Nystatin

General characteristics. Structure:

Active agent: PIECE nystatin 250000 or 500000.

Excipients: lactose (sugar milk), potato starch, polyvinylpirrolidone low-molecular medical (povidone), gelatin, talc, acid stearin, microcrystallic cellulose, titanium dioxide, yellow water-soluble dye (KF-6001), KE 10-16 emulsion, vanillin, twin-80.

Description: tablets, coated, color, light yellow with a greenish shade, a biconvex form,  with a vanillin smell, on cross section are visible two layers.

Pharmacological properties:

The antibiotic of half-yen group produced by an actinomyce of Streptomyces noursei highly active concerning drozhzhepodobny mushrooms of the sort Candida. In structure of an antibiotic there are double bonds possessing a high tropnost to styrene structures of a cytoplasmic membrane of mushrooms that promotes embedding of a molecule of drug in a cell membrane and to formation of a large number of channels via which uncontrolled transport of electrolytes is carried out; increase in osmolarity in a cell leads to her death. Tolerance develops slowly.

Pharmacokinetics. Possesses weak resorptive action, it is practically not soaked up in digestive tract.

Indications to use:

Prevention of candidiasis mucous digestive tract at prolonged treatment by antibacterial agents (especially at the exhausted and weakened patients).

Route of administration and doses:

Apply inside, irrespective of meal.

The adult appoint 500000 PIECES of 4-8 times a day. 

To children aged from 1 year up to 5 years – 250000 PIECES 3-4 times a day, are more senior than 13 years – on 250000-500000 PIECES 4 times a day. 

Course duration – 10-14 days. If necessary in a week the course can be repeated.

Features of use:

It is not described.

Side effects:

Nausea, vomiting, diarrhea, abdominal pains, hyperthermia, fever, allergic reactions.

Interaction with other medicines:

It is not described.

Contraindications:

Hypersensitivity, liver failure, pancreatitis, peptic ulcer of a stomach and duodenum, pregnancy, breastfeeding period.

Overdose:

Cases are not described.

Storage conditions:

List B. In the dry, protected from light place, at a temperature from 12 to 20 °C.
In places unavailable to children. Period of validity 2 years. Not to use after a period of validity.

Issue conditions:

According to the recipe

Packaging:

Tablets, coated, 250000 PIECES and 500000 PIECES.

On 20 tablets in banks from orange glass with the tense covers or in bottles polyethylene with the screwed covers. On 10 tablets in a blister strip packaging.

Each can of orange glass or 2 blister strip packagings with the application instruction are placed in a pack from a cardboard. Bottles polyethylene  with application instructions place in a box from a cardboard. On 1 kg or 5 kg in a package from a film polyethylene, enclosed in a bag from paper bag or in a box from a cardboard.