Аллергодил®

General characteristics. Structure:

Active agent: Azelastina hydrochloride of 0,5 mg;

Excipients: a droksipropilmetiltsellyuloz (gipromelloz), dinatrium эдетат, a benzalkoniya chloride, sorbitol of 70%, sodium hydroxide, water for injections.
Description: Solution, colourless, transparent or almost transparent, almost free from mechanical inclusions.

Pharmacological properties:

Azelastin, derivative a ftalazinona, is strong antiallergic means of long action, with selective antagonistic properties to H1 receptors. At intraocular use additional antiinflammatory and membrane stabilizing effects of an azelastin are shown: азеластин slows down synthesis and release of mediators of an early and late phase of allergic reactions, for example, of leukotriene, a histamine, a factor of activation of thrombocytes and serotonin; reduces quantity of ICAM-1 (a cell of molecular adhesion) and eosinophial cells.

Clinically significant impact on QT (QTc) an interval it is not revealed even at prolonged use of high doses of an azelastin.

Pharmacokinetics. Even at numerous intraocular use of eye drops of Allergodil (on 1 drop in each eye four times a day) the maximum concentration of an azelastin in a blood plasma very low also come to light on a limit or below a limit of measurements.

Indications to use:

- prevention and treatment of seasonal allergic conjunctivitis;
- treatment of nonseasonal (year-round) allergic conjunctivitis.

Route of administration and doses:

Seasonal allergic conjunctivitis: in the absence of other recommendations of the doctor to adults and children of 4 years to dig in 2 times a day (in the morning and in the evening) on 1 drop in each eye. If necessary the dose is increased to 4 times a day on one drop in each eye.

In case of alleged influence of allergen drug is used with the preventive purpose.

Nonseasonal (year-round) allergic conjunctivitis: in the absence of other recommendations of the doctor to adults and children of 12 years to dig in 2 times a day (in the morning and in the evening) on 1 drop in each eye. If necessary the dose is increased to 4 times a day on one drop in each eye.

Features of use:

Allergodil can be used for treatment of infectious diseases of eyes only in complex therapy according to the recommendation of the doctor.

At use of eye drops it is not recommended to carry contact lenses.

Side effects:

Ophthalmologic manifestations: increase in sensitivity of an eye, feeling of a foreign body, discoloration of a conjunctival cover, irritation, morbidity, an itch, reddening, hypostasis, the raised slezootdeleniye. Seldom – a xerophthalmus, a blepharitis.

The general manifestation: диспноэ, disgeziya, xeroderma.

Interaction with other medicines:

It is not revealed. In case of the accompanying therapy by other eye drops, it is necessary to dig in them in eyes with an interval not less than 15 minutes.

Contraindications:

- Hypersensitivity concerning active agent or other components of drug;
- Age up to 4 years.

Use at pregnancy and a lactation

In spite of the fact that when testing the doses which are repeatedly exceeding therapeutic range any certificate on teratogenic action is not received, use of an azelastin of eye drops in the first trimester of pregnancy, and also in the period of a lactation is not recommended.

Overdose:

Data on overdose of drug are absent.

Storage conditions:

Period of validity 3 years. After opening of a bottle drug should be used within 4 weeks. Not to use after the period of validity specified on packaging. At a temperature not above 25 °C in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Solution (drops eye) on 6 ml or 10 ml of solution in a bottle from translucent polyethylene of high density with a dropper from polyethylene of low density with a white cap from polyethylene of high density.

1 bottle together with the application instruction is placed in a cardboard pack.