Raunatinum

General characteristics. Structure:

Active agent: Raunatinum of 0,002 g.

Excipients: sugar, glucose, calcium stearate, potato starch, kros-povidone (Kollido CL), stearic acid, calcium stearate, magnesium carbonate the main, aerosil, polyvinylpirrolidone middlemolecular, gelatin, talc, beeswax, titanium dioxide pigmental, dye quinolinic yellow (E-104) or yellow water-soluble dye (KF-6001), церулезум.

Pharmacological properties:

Raunatinum - the sum of alkaloids from Rauwolfia roots. Alkaloids are presented by Reserpinum, serpentine, Ajmalinum, etc. The general content of alkaloids in terms of dry matter - not less than 90%.
Drug of a plant origin, has hypotensive effect and antiarrhytmic action, and also sedative influence. The last is expressed less, than at Reserpinum, but on hypotensive action drug does not concede to Reserpinum. In some cases Raunatinum is transferred better than Reserpinum. The hypotensive effect of drug develops more slowly, than at Reserpinum.

Pharmacokinetics. Drug is well soaked up from digestive tract, but more slowly, than Reserpinum therefore hypotensive action develops gradually.
It is removed with a stake about 60% of drug, with urine - 8%. The elimination half-life makes 45-168 h.

Indications to use:

Arterial hypertension (easy and moderate severity).

Route of administration and doses:

Raunatinum is appointed the adult, inside, after food.

Begin, as a rule, with reception for night of 1 tablet containing 0,002 g (2 mg) of the sum of alkaloids; for the 2nd day accept on 1 tablet 2 times a day; for the 3rd day - 3 tablets, bringing the general dose to 4-5-6 tablets a day. After approach of effect (usually in 10-14 days) the drug dose is gradually reduced to 1-2 tablets a day. The course of treatment makes 3-4 weeks, but in some cases according to indications drug is accepted it is long in a maintenance dose - 1 tablet a day.

Features of use:

Safety and efficiency of use of Raunatinum for children are not established. Adequate and controlled researches of influence of drug on women in the period of a lactation were not conducted.
Patients who constantly use drug should avoid occupations potentially dangerous types of activity which require special attention and speed mental and motor reactions.

Side effects:

Raunatinum at correctly picked up dose usually does not cause side effects, but swelling of a mucous membrane of a nose, perspiration, the general weakness, cardialgias, bradycardia, pains in heart, a depression, decrease in a libido is in some cases observed. By-effects are eliminated at reduction of a dose or after small (1-3 days) a break in its reception.

Interaction with other medicines:

Raunatinum can be applied at the same time or consistently with other anti-hypertensive drugs (ganglioblokator, Hydrochlorthiazidum, gidralaziny and др).

With care appoint together with quinidine, guanetidiny, cardiac glycosides, beta adrenoblockers (danger of strengthening of expressiveness negative hrono-and dromotropic action).

Raunatinum is capable to strengthen effect of alcohol and barbiturates on the central nervous system.

Contraindications:

Raunatinum is contraindicated at hypersensitivity to components of drug, arterial hypotension, depression, insufficiency of coronary circulation, organic lesions of a myocardium, aortal defects, a peptic ulcer of a stomach and a duodenum, a nephrosclerosis, in the last trimester of pregnancy, age up to 18 years.

Overdose:

There are no data.

Storage conditions:

In the dry place at a temperature not above 25 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Tablets, coated on 0,002 g. On 10 tablets in a blister strip packaging from a film of polyvinyl chloride and aluminum foil; on 50 tablets in polymeric banks. Each can or 5 blister strip packagings together with the application instruction are placed in a pack from a cardboard.

It is allowed to place 100 blister strip packagings in boxes from a cardboard or packages from a film polyethylene with the appendix of application instructions in the quantity equal to the number of packagings.