Elixir chest

General characteristics. Structure:

Active ingredients: 6,21 g or 10,35 g of a licorice root of extract of dense, 0,414 g or 0,69 g of ammonia of the solution concentrated.

Excipients: anisic oil, alcohol of 90%, the water purified. 

Mucolytic vegetable medicine with protivospalitelny, spasmolytic and easy laxative action.

Pharmacological properties:

Pharmacodynamics. The combined medicine. Pharmacological properties of medicine are caused by availability of extract of a licorice root in it dense and solution of ammonia.

Extract of a licorice root contains triterpenovy saponins (glycyrrhizin, glycyrrhizic acid), flavonoidny glycosides (ликвиритозид, ликвиритин, ликвиритигенин, etc.), pectinaceous substances.

Glycyrrhizin has a promoting effect on activity of a ciliate epithelium and strengthens secretory function of mucous membranes of upper respiratory tracts, facilitates expectoration.

Glycyrrhizic acid and its metabolites inhibit peripheral metabolism of cortisol and cause psevdoaldosteronopodobny effect, has an inhibiting effect on enzyme 11 - beta гидроксистероиддегидрогеназу that leads to reduction of transformation of cortisol into a cortisone. Cortisol has mineralokortikosteroidny activity, causes reduction of potassium concentration in blood serum and increase in content of sodium that leads to a liquid delay in an organism, to increase in body weight and arterial hypertension.

Flavonoidny glycosides have spasmolytic effect on unstriated muscles.

The isoflavonoid of Glabridin of extract of a root of a glycyrrhiza has antiinflammatory effect at the expense of inhibition of activity of a tyrosinase, synthesis superoxide-anions and activities of cyclooxygenase. The flavonoid of Licoricidin has antiinflammatory activity, having the braking effect on isoPAF (a trombotsitny factor of activation) of acetyltransferase. Isoliquiritigenin flavonoid, aldozoreduktaza inhibitor, renders antithrombocytic effects at the expense of inhibition of cyclooxygenase, a lipoxygenase and activity of peroxidase. Antiinflammatory effect of glycyrrhizin is connected with its antithrombic action at the expense of inhibition of the aggregation of thrombocytes induced by thrombin.

Licorice have easy laxative effect.

Ammonia possesses irritant action which leads to initiation of the terminations of sensory nerves of upper respiratory tracts and reflex stimulation of the center of breath.

Indications to use:

As an expectorant at the infectious and inflammatory respiratory diseases which are followed by formation of difficult separated phlegm (including tracheitis, a tracheobronchitis, bronchitis).

Route of administration and doses:

The elixir chest contains vegetable natural components, at storage emergence of an insignificant deposit is possible that does not exert impact on efficiency of medicine. Before the use it is necessary to shake up.

For adults (including patients of advanced age) inside till 20-30 drops, it is desirable divorced in the small volume of warm water, 3-4 times a day in 30 minutes prior to food or in 1 hour after food.

To children aged from 3 years appoint 3-4 times a day inside so many drops to reception how many years to the child, before use it is necessary to dissolve medicine in the small volume of warm water.

Duration of use makes 1-2 weeks. More prolonged use is defined individually by the doctor. Duration of treatment of children aged till 6 years no more than a week.

If the next reception of medicine was missed it is not necessary to increase the dose following it, and to continue the use of medicine in the dose recommended by the doctor.

Features of use:

As medicine has laxative effect, with care it is necessary to apply in the presence of diarrhea. Not to accept at the same time with the stimulating laxatives or other medicines which can increase an electrolytic imbalance.

At prolonged use of high doses of medicine during the long period water accumulation can increase, causing hypostases of hands and legs. Excretion of sodium decreases and potassium increases. Arterial pressure can increase.

The root Glycyrrhizae should not be accepted along with corticosteroids.

The patients accepting glycyrrhiza drugs should not use other products containing a licorice because of risk of the serious undesirable phenomena which can occur, such as hypopotassemia, arterial hypertension, disturbances of a cordial rhythm.

Drugs of a glycyrrhiza should be used with care at the patients having a hypertension, diseases of kidneys, a liver and cardiovascular diseases at a hypopotassemia as they are more sensitive to adverse effects of a glycyrrhiza.

If the pharyngalgia or cough remains more than three days, it is necessary to see a doctor.

Due to the increase in loss of potassium, it is not necessary to appoint a root of a glycyrrhiza for long use with thiazide and loopback diuretics or cardiac glycosides.

Because of reduction of release of sodium and water, efficiency of the drugs used in treatment of arterial hypertension at combined use with extract of a glycyrrhiza can be reduced.

It is not necessary to appoint a root of a glycyrrhiza in a combination to Spironolactonum or amiloride.

Sharing with antiarrhytmic drugs (прокаиномид, quinidine) increases risk of development of a hypopotassemia and heavy ventricular tachycardia like torsades de pointes.

Drivers of vehicles and persons whose profession is connected with the increased concentration of attention at reception of the Elixir chest should consider about content of ethanol in it. The ethanol content in the maximum single dose makes 0,3 ml, in the maximum daily dose – 1,2 ml.

Due to the lack of adequate data use at children and teenagers aged up to 18 years is recommended only to destination and under observation of the doctor.

Pregnancy and period of a lactation: the drug safety from a glycyrrhiza root during pregnancy and during feeding by a breast was not established. As a precautionary measure medicine should not be applied during pregnancy and during feeding by a breast.

Researches on animals established existence of reproductive toxicity.

Side effects:

Allergic reactions at individual intolerance of components of medicine; gastrointestinal frustration (nausea, vomiting); neurologic frustration (sometimes perhaps short excitement, and then oppression of the central nervous system).

At prolonged use the hypopotassemia, a hypernatremia, a liquid delay in an organism up to emergence of hypostases are possible, arterial hypertension, functional disturbances of action of the heart.

At emergence of the undesirable phenomena reception of medicine it is necessary to stop and see the attending physician.

Interaction with other medicines:

Simultaneous use of the Elixir chest with thiazide and loopback diuretics increases risk of development of a hypopotassemia. The hypopotassemia caused by prolonged use of medicine can exponentiate toxic effect of cardiac glycosides.

At a concomitant use of medicine with glucocorticosteroids increase in an elimination half-life of cortisol is possible.

Simultaneous use of the Elixir chest with the medicines reducing formation of a phlegm and also antibechic medicines of the central and peripheral action since suppressing a tussive reflex is not recommended, they slow down release of respiratory tracts from a secret, worsen aerodynamics of a respiratory path and processes of oxygenation of lungs.

At reception of the Elixir chest along with antibacterial agents the similar effect is possible Disulfiramum.

Contraindications:

The increased individual sensitivity to medicine components, bronchial asthma, gastritis, a peptic ulcer of a stomach and duodenum in the period of an aggravation, a hypopotassemia, a chronic renal failure, a diabetes mellitus, arrhythmias, arterial hypertension and an idiopathic hypertensia, chronic hepatitis, cholestatic diseases of a liver, cirrhosis, alcoholism, a craniocereberal injury, brain diseases, pregnancy, the lactation period, children's age up to 3 years.

Overdose:

Strengthening of by-effects is possible.

Treatment: Dose decline or temporary termination of reception of medicine. If necessary carry out symptomatic therapy.

Storage conditions:

In the place protected from light at a temperature not over 20 ºС. To store in the place, unavailable to children. A period of validity - 3 years. Not to use after the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

30 ml in the bottles from dark glass corked by traffic jams droppers in packaging No. 1. 50 ml in the bottles from dark glass corked by traffic jams droppers in packaging No. 1.