Гастал®

General characteristics. Structure:

Active agents: carbonate magnesium hydroxide aluminum gel of 450,0 mg, magnesium hydroxide of 300,0 mg;
excipients: lactoses monohydrate of 111,5/112,0 mg, Mannitolum of 110,0/112,0 mg, starch of prezhelatinizirovanny 32,0/32,0 mg, silicon dioxide of colloid 2,0/2,0 mg, croscarmellose sodium (type A) of 50,0/50,0 mg, aspartame 2,5/2,0 of mg, magnesium mg stearate 6,0/6,0, fragrance mint 11890-71 (for tablets with mint taste) 6,0 mg or fragrance cherry E 9407963 (for tablets with cherry taste) 4,0 mg.

Description:
Round tablets of white or almost white color with a smooth surface and a facet, with mint or cherry taste.

Pharmacological properties:

Pharmacodynamics. Drug Gastal is a buffer antacid which eliminates a hyperoxemia and the corresponding dysfunctions of a stomach. Gel of aluminum of magnesium hydroxide of a carbonate works as the antiacid buffer, reducing a hyperoxemia of a gastric juice to physiological level (рН 3-5), promoting, thus, normal digestion without increase in secretory activity. Magnesium the carbonate quickly has neutralized effect for an appreciable length of time, strengthening antiacid effect.

Antiacid effect of drug begins immediately after acceptance of a tablet, duration makes about 2 hours. One tablet Gastala® neutralizes 21,5 mmol of hydrochloric acid. In the recommended dose drug raises рН to 3 - 5, элиминируя, thus, free hydrochloric acid. Гастал® suppresses effect of pepsin, lysolecithin, and bile acids.

It is proved that the antacids containing aluminum hydroxide strengthen protective and regenerative processes in a mucous membrane of a stomach. The cytoprotective action of ions of aluminum includes: increase in secretion of mucin and Natrii hydrocarbonas, activation of E2 and N0 prostaglandin, accumulation of an epidermal growth factor in the place of injury of a mucous membrane, increase in concentration of phospholipids in stomach walls. The mechanism of this action is up to the end not studied.

Pharmacokinetics. The drug Gastal® does not possess systemic action at patients with normal function of kidneys.

After interaction with hydrochloric acid of a gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline environment of intestines and is removed by intestines in the form of insoluble salts. Magnesium hydroxide reacts with hydrochloric acid in a gastric juice with formation of magnesium of chloride which possesses the osmotic soft laxative action neutralizing the fixing effect of aluminum of hydroxide in a small intestine. Ions of magnesium are removed by intestines in the form of an insoluble carbonate.

Indications to use:

Symptomatic treatment of the hyperacid states (including followed by heartburn) associated with a peptic ulcer of a stomach and duodenum, gastritis, a reflux esophagitis.

Route of administration and doses:

Adults
Drug is recommended to accept on 1-2 tablets of 4-6 times a day approximately in an hour after meal and before going to bed, but no more than 8 tablets a day. Duration of reception should not exceed 2 weeks. Similar doses are recommended for treatment of heartburn irrespective of meal.

Children from 6 to 12 years
Drug is recommended to be accepted in the dose making a half from the recommended dose for adults. A pill should be taken inside, gradually rassasyvy in a mouth.

Features of use:

Reduced doses and the reduced period of treatment it is shown for patients with the lost weight and for children.

Patients with reduced function of kidneys should avoid long administration of drug in the raised doses. Continuous reception is possible more than 2 weeks only after consultation of the doctor.

Influence on ability to manage motor transport and to work with mechanisms: does not influence.

Side effects:

When using drug in the recommended doses side undesirable side reactions meet seldom: nausea, lock, diarrhea, change of flavoring feelings. In exceptional cases there are allergic reactions.

Interaction with other medicines:

Drug Gastal increases activity of a levodopa and Acidum nalidixicum. Activity of tetracyclines, hinolon, acetylsalicylic acid, an isoniazid, Naproxenum, iron preparations, indometacin, aminazine, [3 blockers, a diflunizala, H2-histamine blockers, A, D, E, K vitamins, indirect anticoagulants, barbiturates and cardiac glycosides decreases. In this regard, above-mentioned drugs should be accepted for an hour to or 2 hours after administration of drug Gastal. M-holinoblokatory, slowing down motility of a stomach, extend effect of drug.

Contraindications:

Hypersensitivity to salts of aluminum, magnesium or other components of drug; heavy renal failure; the children's age is younger than 6 years.

With care
Chronic renal failure; the children's age is more senior than 6 years.

Use at pregnancy and during breastfeeding
Drug Gastal has no systemic action, is not allocated with breast milk. Nevertheless, purpose of drug during pregnancy and in the period of a lactation perhaps only under control of the doctor.

Overdose:

Symptoms of acute overdose were not registered.
Development of more expressed undesirable reactions from digestive tract (a lock, diarrhea) is possible. The symptomatic treatment is shown.

Storage conditions:

At a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity 3 years. Not to apply after the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

Tablets for a rassasyvaniye (cherry, mint).
On 6 tablets in the blister from PVH/PVDH and aluminum foil.
On 4 or 8 blisters together with the application instruction in a cardboard pack.