sawn through.

Pharmacological properties:

Pharmacodynamics. Dextromethorphan possesses antibechic action. Oppressing excitability of the tussive center, suppresses cough of any origin. Has no narcotic, soothing and somnolent effect. The beginning of action - in 10-30 min. after reception, duration - during 5-6 h at adults and to 6-9 h - at children.
Terpin hydrate possesses expectorant action; increases secretory function of epithelial glands of respiratory tracts, increases the volume of secretion and reduces viscosity of the allocated secret.
Left menthol possesses moderate spasmolytic action. Facilitates a state at manifestation of symptoms of acute rhinitis, pharyngitis, laryngitis and bronchitis.

Pharmacokinetics. After intake dextromethorphan is completely soaked up in digestive tract, metabolized in a liver. The maximum concentration in a blood plasma is reached in 2 hours. To 45% of dextromethorphan can it is removed with urine.
Terpin hydrate is quickly soaked up from digestive tract after intake. Drug circulates in blood in not changed look and is removed through respiratory tracts, with urine and then to which it gives a specific smell. A part of drug is exposed in an organism to oxidation and is removed with urine in the form of phenols together with glucuronic acid.

Indications to use:

The acute and chronic diseases of a respiratory organs which are followed by the dry irritating cough.

Route of administration and doses:

Inside. Adults: 1 teaspoon (5 ml) 3-4 times a day. Children: - from 4 to 7 years - 1/4 teaspoons 3-4 times a day; - from 7 to 12 years - 1/2 teaspoons 3-4 times a day.

Features of use:

The persons using drug should refrain from driving and work with dangerous mechanisms.

Side effects:

Drowsiness, nausea, dizziness, itch, urticaria.

Interaction with other medicines:

Synergy interaction with narcotic antibechic drugs and other medicines, the oppressing TsNS. The possibility of interaction of dextromethorphan with monoamine oxidase inhibitors is not excluded. Therefore at the patients accepting monoamine oxidase inhibitors Glikodin it is desirable to exclude cough syrup.

Contraindications:

Hypersensitivity to one of drug components, bronchial asthma, pregnancy, the lactation period, children's age up to 4 years. With care - abnormal liver functions.

Overdose:

Symptoms: excitement, dizziness, respiratory depression, lowering of arterial pressure, tachycardia, dispepsichesky frustration.
Treatment: artificial ventilation of the lungs, symptomatic treatment.
There is a specific antidote Naloxonum which can be applied at overdose in 100 and more times.

Storage conditions:

To store in the place protected from light at a temperature not above 25 °C.
To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

On 50 ml; 100 ml in round bottles of dark glass with the aluminum screw-on cover. Each bottle together with a measured plastic spoon and the application instruction is placed in a pack cardboard.