BIOSPORIN - BIOFARM

General characteristics. Structure:

Active ingredients: one dose of Biosporin-Biofarma contains living microbic cells of Bacillus subtilis of UKM V-5007: 1 · ^{109 - 8·109},  Bacillus licheniformis of UKM V-5514: 1 · ^{108 - 2·109};

excipients: sucrose, gelatin, sodium chloride.

Main properties: the crystal or porous lyophilized mass of living microbic cells  of Bacillus subtilis of UKM V-5007 and Bacillus licheniformis of UKM V-5514 from light gray till beige or dark gray color (it is possible with light-or a dark brown shade); specific smell, sweetish taste.

Pharmacological properties:

Shows high antagonistic activity in relation to pathogenic and opportunistic microbes and does not influence representatives of normal microflora. Sinteziret a complex of the enzymes exerting the stimulating and regulating impact on process of digestion and promoting improvement of digestion of food.

Indications to use:

Biosporin-Biofarma is intended for treatment of children (since 3 months) and adults:

- easy and average forms, and also the severe forms sick with the acute intestinal infections (AII) (at patients with contraindications to an antibioticotherapia) caused pathogenic and opportunistic (including steady against antibiotics) microorganisms ( Salmonella spp., Shigella spp., enteropathogenic E. сoli, Proteus spp., Staphylococcus spp., Candida spp.);

- the persons who transferred OKA (in case of allocation of pathogenic and opportunistic microorganisms, and also at intestines dysfunction);

- for the purpose of intestinal microflora correction (at the dysbacterioses which arose owing to an antibioticotherapia or other reasons);

- for the purpose of prevention it is purulent - septic complications in the postoperative period;

- in gynecologic practice: at vulvovaginal candidiasis at women of reproductive age, including pregnant women; at a bacterial vaginosis (з the rehabilitation purpose after the termination of a course of antibacterial therapy);

- in dental practice: at chronic recurrent stomatitis at children.

Route of administration and doses:

Drug is used in the form of suspension (see ″ Features of use ″) inside (orally), and also by means of tampons, applications and irrigations (intravaginalno).

 For children:

- at treatment of OKA (dysentery, a salmonellosis, food toxicoinfections, etc.) – on 1 dose 2 times a day within 5-7 days (orally);

- at an aftercare of convalescents after OKA – on 1 dose 2 times a day within 5 days (orally);

- at intestinal dysbioses – on 1 dose 2-3 times a day within 10-20 days (orally);

- at treatment of chronic recurrent aphthous stomatitis – on 2 doses 2 times a day on an extent of 14 days (orally after food and rinsing of a mouth); after a priyom of drug not to use food and not to drink on an extent of 40-60 min.

For adults:

- at treatment of OKA – on 2 doses 3 times a day within 5-7 days (orally);

- at an aftercare of convalescents after OKA – on 2 doses 2 times a day within 5 days, if necessary up to 2 weeks (orally);

- for prevention it is purulent - septic complications in the postoperative period - on 2 doses 2 times a day within 5-7 days before operation and on 2 doses 2 times a day within 10 days after operation (orally);

- for treatment of vulvovaginal candidiasis and a bacterial vaginosis - on 2 doses once a day within 5-10 days in the form of irrigations and applications with exposure of 6-12 hours.

Orally drug sledet apply in 30-40 min. prior to food.

If necessary the course of treatment can be repeated.

Features of use:

For receiving suspension of drug, in a glass pour necessary quantity of boiled chilled water (from calculation one teaspoon on 1 dose of drug).  Dissolve with a small amount of this water drug in a bottle. Within 1-2 min. homogeneous suspension from light gray till beige or dark gray color is formed (it is possible with light-or a dark brown shade). Contents of a bottle are transferred to a glass, mixed. Half-scientific suspension is applied  inside (orally - through a mouth), to vaginal irrigations and impregnation of tampons for intravaginalny introduction. Divorced drug is not subject to storage.

Use during pregnancy and feeding by a breast. Drug can be used during pregnancy and feeding by a breast.

Side effects:

It is not revealed.

Interaction with other medicines:

It was not studied.

Contraindications:

It is not established.

Overdose:

It was not studied.

Storage conditions:

To store in the dry, protected from light place, at a temperatua it is not above 25 °C.

Issue conditions:

Without recipe

Packaging:

On 1, 2 or 5 doses of drug at bottles with a capacity of 5 ml. On 5 ili10 bottles in a pack.