Immunoglobulin of the person antismallpox

General characteristics. Structure:

Active ingredient: 1,5 ml of antigens to ortopoksivirusa in a caption not less than 1:4000.

Pharmacological properties:

Pharmacodynamics. An effective agent of drug are the antibodies which are contained in immunoglobulin and having specific activity to ortopoksvirusa.

Prevention and treatment of complications of vaccinal process at imparted against natural smallpox; treatment and prevention of natural smallpox.

Indications to use:

— prevention and treatment of postvaccinal complications at children and adults on introduction of a vaccine smallpox live: generalization of vaccinal process, postvaccinal encephalitis and other complications;

— emergency prevention and treatment of natural smallpox.

Route of administration and doses:

Immunoglobulin is entered by in oil. For prevention of postvaccinal complications the drug is administered to initially vaccinated children once in a dose of 1.5 ml, adult - 3 ml just before vaccination.

For the emergency prevention of natural smallpox the drug is administered once in a dose of 3 ml.

For treatment of postvaccinal complications, and also for treatment of natural smallpox immunoglobulin enter in a dose 0.5-1 ml on body weight kg depending on weight of a clinical course of a disease. This dose can be entered into 1 reception or is divided into several injections in days. Duration of a course of treatment is defined by the attending physician.

It is forbidden to administer the drug in/in! Before an injection the ampoule with drug is maintained during 2 h at the room temperature. Opening of ampoules and the procedure of introduction are carried out at strict observance of rules of an asepsis and antiseptics. In order to avoid foaming drug is gathered in the syringe a needle with a wide gleam.

Drug in the opened ampoule is not subject to storage. Drug in ampoules with the broken integrity or marking is not suitable for use, at change of physical properties (discoloration, solution opacification, existence of not breaking flakes), at the expired period of validity, at disturbance of the mode of storage.

Administration of immunoglobulin is registered in the established registration forms with the indication of number of a series, date of production, a period of validity, manufacturer, Date of Introduction and the nature of reaction to administration of drug.

Features of use:

In day of administration of immunoglobulin and during the next 8 days purpose of antihistaminic drugs is recommended.

Side effects:

Side effects of immunoglobulin, as a rule, are absent.

In rare instances local reactions in the form of a hyperemia and temperature increase to 37,5 °C within the first 2 days after introduction can develop. At individuals with the changed reactivity могуг to develop allergic reactions of various type, and in exclusively exceptional cases - an acute anaphylaxis. In this regard, the persons who received drug have to be under medical observation within 30 min.

Venues of inoculations have to be provided with means of antishock therapy.

Interaction with other medicines:

Immunoglobulin antismallpox can be applied with a vaccine smallpox to prevention of postvaccinal complications.

Interactions with other medicines are not established.

Contraindications:

— heavy allergic reactions to introduction of blood preparations of the person in the anamnesis;

— allergic diseases;

— existence in the anamnesis clinically expressed allergic reactions.

Storage conditions:

Drug is stored and transported according to the joint venture. 3.3.2.1248-03 at a temperature from 2 °C to 8 °C in the place, unavailable to children. Freezing is not allowed. A drug period of validity - 2 years. Drug is not subject to expired use.

Issue conditions:

According to the recipe

Packaging:

1 dose - ampoules (10) - packs cardboard.
2 doses - ampoules (10) - packs cardboard.