Зирган®

General characteristics. Structure:

Active ingredient: 1,5 mg of a gantsiklovir.

Excipients: benzalkoniya chloride, carbomer, sorbitol, sodium q.s hydroxide. to рН 7.4, the water purified.

The antiviral means applied in ophthalmology.

Pharmacological properties:

Pharmacodynamics. Antiviral drug for topical administration in ophthalmology. Gantsiklovir is a nucleoside which inhibits replication of human viruses of a herpes simplex 1 and 2 types. In the infected cells ганцикловир it will be transformed to an active form of a gantsiklovir - ганцикловиртрифосфат. Phosphorylation happens preferential in the infected cells, and concentration of a gantsiklovirtrifosfat in not infected cells is 10 times less.

Antiviral activity of a gantsiklovirtrifosfat consists in inhibition of synthesis of virus DNA with use of two mechanisms: competitive inhibition of a virus DNA polymerase and live broadcast in virus DNA with disturbance of termination of a chain and prevention of its replication.

Pharmacokinetics. After instillation of drug in an eye of 5 times/days within 11-15 days at treatment of a superficial herpetic keratitis of concentration of a gantsiklovir in plasma were very low: on average 0.013 mkg/ml (0=0.037).

Indications to use:

— treatment of the acute superficial keratitis caused by a herpes simplex virus.

Route of administration and doses:

Drug is dug in in the lower conjunctival sac of the affected eye on 1 drop of 5 times/days to a full reepitelization of a cornea, then - on 1 drop of 3 times/days, within 7 days.

Duration of treatment should not exceed 21 days.

Features of use:

Use at pregnancy and feeding by a breast. Drug is contraindicated at pregnancy and in the period of a lactation. Women of childbearing age require contraception use. Because of the genotoxicity revealed in experiments on animals, the men applying Zirgan® are recommended to use reliable methods of contraception during treatment and within three months after its end.

Use for children. It is contraindicated at children's age up to 12 years.

This medicine is not intended for treatment of a Cytomegaloviral infection of a retina.

Efficiency concerning the keratoconjunctivites caused by other types of viruses was not established.

No special researches at patients with an immunodeficiency were conducted.

Benzalkoniya chloride can cause irritation of eyes and discoloration of soft contact lenses. It is not necessary to allow contact of drug with soft contact lenses. It is necessary to remove contact lenses before use of drug and to repeatedly establish them not earlier than in 15 minutes after an instillation.

Influence on ability to driving of motor transport and to control of mechanisms. The patient has to abstain from driving or works with a difficult technique in case of any vision disorder during treatment as drug.

Side effects:

From an organ of sight: the most frequent side effects are sight misting (60%), irritation of an eye (20%), a dot keratitis (5%) and a conjunctiva hyperemia (5%).

Interaction with other medicines:

It is not revealed.

Contraindications:

— pregnancy;

— breastfeeding period;

— children's age up to 12 years;

— hypersensitivity to a gantsiklovir, an acyclovir or any of drug components.

Overdose:

Data on overdose are absent.

Storage conditions:

Drug should be stored in the place, unavailable to children, at a temperature not above 25 °C. A period of validity - 3 years, after opening of a tuba - 4 weeks.

Issue conditions:

According to the recipe

Packaging:

5 g - tubas with a tip, the screwing-up cap and a removable support for storage of a tuba upside down after opening (1) - a pack cardboard.