Карнитекс

General characteristics. Structure:

Active ingredient: 295 mg acetyl - L - a hydrochloride carnitine in 1 capsule.

Excipients: cellulose microcrystallic, silicon dioxide colloid (aerosil), кросповидон, type A, magnesium stearate.

Gelatinous solid capsules: titanium dioxide, gelatin.

Pharmacological properties:

Pharmacodynamics. Acetyl - L - a carnitine (ALCOHOL) - the natural biologically active agent which is present at an organism in various bodies and fabrics including in the central nervous system (CNS), participates in metabolism of fatty acids and carbohydrates. Pharmacological effect of ALCOHOL is in many respects caused by metabolic effects of a L-carnitine and the acetyl groups which are its part. Acetyl - L - a carnitine - biologically active form of a L-carnitine, key substance in the course of a catabolism of fats and formation of energy in an organism.

ALCOHOL is synthesized in brain fabric, a liver and kidneys from a L-carnitine with the participation of karnitinatsetiltransferaza enzyme. As ALCOHOL delivers the activated acetate directly in structure of a mitochondrion for education atsetil-KOA, participating in a cycle of tricarboxylic acids, without additional expenditure of energy, it represents easily available substrate for start of volatile exchange processes in a mitochondrion. Due to full power providing an organism at smaller consumption of oxygen with ALCOHOL fabrics protects brain tissues from ischemia.

Thanks to the structural similarity to acetylcholine, ALCOHOL has cholinomimetic effect, and also shows neuroprotective properties. It increases cellular concentration of aspartic and glutaminic acid, and also taurine, at prolonged use increases density of N - methyl - In - aspartate - receptors in a hippocampus, bark and a striatum and interferes with reduction of their density in the conditions of aging. ALCOHOL strengthens effects of serotonin, and also protects brain cells from neurotoxic effects of ammonia and a glutamate.

Results of pilot studies showed that ALCOHOL has anti-anamnestic activity, ability to improve training processes, indicators of not associative memory, to render positive effect on mnestichesky functions in the conditions of experimental model of Alzheimer's disease, without causing at the same time side effects of sedative and myorelaxation character.

ALCOHOL increases energy development, being easily available substrate for start of volatile exchange processes in a mitochondrion. Stimulates protein synthesis and phospholipids for creation of membranes, improves regeneration processes. At pathology has neurotyre-tread effect, especially in relation to neurons and their organellas (mitochondrions), and also neurotrophic action due to modulation of activity of the nerve growth factor (NGF). ALCOHOL can accelerate regeneration of nervous cells at traumatic and endocrine damages of peripheral nerves on experimental models of polyneuropathy at diabetes.

The noticeable effect of ALCOHOL renders on delay of processes of aging due to strengthening of transport of fatty acids in a mitochondrion and maintenance of their work at the level of a young organism.

Pharmacokinetics. Acetyl - L - a carnitine is soaked up by active transport or simple diffusion through a mucous membrane of digestive tract (on condition of its high concentration). Including cerebral, ALCOHOL comes to the majority of fabrics from a circulatory bed (an exception the liver and a small intestine make) in not changed look. It is brought out of an organism by kidneys.

In researches at oral administration (500 mg/kg) the maximum concentration of drug in blood steps on animals in 4 hours and makes 40 µî/l within 8 hours.

Indications to use:

In complex therapy:

- initial displays of dementia of altsgeymerovsky type (Alzheimer's disease) and cerebral and vascular dementia.

- peripheral neuropathy, including at a diabetes mellitus.

- primary and secondary involutional syndromes against the background of chronic ischemia.

- decrease in intellectual working capacity, for improvement of concentration of attention and memory.

Route of administration and doses:

Inside, washing down with enough water. The single dose of drug for adults usually makes 1 - 4 capsules, the daily dose makes 6-12 capsules. Course of treatment from 1 to 4 months.

At Alzheimer's disease the recommended dose of 1500-4000 mg a day in two-three receptions. At involutional syndromes of 1500-2000 mg a day. At neuropathy the daily dose makes 1500-3000 mg.

Features of use:

Pregnancy and lactation. Special researches about a possibility of use at pregnancy and during breastfeeding were not conducted. Drug is used only if the estimated advantage for mother exceeds risk for a fruit. For the period of treatment it is necessary to stop breastfeeding.

Influence on ability to manage vehicles and mechanisms. Does not influence ability to manage vehicles and to perform the work demanding the increased concentration of attention and speed of psychomotor reactions.

Side effects:

Allergic reactions, gastrointestinal frustration, nausea, heartburn, concern, emergence of a specific smell in urine, sweat is possible and began to smell from a mouth.

If any of the undesirable reactions specified in the instruction are aggravated, or you noticed any other undesirable reactions which are not specified in the instruction, report about it to the doctor.

Interaction with other medicines:

It is not recommended to apply along with atsenokumoroly.

It is necessary to be careful at simultaneous use with warfarin.

Contraindications:

Hypersensitivity to an atsetilkarnitin or other components of drug. Children's age up to 18 years (efficiency and safety are not established).

Overdose:

Now cases of overdose are not registered.

Storage conditions:

In the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children. A period of validity - 2 years. Not to apply after the period of validity specified on packaging.

Issue conditions:

According to the recipe

Packaging:

On 10, 15, 20 or 30 capsules in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished. On 1, 2, 3, 4, 5, 6 blister strip packagings together with the application instruction place in a pack from a cardboard.